Unlocking the Potential for Methanol Synthesis via Electrochemical CO Reduction Using CoPc-Based Molecular Catalysts.

The electrochemical CO reduction reaction (CORR) to produce methanol (CHOH) is an attractive yet challenging approach due to a lack of selective electrocatalysts. An immobilized cobalt phthalocyanine (CoPc) molecular catalyst has emerged as a promising electrocatalyst for CHOH synthesis, demonstrating decent activity and selectivity through a CO-CO-CHOH cascade reaction. However, CoPc's performance is limited by its weak binding strength toward the CO intermediate.

The Experience of Social Alienation in Elderly Lung Cancer Patients: A Qualitative Study.

Purpose: The aim of this study was to understand the experience of social alienation in elderly lung cancer patients, to explore its causes, and to propose targeted intervention strategies.

Methods: From July to August 2023, 16 elderly lung cancer patients attending the respiratory department of a tertiary hospital in Changsha City, Hunan Province, were selected for semi-structured interviews using a purposive sampling method. The Colaizzi 7-step method was used to analyze the data.

The relationship between adverse childhood experiences and depressive symptoms in rural left-behind adolescents: A cross-sectional survey.

Objective: We assessed the current status of depressive symptoms and the associated factors in rural left-behind adolescents. Moreover, we investigated the relationship between adverse childhood experiences and depressive symptoms.

Methods: Students from two rural junior high schools in Huaihua City were enrolled from July to September 2022.

Confusion Region Mining for Crowd Counting.

Existing works mainly focus on crowd and ignore the confusion regions which contain extremely similar appearance to crowd in the background, while crowd counting needs to face these two sides at the same time. To address this issue, we propose a novel end-to-end trainable confusion region discriminating and erasing network called CDENet. Specifically, CDENet is composed of two modules of confusion region mining module (CRM) and guided erasing module (GEM).

Mechanism of immune escape mediated by receptor tyrosine kinase KIT in thyroid cancer.

Objective: Thyroid cancer (TC) is one of the fastest-growing malignant tumors. This study sought to explore the mechanism of immune escape mediated by receptor tyrosine kinase (KIT) in TC.

Methods: The expression microarray of TC was acquired through the GEO database, and the difference analysis and Kyoto encyclopedia of genes and genomes pathway enrichment analysis were carried out.

Analysis of hot spots and frontiers of nursing scenario simulation teaching research at home and abroad.

Objective: To analyze the research hotspots and trends of nursing scenario simulation teaching at home and abroad, and to provide reference for future nursing talent education.

Methods: CNKI and Web of Science databases were searched. From the establishment of the database to April 2022, relevant literature on nursing scenario simulation teaching research at home and abroad was retrieved, and Cite Space software was used for visual analysis.

Translating Catalyst-Polymer Composites from Liquid to Gas-Fed CO Electrolysis: A CoPc-P4VP Case Study.

The electrochemical CO reduction reaction (CORR) in gas-fed flow electrolyzers using gas diffusion electrodes (GDEs) generates industrially relevant activities and provides a promising approach for carbon recycling. Developing effective catalyst systems on GDEs is critical for achieving high activities. Catalyst-polymer composites (CPCs) formed between immobilized molecular catalysts and coordinating polymers exhibit positive synergies for the enhancement of CORR activity.

Prevalence and factors influencing depression among empty nesters in China: A meta-analysis.

Background: Empty nesters are older people who live alone or an older couple without children to care for them. In China, empty nesters make up a significant community and are more likely to experience emotional issues, particularly depression. This study investigated the prevalence of depression and the factors influencing depression among Chinese home-bound empty nesters using meta-analysis.

NDRG2 inhibits pyruvate carboxylase-mediated anaplerosis and combines with glutamine blockade to inhibit the proliferation of glioma cells.

Due to the rapid proliferation, cancer cells have increased anabolic biosynthesis, which requires anaplerosis to replenish precursor intermediates. The major anaplerotic sources are pyruvate and glutamine, which require the catalysis of pyruvate carboxylase (PC) and glutaminase (GLS) respectively. In GLS-suppressed cancer cells, the PC-mediated pathway for anaplerosis is crucial to maintain cell growth and proliferation.

CD11b + CD43 hi Ly6C lo splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis.

Background And Aims: Monocyte-derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression. The spleen serves as an extra monocyte reservoir in inflammatory conditions; however, the precise mechanisms of involvement of the spleen in the pathogenesis of liver fibrosis remain unclear.

Approach And Results: By splenectomy and splenocyte transfusion, it was observed that splenic CD11b + cells accumulated intrahepatically as Ly6C lo MoMFs to exacerbate CCl 4 -induced liver fibrosis.

PRMT5 regulates RNA m6A demethylation for doxorubicin sensitivity in breast cancer.

Cancer cells respond to various stressful conditions through the dynamic regulation of RNA m6A modification. Doxorubicin is a widely used chemotherapeutic drug that induces DNA damage. It is interesting to know whether cancer cells regulate the DNA damage response and doxorubicin sensitivity through RNA m6A modification.

Non-thermal plasma-assisted rapid hydrogenolysis of polystyrene to high yield ethylene.

The evergrowing plastic production and the caused concerns of plastic waste accumulation have stimulated the need for waste plastic chemical recycling/valorization. Current methods suffer from harsh reaction conditions and long reaction time. Herein we demonstrate a non-thermal plasma-assisted method for rapid hydrogenolysis of polystyrene (PS) at ambient temperature and atmospheric pressure, generating high yield (>40 wt%) of C-C hydrocarbons and ethylene being the dominant gas product (Selectivity of ethylene, S > 70%) within ~10 min.

