Publications by authors named "Yaodan Liang"
Objective: The exact mechanism and target molecules of liver fibrosis have remained largely elusive. Here, we investigated the role of long noncoding RNA Gm9866(lncRNA-Gm9866) on liver fibrosis.
Methods: The transcription of lncRNA-Gm9866 in activated cells and mouse fibrotic livers was determined by quantitative polymerase chain reaction (qRT-PCR).
This study aimed to develop and validate an electronic frailty index (eFI) based on routine electronic health records (EHR) for older adult inpatients and to analyze the correlations between frailty and hospitalized events and costs. We created an eFI from routine EHR and validated the effectiveness by the consistency of the comprehensive geriatric assessment-frailty index (CGA-FI) with an independent prospective cohort. Then, we analyzed the correlations between frailty and hospitalized events and costs by regressions.
View Article and Find Full Text PDFPerformance of Prognostic Risk Scores in Elderly Chinese Patients with Heart Failure.
Clin Interv Aging
October 2021
Article Synopsis
- Elderly heart failure (HF) patients experience different characteristics and worse outcomes than younger patients, prompting a study to validate the Seattle Heart Failure Model (SHFM) and the MAGGIC score specifically for this demographic.
- A retrospective analysis of 675 older HF patients (aged 70+) showed that the SHFM had better predictive accuracy and calibration for 1-year mortality compared to the MAGGIC score, with lower predicted mortality rates and higher c-statistics.
- The study concluded that the SHFM is more reliable than the MAGGIC score in forecasting 1-year mortality risks for elderly Chinese HF patients, highlighting its effectiveness in assessing patient prognosis.
Background: The prognosis of patients with idiopathic dilated cardiomyopathy (DCM) has improved remarkably in recent decades with guideline-directed medical therapy. Left ventricular (LV) reverse remodeling (LVRR) is one of the major therapeutic goals. Whether myocardial fibrosis or inflammation would reverse associated with LVRR remains unknown.
View Article and Find Full Text PDFPrognostic value of left ventricular remodelling index in idiopathic dilated cardiomyopathy.
Eur Heart J Cardiovasc Imaging
September 2021
Aims: To evaluate the prognostic value of left ventricular (LV) remodelling index (RI) in idiopathic dilated cardiomyopathy (DCM) patients.
Methods And Results: We prospectively enrolled 412 idiopathic DCM patients and 130 age- and sex-matched healthy volunteers who underwent cardiovascular magnetic resonance imaging between September 2013 and March 2018. RI was defined as the cubic root of the LV end-diastolic volume divided by the mean LV wall thickness on basal short-axis slice.
Background: We aimed to assess the utility of the combination of the mini-mental state examination (MMSE) + clock drawing test (CDT) and the Fried phenotype for predicting non-elective hospital readmission or death within 6 months in elderly inpatients with cardiovascular disease (CVD).
Methods: A single-center prospective cohort was conducted from September 2018 to February 2019. Inpatients ≥65 years old were recruited.
The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty. A total of 508 elderly patients with cardiovascular disease (mean age 75.
View Article and Find Full Text PDFArticle Synopsis
- A study surveyed frailty prevalence among elderly inpatients across different hospital wards and compared the effectiveness of five frailty measurement tools in identifying frailty.
- The prevalence of frailty varied significantly, with higher rates found in non-surgical wards, and the Clinical Frailty Scale (CFS) and Frailty Index (FI) demonstrated strong sensitivity and specificity as screening tools.
- Risk factors for frailty included older age, lower educational level, faster heart rate, lower albumin levels, higher D-dimer levels, five or more comorbidities, and taking five or more medications.
Background: Peripartum cardiomyopathy (PPCM) is rare and potentially life-threatening; its etiology remains unclear. Imaging characteristics on cardiovascular magnetic resonance (CMR) and their prognostic significance have rarely been studied. We sought to determine CMR's prognostic value in PPCM by using T1 and T2 mapping techniques.
View Article and Find Full Text PDFAims: In addition to giving optimal medical and device therapy, promoting self-care of chronic heart failure (CHF) patients also plays an important role in comprehensive disease management for better outcomes. The study was aimed to investigate whether short message service (SMS) would help to improve death or readmission-free survival and self-care behaviour in CHF patients.
Methods And Results: This was a randomized controlled trial.
Background: Caregiving burden and depression in family caregivers have been investigated, but little is known about how they affect paid caregivers. The aim of this study was to investigate caregiving burden and depression in paid caregivers of hospitalized patients.
Methods: A cross-sectional survey study was conducted in a tertiary referral hospital (Chengdu, China) that enrolled 108 paid caregivers who worked in the inpatient department.