Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer.

The function of the p53 protein is impaired by the overexpression of its negative regulator murine double minute 2 protein (MDM2) and homologous protein MDMX. Disruption of the p53-MDM2/MDMX interaction to restore the transcriptional function of p53 is considered a promising strategy for cancer therapy. To design dual MDM2/MDMX inhibitors, the binding modes of MDM2 or MDMX with their inhibitors are elucidated.

Mathematical modelling of sewage sludge incineration in a bubbling fluidised bed with special consideration for thermally-thick fuel particles.

Fluidised bed combustor (FBC) is one of the key technologies for sewage sludge incineration. In this paper, a mathematical model is developed for the simulation of a large-scale sewage sludge incineration plant. The model assumes the bed consisting of a fast-gas phase, an emulsion phase and a fuel particle phase with specific consideration for thermally-thick fuel particles.

Mathematical modelling of particle mixing effect on the combustion of municipal solid wastes in a packed-bed furnace.

Packed bed combustion is still the most common way to burn municipal solid wastes. In this paper, a dispersion model for particle mixing, mainly caused by the movement of the grate in a moving-burning bed, has been proposed and transport equations for the continuity, momentum, species, and energy conservation are described. Particle-mixing coefficients obtained from model tests range from 2.

Ignition and burning rates of segregated waste combustion in packed beds.

Recent developments in national recycling and re-use programmes for municipal waste have led to segregation of an increasing proportion of waste to enhance material recovery. Several of the segregated streams contain materials that can not viably be re-used or recycled but can be used for energy recovery. In this study, the combustion of cardboard and waste wood was investigated in a small-scale packed bed reactor in order to provide fundamental data for the design/operation of moving bed furnaces.

Converting moving-grate incineration from combustion to gasification - numerical simulation of the burning characteristics.

Waste incineration is a politically sensitive issue in the UK. The major current technology is based on direct combustion of wastes in a moving-grate furnace. However, general public opinion prefers non-direct burning technologies.