Genetic and therapeutic for oral lichen planus and diabetes mellitus: a comprehensive study.

Background: This study employed a bidirectional Mendelian Randomization (MR) approach to explore the causal relationships between Oral Lichen Planus (OLP), diabetes mellitus (DM), and glycemic control. It also aims to identify potential pharmacological and herbal treatments that effectively address both OLP and the metabolic dysfunctions associated with DM.

Methods: This study employs a two-way MR approach to investigate the potential causal relationships between diabetes type and glycated hemoglobin (HbA1c) levels, and the risk of OLP.

Catalyst Selection over an Electrochemical Reductive Coupling Reaction toward Direct Electrosynthesis of Oxime from NO and Aldehyde.

Aqueous electrochemical coupling reactions, which enable the green synthesis of complex organic compounds, will be a crucial tool in synthetic chemistry. However, a lack of informed approaches for screening suitable catalysts is a major obstacle to its development. Here, we propose a pioneering electrochemical reductive coupling reaction toward direct electrosynthesis of oxime from NO and aldehyde.

Sources and transport of CO in the karst system of Jiguan Cave, Funiu Mountains, China.

Conveyance and modification of carbon-isotope signals within the karst system remain difficult to constrain, due to the complexity of interactions between multiple components, including precipitation, bedrock, soil, atmosphere, and biota. Cave monitoring is thus critical to understanding both their transport in the karst system and dependence on local hydroclimatic conditions. Jiguan Cave, located in Funiu Mountain in central China, is representative of karst tourist caves with relatively thin epikarst zone.

Altered Gut Microbiota and Short-chain Fatty Acids in Chinese Children with Constipated Autism Spectrum Disorder.

Gastrointestinal symptoms are more prevalent in children with autism spectrum disorder (ASD) than in typically developing (TD) children. Constipation is a significant gastrointestinal comorbidity of ASD, but the associations among constipated autism spectrum disorder (C-ASD), microbiota and short-chain fatty acids (SCFAs) are still debated. We enrolled 80 children, divided into the C-ASD group (n = 40) and the TD group (n = 40).

Electrocatalytic Synthesis of Nylon-6 Precursor at Almost 100 % Yield.

Synthesis of cyclohexanone oxime via the cyclohexanone-hydroxylamine process is widespread in the caprolactam industry, which is an upstream industry for nylon-6 production. However, there are two shortcomings in this process, harsh reaction conditions and the potential danger posed by explosive hydroxylamine. In this study, we presented a direct electrosynthesis of cyclohexanone oxime using nitrogen oxides and cyclohexanone, which eliminated the usage of hydroxylamine and demonstrated a green production of caprolactam.

Coupling CO-to-Ethylene Reduction with the Chlor-Alkaline Process in Seawater through In Situ-Formed Cu Catalysts.

The overall commercial value of a CO electroreduction system is hindered by the valueless product and high energy consumption of the oxygen evolution reaction (OER) at the anode. Herein, with an in situ-formed copper catalyst, we employed the alternative chlorine evolution reaction for OER, and high-speed formation of both C2 products and hypochlorite in seawater can be realized. The EDTA in the sea salt electrolyte can trigger an intense dissolution and deposition of Cu on the surface of the electrode, resulting in the in situ formation of dendrites of Cu with high chemical activity.

Monitoring surface dynamics of electrodes during electrocatalysis using in situ synchrotron FTIR spectroscopy.

Monitoring the surface dynamics of catalysts under working conditions is important for a deep understanding of the underlying electrochemical mechanisms towards efficient energy conversion and storage. Fourier transform infrared (FTIR) spectroscopy with high surface sensitivity has been considered as a powerful tool for detecting surface adsorbates, but it faces a great challenge when being adopted in surface dynamics investigations during electrocatalysis due to the complication and influence of aqueous environments. This work reports a well designed FTIR cell with tunable micrometre-scale water film over the surface of working electrodes and dual electrolyte/gas channels for in situ synchrotron FTIR tests.

Mechanism of Huashi Xingyu Qingre recipe in treating oral lichen planus based on network pharmacology and clinical trial verification.

Objective: To identify the main active components and targets of Huashi Xingyu Qingre recipe (, HXQR) and to investigate its mechanism in the treatment of oral lichen planus (OLP).

Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was searched to identify the active ingredients and corresponding targets of HXQR. Disease genes were obtained from the GeneCards database, and a "drug-disease regulatory network" was constructed using Cytoscape software and PERL programming language.

Tuning the Selectivity of Liquid Products of CORR by Cu-Ag Alloying.

The combination of Cu and Ag presents a promising way to steer the CO reduction products through regulating the surface active sites. However, the difficulty in forming the CuAg alloy with a controllable atomic ratio impedes the in-depth understanding of the structure-activity relationship of CuAg catalysts. Herein, we use E-beam evaporation to synthesize a series of CuAg films with uniform distribution and controllable stoichiometry to reveal the real reaction mechanism on CuAg for the electrochemical CO reduction process.

In Situ Construction of Flexible VNi Redox Centers over Ni-Based MOF Nanosheet Arrays for Electrochemical Water Oxidation.

Atomic-level design and construction of synergistic active centers are central to develop advanced oxygen electrocatalysts toward efficient energy conversion. Herein, an in situ construction strategy to introduce flexible redox sites of VNi centers onto Ni-based metal-organic framework (MOF) nanosheet arrays (NiV-MOF NAs) as a promising oxygen electrocatalyst is developed. The abundant redox VNi centers with flexible metal valence states of V and Ni enable NiV-MOF NAs excellent oxygen evolution reaction (OER) activity and a long-term stability under high current densities, achieving current densities of 10 and 100 mA cm at recorded overpotentials of 189 and 290 mV, respectively, and showing ignorable decay of initial activity at 100 mA cm after 100 h OER operation.

Dynamic CoRu Bond Shrinkage at Atomically Dispersed Ru Sites for Alkaline Hydrogen Evolution Reaction.

Accurately manipulating the electronic structure of metal active sites under working conditions is central to developing efficient and stable electrocatalysts in industrial water-alkali electrolyzers. However, the lack of an intuitive means to capture the evolution of metal sites during the reaction state inhibits the manipulation of its electronic structure. Here, atomically dispersed Ru single-sites on cobalt nanoparticles confined onto macro-microporous frameworks (M-Co NPs@Ru SAs/NC) with tunable electron coupling effect for efficient catalysis of alkaline hydrogen evolution reaction (HER) are constructed.

In-situ spectroscopic observation of dynamic-coupling oxygen on atomically dispersed iridium electrocatalyst for acidic water oxidation.

Uncovering the dynamics of active sites in the working conditions is crucial to realizing increased activity, enhanced stability and reduced cost of oxygen evolution reaction (OER) electrocatalysts in proton exchange membrane electrolytes. Herein, we identify at the atomic level potential-driven dynamic-coupling oxygen on atomically dispersed hetero-nitrogen-configured Ir sites (AD-HN-Ir) in the OER working conditions to successfully provide the atomically dispersed Ir electrocatalyst with ultrahigh electrochemical acidic OER activity. Using in-situ synchrotron radiation infrared and X-ray absorption spectroscopies, we directly observe that one oxygen atom is formed at the Ir active site with an O-hetero-Ir-N structure as a more electrophilic active centre in the experiment, which effectively promotes the generation of key *OOH intermediates under working potentials; this process is favourable for the dissociation of HO over Ir active sites and resistance to over-oxidation and dissolution of the active sites.

Self-Nanocavity-Confined Halogen Anions Boosting the High Selectivity of the Two-Electron Oxygen Reduction Pathway over Ni-Based MOFs.

We present a strategy of self-nanocavity confinement for substantially boosting the superior electrochemical hydrogen peroxide (HO) selectivity for conductive metal-organic framework (MOF) materials. By using synchrotron radiation X-ray adsorption fine structure and Fourier transform infrared spectroscopy analyses, the dissociation of key *OOH intermediates during the oxygen reduction reaction (ORR) is effectively suppressed over the self-nanocavity-confined X-Ni MOF (X = F, Cl, Br, or I) catalysts, contributing to a favorable two-electron ORR pathway for highly efficient HO production. As a result, the as-prepared Br-confined Ni MOF catalyst significantly promotes HO selectivity up to 90% in an alkaline solution, evidently outperforming the pristine Ni MOF catalyst (40%).

Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2.

Long non-coding RNAs are a kind of endogenous ncRNAs with a length of more than 200 bp. Accumulating evidence suggests that long non-coding RNAs function as pivotal regulators in tumorigenesis and progression. However, their biological roles in breast cancer remain largely unknown.