An Electrochemical Ethylamine/Acetonitrile Redox Method for Ambient Hydrogen Storage.

Hydrogen storage presents a major difficulty in the development of hydrogen economy. Herein, we report a new electrochemical ethylamine/acetonitrile redox method for hydrogen storage with an 8.9 wt % theoretical storage capacity under ambient conditions.

NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.

Background: Paracellular barriers play an important role in the pathogenesis of Inflammatory bowel disease (IBD) and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumour suppressor gene and to inhibit colorectal cancer metastasis. However, whether NDRG2 affects colitis initiation and colitis-associated colorectal cancer is unclear.

Properties of amorphous iron phosphate in pseudocapacitive sodium ion removal for water desalination.

Capacitive deionization (CDI) is an energy saving and environmentally friendly technology for water desalination. However, classical CDI is challenged by a low salt removal capacity. To improve the desalination capacity, electrode materials utilizing the battery mechanism for salt ion removal have emerged as a new direction more recently.

MIIP inhibits EMT and cell invasion in prostate cancer through miR-181a/b-5p-KLF17 axis.

Growing evidence have shown that the migration and invasion inhibitory protein (MIIP, also known as IIp45) functions as a tumor suppressor and its expression is downregulated in several types of cancer, yet the function of MIIP in prostate cancer (PCa) and the underlying mechanism of action remains largely unknown. Here we demonstrated that MIIP acts as a suppressor of PCa by inhibiting epithelial-mesenchymal transition (EMT) and cell invasion. Overexpressing MIIP repressed cellular invasion of PC3 and DU145 in vitro, accompanied by a decrease of EMT-inducing factors, and an increase of E-cadherin and KLF17.

A vacuum impregnation method for synthesizing octahedral PtCuNi nanoparticles on mesoporous carbon support and the oxygen reduction reaction electrocatalytic properties.

Mesoporous carbon (MPC) nanomaterials, with large specific surface area, excellent conductivity and stability, and effective mass transfer are beneficial for use as catalyst support in electrochemical oxygen reduction reaction (ORR) for fuel cell applications. However, MPC utilization was limited by difficulties in loading catalyst nanoparticles within the MPC pores while simultaneously controlling critical particle parameters such as size and distribution. In this study we report a new vacuum impregnation method combined with solid-state chemistry synthesis for preparing highly active ORR catalyst nanoparticles on MPC supports.

Combined Aberrant Expression of NDRG2 and LDHA Predicts Hepatocellular Carcinoma Prognosis and Mediates the Anti-tumor Effect of Gemcitabine.

The Warburg effect is one of the important hallmarks of cancer. The activation of oncogene and inactivation of tumor suppressor gene contribute to the enhancement of glycolytic enzymes and the Warburg effect. The N-myc downstream regulated gene 2 (NDRG2) is a tumor suppressor gene and is frequently lost in various types of cancer.

The tumor suppressor NDRG2 cooperates with an mTORC1 inhibitor to suppress the Warburg effect in renal cell carcinoma.

Renal cell carcinoma (RCC) is one of the most common malignancies worldwide, and metabolic reprogramming has a profound effect on RCC tumorigenesis. mTORC1 inhibitors are widely used in RCC treatment, yet some types of RCC cells are resistant to these compounds. Thus, clarification of the metabolic mechanism of mTORC1 inhibitors and exploration of new therapeutic approaches are urgently needed.

A New Role for the Spleen: Aggravation of the Systemic Inflammatory Response in Rats with Severe Acute Pancreatitis.

Little is known about the role of the spleen in mediating systemic inflammatory responses in severe acute pancreatitis (SAP). We investigated the role played by the spleen in rats after SAP induction. Splenectomy was performed at designated time points after SAP induction.

NDRG2 Protects the Brain from Excitotoxicity by Facilitating Interstitial Glutamate Uptake.

Glutamate is a prominent neurotransmitter responsible for excitatory synaptic transmission and is taken up by sodium-dependent excitatory amino acid transporters (EAATs) on astrocytes to maintain synaptic homeostasis. Here, we report that N-myc downstream regulated gene 2 (NDRG2), a known tumor suppressor, is required to facilitate astroglial glutamate uptake and protect the brain from glutamate excitotoxicity after ischemia. NDRG2 knockout (Ndrg2) mice exhibited an increase in cerebral interstitial glutamate and a reduction in glutamate uptake into astrocytes.

Dual-Site Cascade Oxygen Reduction Mechanism on SnO /Pt-Cu-Ni for Promoting Reaction Kinetics.

Designing highly active oxygen reduction reaction (ORR) catalysts is crucial to boost the fuel cell economy. Previous research has mainly focused on Pt-based alloy catalysts in which surface Pt is the solely active site and the activity improvement was challenged by the discovered scaling relationship. Herein we report a new concept of utilizing dual active sites for the ORR and demonstrate its effectiveness by synthesizing a SnO /Pt-Cu-Ni heterojunctioned catalyst.

Effect of PTEN loss on metabolic reprogramming in prostate cancer cells.

The tumor suppressor gene PTEN is one of the most often deleted genes in human prostate cancer. Loss of PTEN is an important event in prostate carcinogenesis. Metabolic reprogramming induced by PTEN loss fuels malignant growth and proliferation of prostate cancer cells.

A Novel Ship-Tracking Method for GF-4 Satellite Sequential Images.

The geostationary remote sensing satellite has the capability of wide scanning, persistent observation and operational response, and has tremendous potential for maritime target surveillance. The GF-4 satellite is the first geostationary orbit (GEO) optical remote sensing satellite with medium resolution in China. In this paper, a novel ship-tracking method in GF-4 satellite sequential imagery is proposed.