Publications by authors named "Yao-Sheng Li"
The precise and targeted delivery of therapeutic agents to the lesion sites remains a major challenge in treating brain diseases represented by ischemic stroke. Herein, we modified liposomes with mesenchymal stem cells (MSC) membrane to construct biomimetic liposomes, termed MSCsome. MSCsome (115.
View Article and Find Full Text PDFMesenchymal stem cell (MSC)-based therapies are flourishing. MSCs could be used as potential therapeutic agents for regenerative medicine due to their own repair function. Meanwhile, the natural predisposition toward inflammation or injury sites makes them promising carriers for targeted drug delivery.
View Article and Find Full Text PDFArticle Synopsis
- - Mesenchymal stem cells (MSCs) are considered effective for drug delivery but face challenges with drug capacity and safety; this study introduces MSC membrane-coated mesoporous silica nanoparticles (MSN@M) as a solution.
- - The integration of MSC membranes onto mesoporous silica nanoparticles improved stealth and reduced clearance by the immune system, allowing for better targeting and drug retention in cancerous tissues.
- - When tested in mice with tumors, MSN@M demonstrated significantly enhanced drug loading, sustained release of doxorubicin (DOX), and effectively inhibited tumor growth while minimizing side effects, suggesting it could be a promising alternative for antitumor therapies.
Understanding how systems with many semi-autonomous parts reach a desired target is a key question in biology (e.g., larvae seeking food), engineering (e.
View Article and Find Full Text PDFManipulation of the magnetoresistance effect in a double-helix DNA.
J Phys Condens Matter
November 2018
Magnetoresistance (R ) of a double-stranded (G:C) DNA sandwiched between ferromagnetic electrodes has been studied using the transfer matrix method of the tight-binding model. A R magnitude up to 72.5% for DNA in its natural structure is observed when the spin-orbit coupling with the helix spring geometry and a possible dephasing effect are taken into account.
View Article and Find Full Text PDF[Reverse second dorsal metatarsal artery island flap for repairing the soft tissue defect at toes].
Zhonghua Zheng Xing Wai Ke Za Zhi
November 2009
Objective: To report the application of reverse second dorsal metatarsal artery island flap for From May 2005 to September 2008, 5 cases with soft tissue repairing the soft tissue defect at toes.
Methods: defects at toes were treated with reverse second dorsal metatarsal artery island flaps. The flaps size ranged from 2 cm x 3 cm to 5 cm x 6 cm.
[Repair of the soft tissue defect of the fifth finger with a reversed ulnar fasciocutaneous flap from the fifth metacarpal side].
Zhonghua Zheng Xing Wai Ke Za Zhi
January 2005
Objective: To introduce a method by reversed ulnar fasciocutaneous flap incised form the ulnar side of the fifth metacarpal area for repairing the soft tissue defect of the fifth finger.
Methods: From May 2001 to September 2001, ten patients with the soft tissue defects of the thenar side, dorsal side or ulnar side of the fifth finger were treated with the reversed ulnar fasciocutaneous flap incised from the fifth metacarpal area. The axial line of the flap was the line from ulnar side of the head of the fifth metacarpal bone to the pisiform level.