Publications by authors named "Yao-Wu Yang"

Article Synopsis
  • - Non-selective β-blocker propranolol is FDA-approved as the primary treatment for infantile hemangioma (IH) due to its significant effectiveness.
  • - Timolol maleate has emerged as a popular alternative to propranolol, aiming to reduce systemic side effects, but there is still debate on various aspects of its use, including indications and dosage.
  • - A consensus developed by Chinese experts aims to standardize topical timolol treatment for IH, helping to minimize complications and improve clinical practices based on current evidence.
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Infantile hemangioma (IH) is one of the most common benign vascular tumors in children. A variety of treatment methods have been documented for the management of IH over the past years, including pharmacotherapy via oral administration or injection of corticosteroids, vincristine, alpha interferon and bleomycin; laser therapy, radionuclide therapy, cryotherapy and excisional surgery. The therapeutic efficacy of each treatment modality is variable, while adverse effects or complications are common and sometimes serious.

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Arteriovenous malformations (AVMs) are congenital vascular malformations (CVMs) resulting from birth defects of the vasculature. It is rarely seen, only accounting for 1.5% of all vascular anomalies, and 50% of the lesions are located in the oral and maxillofacial region.

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Venous malformation is one of the most common benign vascular lesions, with approximately 40% of cases appearing in the head and neck. They can affect a patient's appearance and functionality and even cause life-threatening bleeding or respiratory tract obstruction. The current methods of treatment include surgery, laser therapy, sclerotherapy, or a combined.

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Inferior alveolar nerve (IAN) injury is a concern in mandible distraction osteogenesis (DO). We have previously demonstrated that repeated local injections of human nerve growth factor beta (NGF-beta) have significantly enhanced the histologic recovery of the IAN in a rabbit model of DO. This study was to further test the effect of a single injection of human NGF-beta delivered via a collagen/nanohydroxyapatite/kappa-carrageenan gel to the recovery of the IAN in DO.

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Objective: Fabricate series of the controllable degradation coral-hydroxyapatite.

Methods: The natural coral undergo a chemical reaction with (NH4)2 HPO4 at high temperature and pressure for different time-lengths. After getting the products, the components and the special structures were analyzed.

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Hsp70 potentiates specific immune responses to some antigenic peptides fused to it. A recombinant hsp70 protein expression vector in methylotrophic yeast, Pichia pastoris, was developed that fused the major antigenic segment of Japanese encephalitis virus (JEV) E protein to the amino terminus of Mycobacterium tuberculosis hsp70. The C-terminal peptide binding domain of hsp70 stimulated Th1-polarizing cytokines, CC chemokines and an adjuvant effect.

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Article Synopsis
  • A recombinant vector combining the JEV E protein with M. tuberculosis hsp70 was developed in yeast for easier protein expression and purification, avoiding common issues found in bacterial systems.
  • Immunization studies in mice showed that the E-hsp70 fusion protein generated a stronger immune response compared to the individual components, as measured by cytokine production and antibody levels.
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Article Synopsis
  • - The study aimed to analyze the presence of SARS-CoV RNA in the blood and excretion of patients who had recovered from SARS for better understanding and treatment of the virus.
  • - Researchers tested 276 samples (plasma, urine, feces, sputum) from 23 convalescent patients, discovering that about 39% tested positive for SARS-CoV RNA, primarily in feces and sputum, but none were found in plasma or urine.
  • - The findings suggest that some recovered patients still excrete SARS-CoV RNA, highlighting the need for careful handling of excretions to prevent possible re-transmission of the virus.
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Purpose: To observe the osteogenesis of sodium calcium phosphate/beta-tricalcium phosphate scaffold loaded with marrow stromal cells in a nude mice subcutaneous model.

Methods: To transform the sintered bovine cancellous bone into NaCaPO(4)/beta-TCP biphasic calcium phosphate ceramic by physical and chemical methods. Bone marrow stromal cells (BMSCs) were obtained by harvesting the cancellous bone from the iliac crest of a rabbit.

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Objective: By the histologic observation of samples, understanding the osteoconductive histologic behaviour and resorbable mechanism of beta-tricalcium phosphate (beta-TCP).

Methods: Porous block beta-TCP samples were implanted into calvarial surface. Tissue slices dyed with methods of HE and Masson's were observed by microscope and compared with hydroxyapatite(HA).

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Objective: To transform the sintered ostrich cancellous bone(ostrich true bone ceramic, OTBC) to multiphasic calcium phosphate ceramic and study its components and characterization.

Methods: The OTBC blocks were soaked in different concentration of sodium pyrophosphate (Na(4)P(2)O(7).H(2)O,NP) solution and heated to 1100 degrees C to transform its constitution from HAP into multiphasic calcium phosphate ceramics.

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