Motivations and strategies of voluntary service for urban home-based older adults provided by volunteers with nursing background: a qualitative study.

Background: With the acceleration of population aging, it becomes increasingly difficult to meet the complex needs of older adults living in communities. Although volunteering is an important resource in addressing the aging crisis, the lack of clear motivations and finely-tuned strategic guidance present obstacles. This study aims to understand the motivations and strategies involved in voluntary service for urban home-based older adults provided by volunteers with a nursing background.

Enhancement of Impact Resistance and Shock Wave Protection in Strain Rate-Reinforced Leather Composite.

This work develops the Leather/SSG composite with a laminated structure that consists of flexible leather and rate-dependent shear stiffening gel (SSG), which exhibits superior impact resistance and shock wave protection performance. The SSG is tightly bound to the leather fiber network through hydrogen bonding interactions between the interfaces. Owing to the phase change energy absorption effect of SSG and the synergizing impact force dispersion along the disordered fibers, the Leather/SSG can effectively alleviate the impact force (52%) and shows high energy absorption (0.

Photoinduced synthesis of functionalized spiro[2.3]hexane an additive-free approach.

A general green protocol for the synthesis of spiro[2.3]hexane avoiding the use of harmful and toxic reagents is described. Spirocyclic scaffolds can be constructed by using alkenes of low reactivity under visible-light irradiation only.

Nitrogen-Doped Ultrananocrystalline Diamond - Optoelectronic Biointerface for Wireless Neuronal Stimulation.

This study presents a semiconducting optoelectronic system for light-controlled non-genetic neuronal stimulation using visible light. The system architecture is entirely wireless, comprising a thin film of nitrogen-doped ultrananocrystalline diamond directly grown on a semiconducting silicon substrate. When immersed in a physiological medium and subjected to pulsed illumination in the visible (595 nm) or near-infrared wavelength (808 nm) range, charge accumulation at the device-medium interface induces a transient ionic displacement current capable of electrically stimulating neurons with high temporal resolution.

Structure Optimization of Natural Product Catalpol to Obtain Novel and Potent Analogs against Heart Failure.

Heart failure (HF) is a major global health threat, characterized by high morbidity and mortality. Targeting cardiac hypertrophy has been identified as a potential therapy for HF, with current treatments showing limited efficacy. Our research aims to address this limitation by exploring new structural classes of therapeutic agents.

Cutaneous pseudolymphoma: a case series of three patients.

Cutaneous pseudolymphoma is a type of reactive lymphoid hyperplasia that pathologically and/or clinically mimics cutaneous lymphoma. It has a variety of pathogenic factors. However, in many cases, no etiology can be identified.

Spatial integration of multi-omics single-cell data with SIMO.

Technical limitations in spatial and single-cell omics sequencing pose challenges for capturing and describing multimodal information at the spatial scale. To address this, we develop SIMO, a computational method designed for the Spatial Integration of Multi-Omics datasets through probabilistic alignment. Unlike previous tools, SIMO not only integrates spatial transcriptomics with single-cell RNA-seq but expands beyond, enabling integration across multiple single-cell modalities, such as chromatin accessibility and DNA methylation, which have not been co-profiled spatially before.

Understanding nursing students' first experience of patient death in clinical practice: A qualitative systematic review and meta-synthesis.

Background: Witnessing patient death for the first time poses significant challenges for nursing students. Understanding their experiences can inform improvements in educational and support strategies within nursing programs.

Aim: This qualitative systematic review aimed to examines nursing students' initial encounters with patient death, emphasizing their perceptions, emotional responses, and coping mechanisms.

Enhancement of structural and functional photoacoustic imaging based on a reference-inputted convolutional neural network.

Photoacoustic microscopy has demonstrated outstanding performance in high-resolution functional imaging. However, in the process of photoacoustic imaging, the photoacoustic signals will be polluted by inevitable background noise. Besides, the image quality is compromised due to the biosafety limitation of the laser.

Nanodiamond-mediated delivery of microRNA-7 for the neuroprotection of dopaminergic neurons.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates known as Lewy bodies. MicroRNA-7 (miR-7) targets the gene , which encodes α-synuclein, reducing its expression and alleviating neuronal damage in PD. Regulating the post-transcriptional levels of α-synuclein through miR-7 effectively inhibits its production.

Permeable, Stretchable, and Recyclable Cellulose Aerogel On-Skin Electronics for Dual-Modal Sensing and Personal Healthcare.

Flexible on-skin electronics present tremendous popularity in intelligent electronic skins (e-skins), healthcare monitoring, and human-machine interfaces. However, the reported e-skins can hardly provide high permeability, good stretchability, and large sensitivity and are limited in long-term stability and efficient recyclability when worn on the human body. Herein, inspired from the human skin, a permeable, stretchable, and recyclable cellulose aerogel-based electronic system is developed by sandwiching a screen-printed silver sensing layer between a biocompatible CNF/HPC/PVA (cellulose nanofiber/hydroxypropyl cellulose/poly(vinyl alcohol)) aerogel hypodermis layer and a permeable polyurethane layer as the epidermis layer.

