From Tea to Functional Foods: Exploring Bunge for Anti-Rheumatoid Arthritis and Unraveling Its Potential Mechanisms.

Background: Bunge (CM) shows promising potential for managing rheumatoid arthritis (RA) and digestive disorders, attributed to its rich content of bioactive compounds such as polyphenols and flavonoids. Despite its common use in herbal tea, the specific mechanisms underlying CM's anti-inflammatory and joint-protective effects remain unclear, limiting its development as a functional food. This study investigated the effects of aqueous CM extract on RA in collagen-induced arthritis (CIA) rats and explored the underlying mechanisms.

HTT1, a Stearoyl-Acyl Carrier Protein Desaturase Involved Unsaturated Fatty Acid Biosynthesis, Affects Rice Heat Tolerance.

Elucidating the mechanisms underlying heat tolerance in rice (Oryza Sativa. L) is vital for adapting this crop to rising global temperature while increasing yields. Here, we identified a rice mutant, high temperature tolerance 1 (htt1), with high survival rates under heat stress.

An ensemble learning method combined with multiple feature representation strategies to predict lncRNA subcellular localizations.

Long non-coding RNAs (lncRNAs) are strongly associated with cellular physiological mechanisms and implicated in the numerous diseases. By exploring the subcellular localizations of lncRNAs, we can not only gain crucial insights into the molecular mechanisms of lncRNA-related biological processes but also make valuable contributions towards the diagnosis, prevention, and treatment of various human diseases. However, conventional experimental techniques tend to be laborious and time-intensive.

Stromal immune cells expression of Siglec-15 is associated with lower T stage and better prognosis of urinary bladder cancer.

Introduction: Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a novel immune checkpoint, similar to programmed death-ligand (PD-L1), and has emerged as a potential target for cancer immunotherapy. Until recently, little was known about the expression and role of Siglec-15 in bladder cancer (BC).

Methods: In this study, we used immunohistochemical staining to assess the expression of Siglec-15 and PD-L1 in 69 primary BC samples and analyzed their relationship with clinicopathologic characters and prognosis.

A Dual-Functional Sulfur-Rich Copolymers for Stable Anchoring and Enhanced Conversion of Polysulfide in Lithium-Sulfur Batteries.

Sulfur-rich copolymers have gained a great deal of attention as promising cathode materials in Li-S batteries due to their low cost and naturally uniform sulfur dispersion. However, the poor electrical conductivity and shuttle effect cause rapid capacity decay and low sulfur utilization especially under high sulfur loading and low electrolyte/sulfur ratio. Herein, the FeS/C dispersed and Se-containing sulfur-rich copolymer (FSP) was synthesized by one-pot reaction of ferrocene, trithiocyanuric acid with SeS.

Unveiling relationships of human instinctive behaviors and blood pressure in Chinese adults: A network analysis.

Objectives: Human behaviors and blood pressure (BP) are closely intertwined, affecting health. However, few studies have demonstrated their complex relationships. Using network analysis, we aimed to untangle the intricate and potential causal relationships between BP and human instinctive behaviors, identifying potential action points for hypertension prevention and control.

Ga-PSMA PET/CT-Based Model Predicts Perineural Invasion of Prostate Cancer with Whole-Mount Sections.

Purpose: To develop a novel risk model incorporating Ga-PSMA PET/CT parameters for prediction of perineural invasion (PNI) of prostate cancer (PCa).

Methods: The study retrospectively enrolled 192 PCa patients with preoperative multiparametric MRI, Ga-PSMA PET/CT and radical specimen. Imaging parameters were derived from both mpMRI and PET/CT images.

Quantitative Insight into the Electric Field Effect on CO Electrocatalysis via Machine Learning Spectroscopy.

During chemical reactions, especially for electrocatalysis and electrosynthesis, the electric field is the most central driving force to regulate the reaction process. However, due to the difficulty of quantitatively measuring the electric field effects caused at the microscopic level, the regulation of electrocatalytic reactions by electric fields has not been well digitally understood yet. Herein, we took the infrared/Raman spectral signals of CO molecules as descriptors to quantitatively predict the effects of different electric fields on the catalytic properties.

Single-tube detection of a foodborne bacterial pathogen using user-friendly portable device.

Timely and reliable detection of foodborne bacterial pathogen is crucial for reducing disease burden in low- and middle-income countries. However, laboratory-based methods are often inaccessibility in resource-limited settings. Here, we developed a single-tube assay and a low-cost palm-sized device for on-site detection of the representative foodborne bacterial pathogen, Salmonella Enteritidis.

AI-Powered cellular morphometric biomarkers discovered in needle biopsy of prostatic cancer predict neoadjuvant androgen deprivation therapy response and prognosis: an international multicenter retrospective study.

Unlabelled: It is imperative to identify patients with prostate cancer (PCa) who will benefit from androgen receptor signaling inhibitors that can impact quality of life upon prolonged use. Using our extensively-validated artificial-intelligence technique: cellular morphometric biomarker via machine learning (CMB-ML), we identified 13 CMBs from whole slide images of needle biopsies from the trial specimens ( NCT02430480 , n=37) that accurately predicted response to neoadjuvant androgen deprivation therapy (NADT) (AUC: 0.980).

Bound state in the continuum enabled ultralong silicon ridge waveguide grating antennas for integrated LiDAR applications.

