Publications by authors named "Yao-Lin Yang"
Background: Heart failure (HF), which is caused by cardiac overload and injury, is linked to significant mortality. Writers of RNA modification (WRMs) play a crucial role in the regulation of epigenetic processes involved in immune response and cardiovascular disease. However, the potential roles of these writers in the immunological milieu of HF remain unknown.
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- Dapagliflozin shows cardioprotective and nephroprotective benefits, but its overall impact on all-cause death rates is not fully understood.
- A meta-analysis of five phase III randomized controlled trials revealed an 11.2% reduction in all-cause death risk among dapagliflozin users compared to those on placebo.
- While dapagliflozin did not significantly raise the risk of urinary tract infections, bone fractures, or amputations, it was associated with a higher risk of genital infections and a reduction in acute kidney injury.
Article Synopsis
- The study aimed to compare the effectiveness of SGLT2 inhibitors for treating patients with established heart failure by reviewing existing clinical trials.
- A systematic review of five trials showed no significant differences in major outcomes like cardiovascular death or hospitalization for heart failure among dapagliflozin, empagliflozin, and sotagliflozin.
- While overall efficacy appeared similar, there were hints that sotagliflozin might be linked to the lowest risk for combined negative outcomes.
Article Synopsis
- A systematic review and meta-analysis examined the impact of sodium-glucose cotransporter-2 (SGLT2) inhibitors on cardiorenal outcomes in patients with chronic kidney disease (CKD) using data from randomized controlled trials on PubMed and Embase.
- The analysis included three trials and indicated that SGLT2 inhibitors collectively reduced the cardiorenal outcome by 27.5%, showing effectiveness in both diabetic and non-diabetic patients.
- While no significant differences in outcomes were found between the three specific SGLT2 inhibitors tested, dapagliflozin appeared to have the lowest risk associated with adverse cardiorenal outcomes.
Since its outbreak in China, the Coronavirus disease 2019 (COVID-19) pandemic has caused worldwide disaster. Globally, there have been 71,581,532 confirmed cases of COVID-19, including 1,618,374 deaths, reported to World Health Organization (data retrieved on December 16, 2020). Currently, no treatment modalities for COVID-19 (e.
View Article and Find Full Text PDF[Effects of Modified Ruji Recipe in Preventing Relapse and Metastasis of Breast Cancer Patients with Negative Hormone Receptor].
Zhongguo Zhong Xi Yi Jie He Za Zhi
February 2017
Objective To observe the effect of Ruji Recipe (RR) (treated by syndrome typing) in preventing the relapse and metastasis of invasive ductal breast cancer patients with negative hormone receptor (HR) after surgery and chemotherapy. Methods Using a prospective, cohort method, 136 pa- tients with stage I - III C HR negative invasive ductal breast cancer were equally assigned to the treat- ment group (treated by RR in syndrome typing way) and the control group (routine follow-ups). Disease free survival (DFS) , overall survival (OS) , relapse and metastasis were observed in the two groups.
View Article and Find Full Text PDF[Effect of ruji recipe on the post-surgical survival of female breast cancer patients].
Zhongguo Zhong Xi Yi Jie He Za Zhi
October 2013
Objective: To observe the effect of Ruji Recipe (RR) in preventing disease recurrence/metastasis and improving quality of life (QOL) for female breast cancer patients after operation.
Methods: Totally 102 female patients with stage I - III breast cancer were retrospectively analyzed. They were assigned to the treatment group (54 cases) and the control group (48 cases) according to whether they would rather accept RR therapy.
Nitric oxide scavenger carboxy-PTIO reduces infarct volume following permanent focal ischemia.
Acta Anaesthesiol Taiwan
September 2006
Background: Nitric oxide (NO) has been shown to play a dual role as a neuroprotectant and a neurotoxin in cerebral ischemia. Free radical scavengers protect brain tissue from ischemic injury. Consequently, we examined the neuroprotective action of NO scavenger, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), in cerebral ischemia induced by permanent middle cerebral artery occlusion (MCAO) in rats and mice.
View Article and Find Full Text PDFBackground: The major purpose of this study is to evaluate and compare the clinical characteristics of sevoflurane-nitrous oxide and propofol-nitrous oxide anesthesias conveyed by laryngeal mask airway (LMA) in patients for gynecological procedures.
Methods: Eighty female patients were randomly assigned to one of the two groups: Group I, inhalational induction at vital capacity with 8% sevoflurane and 67% nitrous oxide in oxygen; Group II, induction with intravenous propofol at 2 mg/kg followed by intravenous infusion at 6 mg/kg/hr. The LMA was inserted after loss of response to jaw thrusting.