Publications by authors named "Yao-zhen Chen"
Mac1+/Gr1+ cells contribute to transfusion-related acute lung injury.
Transfus Apher Sci
December 2013
Transfusion-related acute lung injury (TRALI) is a serious complication associated with blood transfusion and can cause transfusion associated fatalities. Both antibody dependent and non-dependent mechanisms are involved in TRALI, as proposed over the past years. Nonetheless, many details of the immune cells involved in TRALI, particularly the Mac1(+)/Gr1(+) cells from donors, are not fully understood yet.
View Article and Find Full Text PDFObjectives: The prevalence of infectious diseases is increasing in developing countries, and this may threaten the biological safety of donated blood. This study analyzed trends in the prevalence of transfusion-transmissible infectious pathogens among Chinese, first-time, voluntary blood donors from 1999 to 2009 to evaluate the potential for disease transmission.
Methods: From 1999 to 2009, all first-time donors at the Xi'an Blood Service (XBS) were screened for hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis infections using enzyme-linked immunosorbent assays (ELISA); results were confirmed using alternative commercial kits.
HCV is prevailed in the world as well as in China. Blood transfusion is one of the most common transmission pathways of this pathogen. Although data of HCV infection character were reported during the past years, anti-HCV reactive profile of China donors was not fully clear yet.
View Article and Find Full Text PDFArticle Synopsis
- Thousands have died from HCV due to lack of vaccines and effective therapies, highlighting the need for new treatments.
- Cytotoxic T lymphocytes are key in the immune response against HCV, and combining T helper epitopes from tetanus toxin with HCV core protein may enhance vaccine development efforts.
- Research showed that modified plasmids increased antibody production and immune response in mice, suggesting a promising strategy for creating HCV vaccines.
Hepatitis B virus (HBV) is prevalent in China and screening of blood donors is mandatory. Up to now, ELISA has been universally used by the China blood bank. However, this strategy has sometimes failed due to the high frequency of nucleoside acid mutations.
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