Publications by authors named "Yao-Hai Wen"
Research (Wash D C)
April 2023
Article Synopsis
- Disturbance in the cholinergic system is linked to neurological diseases that cause dyskinesia-like behaviors, but the exact mechanisms are unclear.
- Research shows that levels of cyclin-dependent kinase 5 (CDK5) are lower in cholinergic neurons in the midbrain and in the blood of Parkinson's disease patients, correlating with motor symptoms.
- CDK5's reduced activity leads to increased hyperexcitability in cholinergic neurons and contributes to abnormal motor functions, with its restoration showing promise in reducing dyskinesia-like behaviors in mice.
