Self-assembled doxorubicin prodrug riding on the albumin express train enable tumor targeting and bio-activation.

Doxorubicin (DOX) is a vital anthracycline chemotherapeutic drug, yet presenting significant challenges due to its severe cardiotoxicity. While Doxil enhances the pharmacokinetics and reduces the cardiotoxicity of DOX solution (DOX sol), it shows limitations of low drug loading capacity and inadequate cellular uptake. To overcome these issues, this study developed a novel disulfide bond-linked DOX-maleimide prodrug (DSSM).

Residual Stress Analysis at the Conductor-Insulator Interface During the Curing Process of Hair-Pin Motors.

The curing process of hair-pin motor stator insulation is critical, as residual stress increases the risk of partial discharge and shortens a motor's lifespan. However, studies on the stress-induced defects during insulation varnish curing remain limited. This research integrates three-dimensional numerical simulations and experimental analysis to develop a curing model based on unsaturated polyester imide resin, aiming to explore the mechanisms of residual stress formation and optimization strategies.

Facile synthesis of CuInGaS₂ quantum dot nanoparticles for bilayer-sensitized solar cells.

CuIn(0.7)Ga(0.3)S2 quantum dots (QDs) with particle size of 2-5 nm were directly synthesised by a vacuum one-pot-nanocasting process and homogeneously anchored on TiO2 nanocrystals (<50 nm) for the first time.

[Synthesis and fluorescence properties of europium complexes with 4-(4-pyridyl formoyl) benzoic acid].

Three new europium complexes, Eu(PFBA)3 (H2O)4, Eu(PFBA)3 Phen (H2O)3 and Eu(PFBA)3 TPPO (H2O)3, were synthesized using 4-(4-pyridyl formoxyl) benzoic acid (HPFBA), 1,10-phenanthroline (phen) and triphenyl phosphine oxide (TPPO) as the ligands. In the complexes, two characteristic absorption bands of HPFBA due to vO-H (3 000-2 200 cm(-1)) and v c=o (1 697 cm(-1)) disappear, the asymmetry stretching vibration v(as)(coo-) and symmetry stretching vibration v(s)(coo-) of carboxyl appear, and the deltav(v(as)(coo)) - v(s)(coo-)) values are all smaller than that of NaPFBA. The carboxyl group of the ligand HPFBA is dehydrogenated and coordinated to Eu3+ with a bidentate chelating mode.