Optimizing Interfacial Charge Dynamics and Quantum Effects in Heterodimensional Superlattices for Efficient Hydrogen Production.

Superlattice materials have emerged as promising candidates for water electrocatalysis due to their tunable crystal structures, electronic properties, and potential for interface engineering. However, the catalytic activity of transition metal-based superlattice materials for the hydrogen evolution reaction (HER) is often constrained by their intrinsic electronic band structures, which can limit charge carrier mobility and active site availability. Herein, a highly efficient electrocatalyst based on a VS-VS heterodimensional (2D-1D) superlattice with sulfur vacancies is designed addressing the limitations posed by the intrinsic electronic structure.

Association between obesity measurement indexes and symptomatic knee osteoarthritis among the Chinese population: analysis from a nationwide longitudinal study.

Background: The current literature lacks robust clinical data and evidence delineating the relationship between obesity measurement indexes and knee osteoarthritis (KOA). Consequently, this investigation seeks to elucidate the potential link between obesity measurement indexes and KOA among Chinese adults in a nationally representative study.

Methods: Firstly, this research performed an observational study in the China Health and Retirement Longitudinal Study (CHARLS).

Enantioselective construction of C-B axially chiral alkenylborons by nickel-catalyzed radical relayed reductive coupling.

The catalytic asymmetric synthesis of axially chiral alkenes remains a daunting challenge due to the lower rotational barrier, especially for longer stereogenic axis (e.g. C-B axis).

Hyperbranched Thermosensitive Polymer-AuNP Composite Probe for Temperature Colorimetric Detection.

Temperature detection is particularly important in the medical and scientific fields. Although there are various temperature detection methods, most of them focus on broad temperature detection, and basic research in specific fields, especially the detection of subtle temperature changes (32-34 °C) during wound infection, is still insufficient. For this purpose, a novel colorimetric temperature sensing probe is designed in this paper, which can quickly and intuitively respond to small temperature changes within a specific range through color changes.

Releasing a sugar brake generates sweeter tomato without yield penalty.

In tomato, sugar content is highly correlated with consumer preferences, with most consumers preferring sweeter fruit. However, the sugar content of commercial varieties is generally low, as it is inversely correlated with fruit size, and growers prioritize yield over flavour quality. Here we identified two genes, tomato (Solanum lycopersicum) calcium-dependent protein kinase 27 (SlCDPK27; also known as SlCPK27) and its paralogue SlCDPK26, that control fruit sugar content.

Overview and trend analysis of global hot spring research based on bibliometrics and knowledge graph visualization.

Background: The scope of hot spring research is continuously growing, with the application of hot spring medicine emerging as a significant trend. However, there is a lack of bibliometric analyses that summarize the current state and trends of the application of hot spring medicine.

Objectives: Using bibliometric analysis, this study aims to visualize and analyze the global landscape and emerging trends in hot spring research, focusing on the hotspots and future directions of hot spring medicine application.

Palladium-catalyzed C-H bond activation and decarboxylation for the assembly of indolo[1,2-]phenanthridine.

A direct and convenient strategy for the assembly of indolo[1,2-]phenanthridine a Pd-catalyzed tandem cyclization reaction is presented. The current strategy delivers a range of indolo[1,2-]phenanthridine derivatives by utilizing readily available 1-(2-iodophenyl)-1-indole and commercially available -bromobenzoic acids as the starting materials. The reaction features the formation of two C-C bonds through Pd-catalyzed C-H bond activation and decarboxylation.

LAP2α orchestrates alternative lengthening of telomeres suppression through telomeric heterochromatin regulation with HDAC1: unveiling a potential therapeutic target.

In response to the challenge of telomere attrition during DNA replication, cancer cells predominantly employ telomerase or, in 10-15% of cases, the alternative lengthening of telomeres (ALT). The intricate details of ALT, however, remain elusive. In this study, we unveil that the knockdown of lamina-associated polypeptide 2 alpha (LAP2α) in ALT cells results in telomere dysfunction, triggering a notable increase in ALT-associated hallmarks, including high frequencies of PML bodies (APBs), C-rich extrachromosomal circles (C-circles), and telomere sister chromatid exchange (T-SCE).

