Publications by authors named "Yao-Ling Xiong"
Article Synopsis
- Curcin can inhibit tumor cell growth and promote cell death but lacks selectivity between tumor and normal cells.
- To enhance curcin's targeting ability, it was fused with a transferrin receptor binding peptide (TfRBP9) and a recombinant vector was created to express this fusion protein in E. coli.
- The curcin-TfRBP9 fusion showed greater effectiveness in inhibiting the proliferation of HepG2 liver cancer cells, especially those with high transferrin receptor expression, while being less harmful to normal liver cells.
This paper is to report the study of the pharmacokinetics of a fusion protein TAT-haFGF(14-154) for human acidic fibroblast growth factor and transcriptional activator protein in rat plasma, and the investigation of their penetration across blood-brain barrier in mice and rats, in order to provide a basis for clinical development and treatment of Alzheimer's disease. Enzyme-linked immunosorbent assay (ELISA) was used to determine concentration of TAT-haFGF(14-154) in rat plasma and in mouse brain homogenate; and immunohistochemistry was used to analyze the distribution in brain. The concentration-time curve fitted two-compartment open model which was linear kinetics elimination after a single intravenous injection of TAT-haFGF(14-154) in rat at the dose of 300 microg x kg(-1).
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