Publications by authors named "Yao Liu"

Hepatocellular carcinoma (HCC) is a malignant tumor characterized by rapid progression. To explore the regulatory mechanism of rapid tumor growth and metastasis, we conducted proteomic and scRNA-Seq analyses on advanced HCC tissues and identified a significant molecule, guanine monophosphate synthase (GMPS), closely associated with the immune evasion in HCC. We analyzed the immune microenvironment characteristics remodeled by GMPS using scRNA-Seq and found GMPS induced tumor immune evasion in HCC by impairing the tumor-killing function of CD8  T cells.

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Metal-organic frameworks (MOFs) hold enormous promise for treating bacterial infections to circumvent the threat of antibiotic resistance. However, positioning MOFs on wound dressings is hindered and remains a significant challenge. Herein, a facile heterointerfacial engineering strategy was developed to tailor the "MOF armor" that adaptively weaponized the poly(ε-caprolactone) electrospun dressing with excellent bacteria-killing efficacy.

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Background: The continuous development of social and economic progress and ongoing enhancement of infrastructure construction has led to drastic changes in the occurrence of trauma.

Aim: To analyze the epidemiological characteristics of trauma in Lanzhou City to provide theoretical references for improving quality of trauma care.

Methods: A retrospective analysis of clinical data from 16585 trauma patients treated at the First Hospital of Lanzhou University Trauma Center from November 1, 2021 to October 31, 2023 was conducted.

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The chemical composition and quality of honey are influenced by its botanical, geographic, and entomological origins, as well as climatic conditions. In this study, the physicochemical characteristics, microbial communities, and hydrocarbon compounds of honey produced by , , , , and were elucidated. The physicochemical profile of the honey exhibited significant differences across species, including moisture content (18.

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The clinical application of most natural antimicrobial peptides (AMPs) is hindered by their lack of a synergistic combination of high antibacterial efficacy, low toxicity, and stability, necessitating frequent complex modifications that incur significant labor and economic costs. Therefore, it is imperative to optimize the antibacterial properties of AMPs using some simplified approach. In this study, we designed a library of β-hairpin AMPs with identical β-turn sequences (-D-Pro-Gly-) and varying repetition units (IR, FR, and WK).

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Cenobamate (CNB) is a novel anti-seizure medication with significant efficacy in treating epilepsy. However, in clinical trials, the most common adverse reactions observed in patients are central nervous system (CNS) symptoms. In animal studies, administration of CNB during pregnancy or lactation has been associated with adverse effects on neurodevelopment in offspring.

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Objective: This study aimed to evaluate the clinical utility of methylation (CISCER) test in triaging high-risk human papillomavirus (hrHPV)-positive women.

Methods: We enrolled women who underwent opportunistic screening at Cervical Disease outpatient clinics of Xuzhou Maternity and Child Health Hospital, and Yueyang Central Hospital from December 2022 to May 2024. The effectiveness of CISCER and cytology tests in triaging hrHPV+ patients was analyzed.

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Objectives: To investigate the epidemiological characteristics of Augmented Renal Clearance (ARC) in severe sepsis children with MRSA infection and find risk factors to establish a model predicting ARC onset in PICU.

Design: Retrospective study, in which ARC was defined by estimated glomerular filtration rate (eGFR) measured by the modified Schwartz formula above 130 ml/min/1.73 m.

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Background: This study aimed to compare the different outcomes of mandibular distraction osteogenesis (MDO) using computer-aided design and manufacturing (CAD/CAM) surgical guides accompanied by pre-bent distractors versus CAD/CAM surgical guides with commercial distractors.

Methods: Twenty-eight patients with severe dentofacial deformities secondary to unilateral temporomandibular joint ankylosis (TMJA) were retrospectively enrolled. Ten parameters associated with MDO were measured preoperatively, virtually, and postoperatively.

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Submergence tolerance is a complex trait governed by multiple genetic loci. Arabidopsis thaliana, widely distributed from arid to humid regions, offers an opportunity to explore the underlying genetic components and their interactive mechanisms. In this study, we utilized map-based cloning techniques to identify the WRKY22 genetic locus, which activates RAP2.

