Publications by authors named "Yao Hsien Tseng"
Aim: Hyperglycemia was found to be associated with an increased risk of cancer in a general population cohort. However, it remains to be established whether the severity of diabetic complications is associated with cancer risk in patients with diabetes.
Materials And Methods: We used the National Health Insurance Research Database from 2000 through 2013, including those with newly diagnosed diabetic patients (n = 616,742).
Article Synopsis
- The study investigates the unclear relationship between Hashimoto thyroiditis and papillary thyroid cancer (PTC), where thyroid cancer cases are on the rise but typically grow slowly and can be treated successfully.
- Researchers identified 70 differentially expressed genes (DEGs) and honed in on four key genes (CXCR4, IL6ST, PPARG, TP53) that may serve as important biomarkers for linking thyroiditis with thyroid cancer.
- The findings highlight the significance of these four genes, suggesting they warrant further research to better understand their roles in these thyroid diseases.
Mucosa-associated lymphoid tissue lymphoma of thyroid and adrenal glands with primary adrenal insufficiency.
Endocrinol Diabetes Metab Case Rep
January 2024
Summary: A 69-year-old woman presented with weight loss, fever, dizziness, exertional dyspnea, and drenching night sweats. Imaging showed a thyroid goiter at the left lobe that measured 5.6 × 3.
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- A study was conducted to explore the link between aristolochic acid (AA) in Chinese herbal products and cancer risk in diabetic patients, as previous research had not addressed this correlation.
- Using data from Taiwan's National Health Insurance Research Database, researchers tracked diabetes patients over several years to analyze cancer incidences and patterns related to AA exposure.
- The findings indicated a significant increase in cancer risk - including for kidney, bladder, liver, and prostate cancers - among those exposed to AA, with women also facing heightened risks for extrahepatic bile duct cancer at higher doses.
Background: The aim of the present study was to examine the association between glycemic excursions before treatment and HbA1c reduction after treatment intensification with acarbose or glibenclamide in patients with type 2 diabetes (T2D).
Methods: Patients receiving single or dual oral antidiabetic drug treatment with an HbA1c of 7.0-11.
Article Synopsis
- The study aimed to explore how glycemic fluctuations relate to the duration of low blood sugar episodes following intensified treatment in patients with type 2 diabetes (T2D).
- Patients were treated with metformin and then randomly assigned to either glibenclamide or acarbose; their glucose levels were monitored continuously over the study period.
- Results indicated that using glibenclamide significantly increased the time spent in hypoglycemia, and greater glycemic fluctuations were linked to longer hypoglycemia duration, emphasizing the need to manage glycemic excursions in T2D treatment.
Objective: Acarbose, an α-glucosidase inhibitor, has been shown to have antineoplastic effects on colorectal cancer in biomarker studies. We assessed the association between acarbose use in patients with diabetes and incident colorectal cancer.
Research Design And Methods: We conducted a nationwide, population-based study using a large cohort with diabetes in the Taiwan National Health Insurance Research Database.
Article Synopsis
- This study investigated factors that predict effective control of HbA1c levels in patients with type 2 diabetes not adequately managed by metformin alone.
- A group of 51 patients received either glibenclamide or acarbose for 16 weeks, and their insulin secretion and sensitivity were evaluated through tests before and after treatment.
- The results showed significant reductions in HbA1c levels and improvements in beta-cell function, with better outcomes linked to higher baseline beta-cell function reserves.
Background/purpose: Cardiovascular complication is the leading cause of mortality in patients with diabetes. Dyslipidemia and hypertension are the major risk factors contributing to cardiovascular disease (CVD). This study was carried out to investigate the prevalence of dyslipidemia and hypertension and their associations with microvascular and macrovascular complications in patients with type 2 diabetes in Taiwan.
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- * It includes T2DM outpatients aged 30 to 70 who have been on oral antidiabetic medications and evaluates outcomes such as mean amplitude of glycemic excursions (MAGE) and markers of oxidative stress over a total of 24 weeks.
- * A total of 55 patients were included in the study, with results aimed at understanding how different medications impact glucose levels and related complications in diabetes.
Article Synopsis
- The study aimed to assess the relationship between metabolic syndrome (MS) and bone mineral density (BMD) among 820 participants in Taiwan, primarily focusing on men and women aged around 70 and 68, respectively.
- Findings indicated that while a significant number of participants had MS (33.0% men, 44.2% women), the condition did not correlate with bone mineral loss in either gender.
- Factors such as lower diastolic blood pressure and triglyceride levels in participants with MS were linked to bone mineral loss in men, but overall, MS did not appear to affect BMD significantly.
Article Synopsis
- A dual-operation-mode liquid crystal lens is created using silica nanoparticle-doped hybrid-aligned nematic liquid crystals.
- When an AC voltage is applied, the lens acts like a typical liquid crystal lens, but it responds faster due to the silica nanoparticles decreasing the dielectric relaxation time.
- With DC voltage, the lens can perform as a bistable liquid crystal lens due to the movement of the silica nanoparticles and the formation of agglomerate networks on the surface.