CRISPR/Cas14a integrated with DNA walker based on magnetic self-assembly for human papillomavirus type 16 oncoprotein E7 ultrasensitive detection.

To enhance the biomarker diagnostics sensitivity and selectivity of human papillomavirus type 16 oncoprotein E7 (HPV16 E7) in serum, a label/enzyme-free electrochemical detection platform was developed. This platform featured a type of "Super-turn-off" nanobiosensor monitored through differential pulse voltammetry (DPV). It integrated the magnetic self-assembly property of the α-FeO/FeO@Au/Sub/BSA signal transport nano-medium with the high specificity of CRISPR/Cas14a and the amplification capability of the bipedal walker (DNA walker composed of two ssDNA strands), resulting in the enhanced specificity and anti-interference performance while remaining stable at 4 °C for over 30 days.

Interstitial telomeric sequences promote gross chromosomal rearrangement via multiple mechanisms.

Telomeric DNA sequences are difficult to replicate. Replication forks frequently pause or stall at telomeres, which can lead to telomere truncation and dysfunction. In addition to being at chromosome ends, telomere repeats are also present at internal locations within chromosomes, known as interstitial telomeric sequences (ITSs).

Cobalt-Doped Carbon Nitride for Efficient Removal of via Peroxymonosulfate Activation.

Heterogeneous persulfate activation is an advanced technology for treating harmful algae in drinking water sources, while it remains a significant hurdle in the efficient management of cyanobacterial blooms. In this study, super-dispersed cobalt-doped carbon nitride (2CoCN) was prepared to activate peroxymonosulfate (PMS) for simultaneous inhibition and microcystin (MC-LR) degradation. When the initial PMS and 2CoCN concentrations were 0.

Photo-induced transformation of α-diazocarbonyl compounds into mono-substituted alpha-halogen derivatives.

Herein, the hydrogen halogenation reaction of diazo compounds with three new halogenating agents under photoinduced conditions is reported. This method realized hydrofluorination, hydrochlorination, and hydrobromination (56 cases in total, with the highest preparative yield of 94%) without requiring heating, transition metal catalysts or photocatalysts and exhibits a broad substrate scope. Notably, gram-scale synthesis using a continuous flow reactor was performed.

Achieving Excess Hydrogen Output via Concurrent Electrochemical and Chemical Redox Reactions on P-Doped Co-Based Catalysts with Electron Manipulation and Kinetic Regulation.

Electrolytic hydrogen production is of great significance in energy conversion and sustainable development. Traditional electrolytic water splitting confronts high anode voltage with oxygen generation and the amount of hydrogen produced at cathode depends entirely on the quantity of electric charge input. Herein, excess hydrogen output can be achieved by constructing a spontaneous hydrazine oxidation reaction (HzOR) coupled hydrogen evolution reaction (HER) system.

Revisiting the role of the spindle assembly checkpoint in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae.

Multiple pathways are known to suppress the formation of gross chromosomal rearrangements (GCRs), which can cause human diseases including cancer. In contrast, much less is known about pathways that promote their formation. The spindle assembly checkpoint (SAC), which ensures the proper separation of chromosomes during mitosis, has been reported to promote GCR, possibly by delaying mitosis to allow GCR-inducing DNA repair to occur.

Novel Combination Therapy for Heart Failure: Trimebutine-Methoxsalen Identified through Synergistic Network Virtual Screening and Experimental Validation.

Combination therapy is increasingly favored by pharmaceutical companies and researchers as an effective way to quickly discover new drugs with excellent efficacy, especially in the treatment of complex diseases. Previously, we successfully developed a computational screening method to identify such combinations, although it fell short in elucidating their synergistic mechanisms. In this work, we have transitioned to a highest single agent (HSA) synergy model for network screening, which streamlines the discovery of promising combinations and facilitates the investigation of their synergistic effects.

The genetic landscape of neuro-related proteins in human plasma.

Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.

Discovery of novel BfmR inhibitors restoring carbapenem susceptibility against carbapenem-resistant by structure-based virtual screening and biological evaluation.

The emergence and spread of pose a severe threat to public health, highlighting the urgent need for the next generation of therapeutics due to its increasing resistance to existing antibiotics. BfmR, a response regulator modulating virulence and antimicrobial resistance, shows a promising potential as a novel antimicrobial target. Developing BfmR inhibitors may propel a new therapeutic direction for intractable infection of resistant strains.

Precise management and control around the landfill integrating artificial intelligence and groundwater pollution risks.

The Landfill plays an important role in urban development and waste disposal. However, landfill leachate may also bring more serious pollution and health risks to the surrounding groundwater environment. Compared with other areas, the area around the landfill needs more precise management.

Complete genome sequence of strain XH2169.

Here, we report the complete genome sequence of strain XH2169 isolated from a blood sample in China. The genome comprises a single circular chromosome with a length of 1,944,282 bp. It harbored 1,891 coding gene sequences, 16 rRNA genes, 60 tRNA genes, and 3 noncoding RNA genes.