Solubility and Pharmacokinetic Profile Improvement of Griseofulvin through Supercritical Carbon Dioxide-Assisted Complexation with HP--Cyclodextrin.

Since griseofulvin was marketed as a non-polyene antifungal antibiotic drug in 1958, its poor water solubility has been an issue for its wide applications, and over the last sixty years, many attempts have been made to increase its water solubility; however, a significant result has yet to be achieved. Through supercritical carbon dioxide-assisted cyclodextrin complexation with the addition of a trace amount of water-soluble polymer surfactant, the griseofulvin inclusion complex with HP--cyclodextrin was prepared and confirmed. The 1:2 ratio of griseofulvin and HP--cyclodextrin in the complex was determined based on its NMR study.

Factors influencing the length of stay after mediastinal tumor resection in the setting of an enhanced recovery after surgery (ERAS)-TUBELESS protocol.

Background: Prolonged length of stay after surgery is considered to increase cost and hospital-acquired complications. Therefore, we aimed to identify the risk factors that were associated with an increased length of stay after mediastinal tumor resection in the setting of an enhanced recovery after surgery (ERAS)-TUBELESS protocol.

Methods: This prospective cohort study collected data on consecutive patients undergoing video-assisted thoracoscopic surgery (VATS) resection for mediastinal tumor between December 2015 and November 2018 at a single center in China.

Single- versus two-port video-assisted thoracic surgery in mediastinal tumor: a propensity-matched study.

Background: In this retrospective study, we aimed to compare single-port (SP) and two-port (TP) video-assisted thoracic surgery (VATS) for the surgical resection of mediastinal tumor.

Methods: Between December 2015 and October 2018, a total of 191 consecutive mediastinal tumor patients who underwent SP- or TP-VATS in the First Affiliated Hospital of Guangzhou Medical University were enrolled. Propensity-matched analysis, incorporating preoperative clinical features, was used to compare the perioperative outcomes and analyse the safety and efficacy between SP-VATS and TP-VATS for mediastinal tumor.

[Identification of cellular morphology and flow cytometry on different tetraploid Isatis indigotica strains].

Objective: To identify tetraploid Isatis indigotica strains through morphology and flow cytometry.

Methods: The tissue culture seedlings of tetraploid Isatis indigotica were root-tip squashed and chromosome counted before rooted climatized and transplanted in field. The plants in field were taken as experimental materials.

[Effects of PEG and NaCl stress on the contents of indigotin and indirubin in Isatis indigotica tetraploids].

Objective: To provide a reference evidence for choosing salt-resistent and drought-resistent varieties of Isatis indigotica Fort..

Methods: The tissue culture seedlings of different Isatis indigotica tetraploids were used as plant materials.

Three-photon absorption and nonlinear refraction of BaMgF4 in the ultraviolet region.

The nonlinear refraction and nonlinear absorption phenomena are investigated in BaMgF(4) single crystal using the Z-scan technique in the ultraviolet region with a pulsed laser at 400 nm with 1 ps pulse duration. The remarkable nonlinear absorption behavior is identified to be three-photon absorption under the experimental conditions. In addition, both nonlinear refraction and nonlinear absorption have relatively large values and possess small anisotropy along three different crystallographic axes.