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Background: Alzheimer's disease (AD) is a degenerative brain disease without a cure. (LJF), a traditional Chinese herbal medicine, possesses a neuroprotective effect, but its mechanisms for AD are not well understood. This study aimed to investigate potential targets and constituents of LJF against AD.

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Magnetorheological grease (MRG) is considered a promising alternative to magnetorheological fluids as a smart material because of its higher stability and less leakage. To enhance yield stresses in various applications, graphite is incorporated as an additive, resulting in graphite magnetorheological grease (GMRG). However, the nonlinear hysteresis properties of this new material and its prediction methods have not been investigated.

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Background: Hepatocellular carcinoma poses a significant public health burden in China, necessitating the economic evaluation of new therapeutic strategies for policy-makers and clinicians. The international, randomized phase 3 trial CARES-310 revealed that camrelizumab plus rivoceranib provided a substantial clinical benefit in patients with advanced hepatocellular carcinoma, but the economic outcome remains unclear. This study aimed to evaluate the cost-effectiveness of camrelizumab plus rivoceranib versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma (CARES-310) from the perspective of the Chinese health care system.

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Oridonin (Ori) possesses anti-inflammatory properties. However, its potential to treat diabetic retinopathy (DR) remains unclear. This study aimed to investigate the retinal protective function of Ori and the underlying mechanism.

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Article Synopsis
  • - The study focused on identifying risk factors for COVID-19 pneumonia specifically in patients with hematological malignancies (HM) during the Omicron BA.5.2 wave in Chongqing, China.
  • - Among 475 enrolled HM patients, 15.8% developed COVID-19 pneumonia, with significant risk factors including active disease status, incomplete COVID-19 vaccination, recent chemotherapy, and reduced NK-cell counts.
  • - The findings emphasize the need for serious clinical attention for HM patients with these risk factors to better manage potential lung complications following Omicron infection.
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With the growing adoption of hydrogen energy and the rapid advancement of Internet of Things (IoT) technologies, there is an increasing demand for high-performance hydrogen gas (H) sensors. Among various sensor types, chemiresistive H sensors have emerged as particularly promising due to their excellent sensitivity, fast response times, cost-effectiveness, and portability. This review comprehensively examines the recent progress in chemiresistive H sensors, focusing on developments over the past five years in nanostructured materials such as metals, metal oxide semiconductors, and emerging alternatives.

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Article Synopsis
  • Post-translational modifications, like lactylation, are crucial in regulating protein function in bacteria, but their roles in pathogenesis are less understood than in eukaryotes.
  • The study highlights how Staphylococcus aureus modifies proteins by adding lactate to lysine residues, particularly affecting the alpha-toxin, which is key for its virulence.
  • Increased lactate levels during infections may enhance the bacterium's ability to produce toxins, boosting its virulence and making it more dangerous in infection scenarios.
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Objective: This study developed and evaluated a computer-based method for automating the registration of scanned dental models with 3D reconstructed skulls and segmentation of the temporomandibular joint (TMJ).

Methods: A dataset comprising 1274 skull models and corresponding scanned dental models was collected. In total, 1066 cases were used for the development of the computer-based method, while 208 cases were used for validation.

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Congenital portosystemic shunts (CPSS) are rare pediatric vascular malformations characterized by abnormal development of the portal vein, which is attributed to incomplete embryonic remodeling of the hepatic and surrounding vasculature. CPSS manifests in two main forms: intrahepatic and extrahepatic. This study details the management of a pediatric patient diagnosed with Congenital Intrahepatic Portosystemic Shunt (CIPS) who was referred to our institution.

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Article Synopsis
  • African Americans with type 2 diabetes face healthcare disparities, and existing diabetes self-management programs lack cultural relevance; thus, Peers EXCEL was developed to integrate elements from two programs, HLWD and Peers LEAD.
  • The study gathered insights from African American participants and facilitators through focus groups and interviews to evaluate the proposed Peers EXCEL program.
  • Feedback indicated a strong appreciation for the cultural alignment of Peers EXCEL, highlighting the need to address issues like systemic racism and the inclusion of community perspectives in creating effective diabetes management programs.
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