METTL3-mediated mA modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.

N6-methyladenosine (mA), the most prevalent internal modification in mRNA, is related to the pathogenesis of osteoporosis (OP). Although methyltransferase Like-3 (METTL3), an mA transferase, has been shown to mitigate OP progression, the mechanisms of METTL3-mediated mA modification in osteoblast function remain unclear. Here, fluid shear stress (FSS) induced osteoblast proliferation and differentiation, resulting in elevated levels of METTL3 expression and mA modification.

Screening and identification of potential hub genes and immune cell infiltration in the synovial tissue of rheumatoid arthritis by bioinformatic approach.

Background: Rheumatoid arthritis (RA) is an autoimmune disease that affects individuals of all ages. The basic pathological manifestations are synovial inflammation, pannus formation, and erosion of articular cartilage, bone destruction will eventually lead to joint deformities and loss of function. However, the specific molecular mechanisms of synovitis tissue in RA are still unclear.

Application of Triggered EMG in the Intraoperative Neurophysiological Monitoring of Posterior Percutaneous Endoscopic Cervical Discectomy.

Objective: To describe the rationale and application of triggered EMG (T-EMG) in intraoperative neurophysiological monitoring, and to explore the efficacy and safety of posterior percutaneous endoscopic cervical discectomy (PPECD) in the treatment of cervical spondylotic radiculopathy (CSR) under multimodal intraoperative neurophysiological monitoring (IOM).

Methods: This study was a retrospective cohort control study. The clinical data of 74 patients with single-segment CSR from June 2015 to August 2018 were analyzed retrospectively, of whom 35 underwent IOM-assisted PPECD with triggered EMG (T-EMG group), while 39 were subjected to IOM-assisted PPECD alone (IOM group).

Percutaneous Transforaminal Endoscopic Discectomy and Fenestration Discectomy to Treat Posterior Ring Apophyseal Fractures: A Retrospective Cohort Study.

Objective: To compare the efficacy and safety of percutaneous transforaminal endoscopic discectomy (PTED) and fenestration discectomy (FD) for posterior ring apophyseal fractures (PRAF).

Methods: This study was a retrospective cohort control study. A total of 96 patients with lumbar PRAF who underwent surgical treatment at the Henan Provincial People's Hospital of Henan University from September 2013 to December 2017 were retrospectively examined, of which 51 were treated by PTED and 45 by FD.

[Spatiotemporal variation of vegetation net primary productivity and its driving factors from 2000 to 2015 in Qinling-Daba Mountains, China.].

We analyzed spatiotemporal changes in vegetation net primary productivity (NPP) in the Qinling-Daba Mountains based on MOD17A3 data and driving factor data from 2000 to 2015. We used trend analysis, Hurst index, and correlation analysis to examine the effects of climate change, soil type, topographic factors, vegetation type, and human activities on NPP. With respect to spatial variation, NPP was the highest in southwestern area and lowest in the northeast.

[Evaluation of the forest ecosystem service values in Qinling, China].

Landsat TM images of Mt. Qinling in 1984, 2000, 2005, and 2014 were used to extract land use and land cover type by a supervised classification method in ERDAS software. Equivalent factor of ecosystem service value per unit area was revised regionally in temporal and spatial dimensions, and then was modified pixel by pixel using the vegetation coverage.

Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina.

Ethnopharmacological Relevance: Hemerocallis citrina, a traditional herbal medicine, has been used for the improvement of emotions in Eastern-Asia countries.

Aim Of The Study: Herein, we explored the antidepressant-like effect and its monoaminergic mechanism of the ethanol extracts from Hemerocallis citrina (HCE).

Materials And Methods: Effect of HCE (90, 180 and 360 mg/kg, p.

[Forensic pathological analysis on 23 cases of fatal pulmonary thromboembolism].

Objective: To analyze the forensic pathological characteristics of sudden death caused by pulmonary thromboembolism and the chronological transformation of thrombus and explore the assessment method of the causal relationship between previous trauma and the following fatal PTE episode.

Methods: All the 23 cases reviewed here were collected from our institute files from the year of 1998 to 2008.

Results: Trauma, surgery and braking etc.