Benign Saturation of Ideal Ballooning Instability in a High-Performance Stellarator.

To examine the robustness of the designed 5% β limit for high-performance operation in the W7-X stellarator, we undertake nonlinear magnetohydrodynamic (MHD) simulations of pressure-driven instabilities using the m3d-c1 code. Consistent with linear analyses, ideal ballooning instabilities occur as β exceeds 5% in the standard configuration. Nonetheless, the modes saturate nonlinearly at relatively low levels without triggering large-scale crashes, even though confinement degradation worsens as β increases.

Recombinase-aided amplification assay for rapid detection of imipenem-resistant and rifampin-resistant .

The indiscriminate use of antibiotics has resulted in a growing resistance to drugs in . The identification of antibiotic resistance genes holds considerable clinical significance for prompt diagnosis. In this study, we established and optimized a Recombinase-Aided Amplification (RAA) assay to detect two genes associated with drug resistance, and , in 101 clinically collected isolates.

Discovery of ferroptosis-related genes in renal ischemia reperfusion and evaluate the potential impact on kidney transplantation.

Background: Renal ischemia reperfusion injury (IRI) is one of the pivotal event of acute kidney injury (AKI), and they are unavoidable in the process of kidney transplantation, which eventually leads to the loss of renal allograft. Ferroptosis is a newly identified programmed cell death. Recent studies have suggested that ferroptosis may participate in the pathophysiological process of renal IRI.

Curcumin and nanodelivery systems: New directions for targeted therapy and diagnosis of breast cancer.

As the global incidence of breast cancer continues to surge, the pursuit of novel, low-toxicity, and highly efficacious therapeutic strategies has emerged as a pivotal research focus. Curcumin (CUR), an active constituent of traditional Chinese medicine (TCM) renowned for its antimicrobial, anti-inflammatory, antioxidant, and antitumor properties, exhibits immense potential in breast cancer therapy. Nevertheless, CUR's poor water solubility, chemical instability, and unfavorable pharmacokinetics have impeded its clinical utilization.

Semantic redundancy-aware implicit neural compression for multidimensional biomedical image data.

The surge in advanced imaging techniques has generated vast biomedical image data with diverse dimensions in space, time and spectrum, posing big challenges to conventional compression techniques in image storage, transmission, and sharing. Here, we propose an intelligent image compression approach with the first-proved semantic redundancy of biomedical data in the implicit neural function domain. This Semantic redundancy based Implicit Neural Compression guided with Saliency map (SINCS) can notably improve the compression efficiency for arbitrary-dimensional image data in terms of compression ratio and fidelity.

Efficacy and safety of low-dose interleukin 2 in the treatment of moderate-to-severe bullous pemphigoid: A single center perspective-controlled trial.

Background: Regulatory T cells (Tregs) are reduced in the peripheral blood and skin lesions of patients with bullous pemphigoid (BP). Low-dose interleukin 2 (IL-2) therapy can stimulate Tregs specifically, suggesting potential for the treatment of BP.

Objective: To evaluate the response to low-dose IL-2 therapy in the treatment of moderate-to-severe BP.

PAFerroptosis Combined with Metabolic Disturbance of Mito by p52-ZER6 for Enhanced Cancer Immunotherapy induced by Nano-Bacilliform-Enzyme.

The confused gene expressions and molecular mechanisms for mitochondrial dysfunction of traditional nanoenzymes is a challenge for tumor therapy. Herein, a nano-bacilliform-enzyme obtains the ability to inhibit p52-ZER6 signal pathway, regulate the genes related to mitochondrial metabolism, and possess the GOx/CAT/POD-like property. NBE acquires catalytic activity from the electronic energy transition.