Down-regulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR-455-5p.

Background: As a type of head and neck squamous cell carcinoma (HNSCC), oral squamous cell carcinoma (OSCC) has a high incidence and low survival rate. Frequent deletion of protein tyrosine phosphatase receptor type sigma (PTPRS) has been found in HNSCC. Long non-coding RNA (lncRNA) HCG11 and miR-455-5p have been reported to be involved in several cancers, in which miR-455-5p was found to be up-regulated in the OSCC.

MOVES-Matrix for high-performance on-road energy and running emission rate modeling applications.

The MOVES model was developed by the U.S. Environmental Protection Agency (U.

Auditory temporal perceptual learning and transfer in Chinese-speaking children with developmental dyslexia.

Perceptual learning refers to the improvement of perceptual performance as a function of training. Recent studies found that auditory perceptual learning may improve phonological skills in individuals with developmental dyslexia in alphabetic writing system. However, whether auditory perceptual learning could also benefit the reading skills of those learning the Chinese logographic writing system is, as yet, unknown.

Safety impacts of bicycle infrastructure: A critical review.

Problem And Method: This paper takes a critical look at the present state of bicycle infrastructure treatment safety research, highlighting data needs. Safety literature relating to 22 bicycle treatments is examined, including findings, study methodologies, and data sources used in the studies. Some preliminary conclusions related to research efficacy are drawn from the available data and findings in the research.

Understanding the emission impacts of high-occupancy vehicle (HOV) to high-occupancy toll (HOT) lane conversions: Experience from Atlanta, Georgia.

Unlabelled: Converting a congested high-occupancy vehicle (HOV) lane into a high-occupancy toll (HOT) lane is a viable option for improving travel time reliability for carpools and buses that use the managed lane. However, the emission impacts of HOV-to-HOT conversions are not well understood. The lack of emission impact quantification for HOT conversions creates a policy challenge for agencies making transportation funding choices.

MOVES-Matrix and distributed computing for microscale line source dispersion analysis.

Unlabelled: MOVES and AERMOD are the U.S. Environmental Protection Agency's recommended models for use in project-level transportation conformity and hot-spot analysis.

Water-soluble thermoresponsive α-helical polypeptide with an upper critical solution temperature: synthesis, characterization, and thermoresponsive phase transition behaviors.

Water-soluble polypeptides bearing 1-alkylimidazolium (methyl or n-butyl) and various counter-anions (i.e., Cl(-), I(-) or BF4 (-)) are prepared by ring-opening polymerization of γ-4-chloromethylbenzyl-l-glutamate-based N-carboxyanhydride (3), post-polymerization of poly(γ-4-chloromethylbenzyl-l-glutamate) (4), and ion-exchange reaction.

The behavioral economics of drunk driving.

This study investigates whether drinker-drivers attributes are associated with imperfect rationality or irrationality. Using data from eight U.S.

Are People Overoptimistic about the Effects of Heavy Drinking?

We test whether heavy or binge drinkers are overly optimistic about probabilities of adverse consequences from these activities or are relatively accurate about these probabilities. Using data from a survey in eight cities, we evaluate the relationship between subjective beliefs and drinking. We assess accuracy of beliefs about several outcomes of heavy/binge drinking: reduced longevity, liver disease onset, link between alcohol consumption and Driving While Intoxicated (DWI), probability of an accident after drinking, accuracy of beliefs about encountering intoxicated drivers on the road, and legal consequences of DWI-ranging from being stopped to receiving fines and jail terms.

[Effect of shuanghuangbu on the adhesion growth and proliferation of human periodontal ligament cells on the zein stent].

Objective: To study the effect of Shuanghuangbu on the adhesion growth and proliferation of human periodontal ligament cells (HPDLCs) on the zein scaffold, and to study the feasibility of Shuanghuangbu zein used in the periodontal tissue engineering as a compound scaffold material.

Methods: HPDLCs were cultured in vitro using the explants adherent method. Shuanghuangbu Decoction was prepared using water extraction and alcohol precipitation method.

The use of zein and Shuanghuangbu for periodontal tissue engineering.

Aim: Tissue engineering is a promising area with a broad range of applications in the fields of regenerative medicine and human health. The emergence of periodontal tissue engineering for clinical treatment of periodontal disease has opened a new therapeutic avenue. The choice of scaffold is crucial.