Background And Purpose: Recent studies link pesticide exposures to cardiovascular disease risk factors. However, research on the combined effects of multiple pesticides on atherosclerotic cardiovascular disease (ASCVD) is limited, particularly in rural areas. Despite advances in toxicogenomics, the mechanisms underlying these effects remain unclear.
View Article and Find Full Text PDFPhotoacoustic microscopy (PAM) has gained increasing popularity in biomedical imaging, providing new opportunities for tissue monitoring and characterization. With the development of deep learning techniques, convolutional neural networks have been used for PAM image resolution enhancement and denoising. However, there exist several inherent challenges for this approach.
View Article and Find Full Text PDFMeroterpenoids in the traditional Chinese medicine Arnebia euchroma are thought to be key components in its anti-inflammatory activity. In the present study, 17 meroterpenoids including four types of structural skeletons (1-17), together with a monoterpenoid (18), were isolated from the roots of A. euchroma.
View Article and Find Full Text PDFJuvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative neoplasm occurring in infants and young children. JMML has been shown to be resistant to all conventional cytotoxic chemotherapy drugs, and current curative therapies still rely on hematopoietic stem cell transplantation, which carries a high risk of relapse post-transplantation. This underscores the urgent need for novel treatment strategies.
View Article and Find Full Text PDFDevices based on transition metal dichalcogenide nanotubes hold great potential for electronic and optoelectronic applications. Herein, the electrical transport and photoresponse characteristics of a back-gate device with a channel made of a single tungsten disulfide (WS) nanotube are investigated as functions of electric stress, ambient pressure, and illumination. As a transistor, the device exhibits p-type conduction, which can be transformed into ambipolar conduction at a high drain-source voltage.
View Article and Find Full Text PDFBackground: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in school-aged children. The lack of objective biomarkers for ADHD often results in missed diagnoses or misdiagnoses, which lead to inappropriate or delayed interventions. Eye-tracking technology provides an objective method to assess children's neuropsychological behavior.
View Article and Find Full Text PDFVacancy engineering effectively modulates the electronic properties of electrode materials, thereby improving their electrochemical performance. In this study, we prepared selenium-deficient NiCoSe (Se-NCS) using ethylene glycol as a reducing agent in NaOH alkaline environment, and investigated its potential as an electrode material for supercapacitors. Both theoretical and experimental results confirmed that the introduction of vacancies altered the morphology and electronic structure of NiCoSe, which in turn synergistically improved the conductivity and the diffusion capability of electrolyte ions.
View Article and Find Full Text PDFDue to the radial network structures, small cross-sectional lines, and light loads characteristic of existing AC distribution networks in mountainous areas, the development of active distribution networks (ADNs) in these regions has revealed significant issues with integrating distributed generation (DGs) and consuming renewable energy. Focusing on this issue, this paper proposes a wide-range thyristor-controlled series compensation (TCSC)-based ADN and presents a deep reinforcement learning (DRL)-based optimal operation strategy. This strategy takes into account the complementarity of hydropower, photovoltaic (PV) systems, and energy storage systems (ESSs) to enhance the capacity for consuming renewable energy.
View Article and Find Full Text PDFBackground: To investigate the prognostic differences following the achievement of a pathological complete response (pCR) through neoadjuvant chemotherapy across different molecular subtypes of breast invasive ductal carcinoma.
Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) were identified for patients undergoing neoadjuvant chemotherapy who achieved pathological complete response for invasive ductal carcinoma of the breast between 2010 and 2019.Comparing the clinicopathological characteristics of patients across different molecular subtypes.
Objective: The guidelines recommend early caffeine administration for preterm infants requiring non-invasive mechanical ventilation since earlier treatment is associated with better outcomes. The objective was to evaluate the impact of early caffeine therapy (within 24 hours after birth) on respiratory outcomes in very preterm infants who were initially receiving invasive mechanical ventilation.
Methods: This was an observation cohort study from 1 January 2018 to 31 December 2022 based on a database that was prospectively collected and maintained.
Algae are highly sensitive to environmental factors, especially nutrient fluctuations; excessive nutrients can lead to the proliferation of specific algae species, resulting in dominance. In this study, we aimed to reevaluate changes in algal dominance from the perspective of resource utilization efficiency (RUE). We established 80 monitoring sites across different water systems, collecting water and phytoplankton samples.
View Article and Find Full Text PDFTo address the problem of the low nitrogen (N) content of carbon materials prepared through the direct carbonization of food waste, soybean meal and egg whites with high N contents were selected to carry out carbonization experiments on food waste. At 220 °C, the effects of hydrothermal carbonization and microwave carbonization on the properties of supercapacitor electrode materials were investigated. The results show that food waste doped with soybean meal and egg whites could achieve good N doping.
View Article and Find Full Text PDFThere is no evidence on the associations between persistent organic pollutants (POPs) and the incidence of chronic kidney disease (CKD) in the Chinese rural population. We aimed to investigate the individual and mixed effects of 22 POPs on the prevalence and incidence of CKD, and the joint effects of POPs and abnormal glucose metabolism as well as the modification effects of healthy lifestyle on these associations. A total of 2775 subjects, including 925 subjects with normal plasma glucose (NPG) and 925 subjects with prediabetes (PDM) and type 2 diabetes mellitus (T2DM), were enrolled from the Henan Rural Cohort Study.
View Article and Find Full Text PDFHematite (α-FeO) has become a research hotspot in the field of photoelectrochemical water splitting (PEC-WS), but the low photogenerated carrier separation efficiency limits further application. The electronic structure regulation, such as element doping and organic functional groups with different electrical properties, is applied to alleviate the problems of poor electrical conductivity, interface defects, and band mismatch. Herein, α-FeO photoanodes are modified to regulate their electric structures and improve photogenerated carrier transport by the bimetallic metal-organic frameworks (MOFs), which are constructed with Fe/Ni and terephthalate (BDC) with 2-substitution of different organic functional groups (─H, ─Br, ─NO and ─NH).
View Article and Find Full Text PDFThe prompt and precise identification of hemodynamically significant coronary artery lesions remains an ongoing challenge. This study investigated the diagnostic value of non-invasive global left ventricular myocardial work indices by echocardiography in functional status of coronary artery disease (CAD) patients with myocardial ischemia using fractional flow reserve (FFR) as the gold standard. A total of 77 consecutive patients with clinically suspected CAD were prospectively enrolled.
View Article and Find Full Text PDFLinear alkylbenzene sulfonate (LAS) is one of the most widely used anionic surfactants and a common toxic pollutant in wastewater. This study employed high throughput sequencing to explore the microbial community structure within activated sludge exposed to a high concentration of LAS. Genera such as Pseudomonas, Aeromonas, Thauera and Klebsiella exhibited a significant positive correlation with LAS concentrations.
View Article and Find Full Text PDFThe development of tin-lead alloyed halide perovskite nanocrystals (PNCs) is highly desirable for creating ultrastable, eco-friendly optoelectronic applications. However, the current incorporation of tin into the lead matrix results in severe photoluminescence (PL) quenching. To date, the precise atomic-scale structural origins of this quenching are still unknown, representing a significant barrier to fully realizing the potential of these materials.
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