Silencing Cardiac Troponin I-Interacting Kinase Reduces Lipopolysaccharide-Induced Sepsis-Induced Myocardial Dysfunction in Rat by Regulating Apoptosis-Related Proteins.

The aim of this study was to investigate the effect of cardiac troponin I-interacting kinase () on sepsis-induced myocardial dysfunction (SIMD) and further explore the underlying molecular mechanisms. In this study, a lipopolysaccharide- (LPS-) induced myocardial injury model was used. qRT-PCR was performed to detect the mRNA expression of .

miR-429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β-catenin signaling pathway.

Osteosarcoma (OS) is the most commonly diagnosed malignant cancer of bone that occurs in adolescents and children. Mounting number of studies have indicated that miRNAs are increasingly playing fundamental roles in OS development. Thus, the biological function of miR-429 in OS progression was explored.

A facile synthesis of FeO/nitrogen-doped carbon hybrid nanofibers as a robust peroxidase-like catalyst for the sensitive colorimetric detection of ascorbic acid.

In recent years, the fabrication of functional nanostructures with multicomponents for a variety of novel biosensors has received considerable attention due to their synergistic improved sensitivity. Herein, we report a facile approach for the preparation of FeO/nitrogen-doped carbon (FeO/N-C) hybrid nanofibers, and construct a sensing platform for the sensitive colorimetric detection of HO and ascorbic acid (AA). During the synthetic process, a discontinuous layer of polypyrrole (PPy) is first polymerized in situ on the surface of the α-FeO nanofibers under hydrothermal reaction using α-FeO nanofibers as both a template and an oxidant.

Self-Assembly Fabrication of Coaxial Te@poly(3,4-ethylenedioxythiophene) Nanocables and Their Conversion to Pd@poly(3,4-ethylenedioxythiophene) Nanocables with a High Peroxidase-like Activity.

Here, we report a simple one-step procedure to fabricate coaxial Te@poly(3,4-ethylenedioxythiophene) (PEDOT) nanocables via a self-assembly redox polymerization between 3,4-ethylenedioxythiophene monomer and the oxidant of sodium tellurite without the assistance of any templates and surfactants. The as-synthesized Te@PEDOT coaxial nanocables have diameters of center cores in the range of 5-10 nm, and the size of the outer shell from several nanometers to 15 nm. More interestingly, the as-prepared Te@PEDOT nanocables can be converted to Pd@PEDOT nanocables via a galvanic replacement reaction.