As a novel method for solid-state light detection and ranging (LiDAR), optical phased arrays (OPAs) cater to the growing market requirement for mass-produced chip-scale beam steering devices. Waveguide grating antennas (WGAs) with low loss, high efficiency and large emitting aperture are strongly desirable to achieve low beam divergence and high resolution for OPAs. In this paper, we report two kinds of silicon ridge-waveguide-based WGAs with ultra-sharp instantaneous field-of-view (IFOV) for LiDAR applications.

Correlation analysis of landscape patterns and urban thermal environment in Kunming based on a panel data model.

With the development of urbanization, the spatial and temporal distribution characteristics of the urban landscape pattern play a decisive role in the intensity of the urban heat island (UHI) effect. A panel data model was constructed to study the relationship between the UHI effect and landscape pattern in Kunming from 1995 to 2020 at four different scales. The results indicate: (1) The landscape pattern of Kunming changed obviously with time, the artificial patch increased, the natural patch decreased, and the UHI effect became more and more obvious; (2) With an increase in scale, the number of influencing variables continues to grow, and the impact of artificial patches gradually intensifies; (3) The normalized difference water index (NDWI) has the greatest influence on the UHI, and the cooling effect is more obvious with the increase in scale.

Data-Based Prediction of Redox Potentials via Introducing Chemical Features into the Transformer Architecture.

Rapid and accurate prediction of basic physicochemical parameters of molecules will greatly accelerate the target-orientated design of novel reactions and materials but has been long challenging. Herein, a chemical language model-based deep learning method, TransChem, has been developed for the prediction of redox potentials of organic molecules. Embedding an effective molecular characterization (combining spatial and electronic features), a nonlinear molecular messaging approach (Mol-Attention), and a perturbation learning method, TransChem, shows high accuracy in predicting the redox potential of organic radicals comprising over 100,000 data ( > 0.

mA/YTHDF2-mediated mRNA decay targets TGF-β signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs.

Quiescence acquisition of proliferating neural stem cells (NSCs) is required to establish the adult NSC pool. The underlying molecular mechanisms are not well understood. Here, we showed that conditional deletion of the mA reader Ythdf2, which promotes mRNA decay, in proliferating NSCs in the early postnatal mouse hippocampus elevated quiescence acquisition in a cell-autonomous fashion with decreased neurogenesis.

Regulation of terrestrial input and ocean processes on the occurrence and transport of traditional and emerging per- and polyfluoroalkyl substances in the inner shelf of the East China Sea.

Coastal oceans, serving as transitional zones between land and sea, possess unique geographical features and complex hydrological conditions, functioning as regional reservoirs and crucial transport pathways for anthropogenic pollutants such as per- and polyfluoroalkyl substances (PFASs) to the open ocean. This study comprehensively investigates traditional perfluoroalkyl carboxylic and sulphonic acids (PFCAs and PFSAs) and emerging perfluoroalkyl ether carboxylic and sulfonic acids (PFECAs and PFESAs), fluorotelomer sulfonates (FTSAs) in seawater columns and surface sediments from the inner shelf of the East China Sea, by integrating hydrological and biogeochemical data. Comparable levels of traditional and emerging PFASs were observed in seawater samples, in contrast to higher concentrations of traditional PFASs in surface sediments.

Inhibitory effects characteristics of polysaccharide of Polygonati Rhizome on cytochrome P450 enzymes.

Purpose: As the major active ingredient of Polygonatum sibriricum Red., polysaccharide of Polygonati Rhizome (PSP) has been reported to possess various pharmacological activities, especially for the treatment of chronic disorders in the elderly. This study evaluated the effect of PSP on the activities of major cytochrome P450 enzymes (CYP450) isoforms, aiming to provide theoretical reference for its co-prescription with other drugs and prevent the risk of adverse drug-drug interaction.

CaF Nanoparticle-Induced γ-CsPbIBr Heterogeneous Crystallization for High-Efficiency Flexible All-Inorganic Perovskite Solar Cells.

All-inorganic CsPbI films necessitate higher annealing temperatures for high-quality crystallization. Consequently, the conventional low-temperature solution approach often results in poor crystallization in flexible CsPbI films, significantly degrading the optoelectronic performance and stability of flexible perovskite solar cells (f-PSCs). Herein, a heterogeneous CaF nanocrystal seed-induced strategy has been successfully utilized to achieve enhanced crystallization of a flexible CsPbIBr film.

An integrative pan-cancer analysis of MASP1 and the potential clinical implications for the tumor immune microenvironment.

Mannose-binding lectin-associated serine protease 1 (MASP1) plays a crucial role in the complement lectin pathway and the mediation of immune responses. However, comprehensive research on MASP1 across various cancer types has not been performed to date. This study aimed to evaluate the significance of MASP1 in pan-cancer.

Phytic acid-loaded polyvinyl alcohol hydrogel promotes wound healing of injured corneal epithelium through inhibiting ferroptosis.

As the important barrier of intraocular tissue, cornea is easy to suffer various kinds of injuries. Among them, acute alkali burn is a thorny ophthalmic emergency event, which can lead to corneal persistent epithelial defects, ulcers, and even perforation. Ferroptosis, a mode of regulatory cell death, has been found to play a key role in the process of corneal alkali burn, of which lipid peroxidation and intracellular iron levels are considered to be the possible therapeutic targets.