Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer.

To develop novel GLS1 inhibitors as effective therapeutic agents for triple-negative breast cancer (TNBC), 25 derivatives were synthesized from the natural inhibitor withangulatin A (IC = 18.2 μM). Bioassay optimization identified a novel and selective GLS1 inhibitor 7 (IC = 1.

Cytotoxic Germacranolides from the Whole Plant of .

Eight new germacranolides, minusolides A-H (-), along with two known analogues, and , were isolated from the whole plant of . Their structures were elucidated by spectroscopic analysis. Compounds and , and and are two pairs of rare epimers with opposite configurations at C-2 of the 2-methylbutyryloxy group.

New obovatol trimeric neolignans with NO inhibitory activity from the leaves of Magnolia officinalis var. biloba.

Six new obovatol trimeric neolignans, houpulignans A-F (1-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined on the basis of the interpretation of HRESIMS, NMR data, and electronic circular dichroism (ECD) calculations.