Promoting Proton Donation through Hydrogen Bond Breaking on Carbon Nitride for Enhanced HO Photosynthesis.

Photocatalytic HO production has attracted much attention as an alternative way to the industrial anthraquinone oxidation process but is limited by the weak interaction between the catalysts and reactants as well as inefficient proton transfer. Herein, we report on a hydrogen-bond-broken strategy in carbon nitride for the enhancement of HO photosynthesis without any sacrificial agent. The HO photosynthesis is promoted by the hydrogen bond formation between the exposed N atoms on hydrogen-bond-broken carbon nitride and HO molecules, which enhances proton-coupled electron transfer and therefore the photocatalytic activity.

Efficacy, Safety, and Population Pharmacokinetics of MW032 Compared With Denosumab for Solid Tumor-Related Bone Metastases: A Randomized, Double-Blind, Phase 3 Equivalence Trial.

Importance: The bioequivalence of denosumab biosimilar has yet to be studied in a 53-week, multicenter, large-scale, and head-to-head trial. A clinically effective biosimilar may help increase access to denosumab in patients with solid tumor-related bone metastases.

Objectives: To establish the biosimilarity of MW032 to denosumab in patients with solid tumor-related bone metastases based on a large-scale head-to-head study.

Central nervous system efficacy of rezivertinib (BPI-7711) in advanced NSCLC patients with EGFR T790M mutation: A pooled analysis of two clinical studies.

Background: Rezivertinib (BPI-7711) is a novel third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) which revealed the systematic and central nervous system (CNS) antitumor activities for EGFR T790M-mutated advanced NSCLC in previous clinical studies and is further analyzed here.

Methods: Eligible patients from the previous phase I and phase IIb studies of rezivertinib were included for pooled analysis. Post-progressive patients who received a prescribed dosage (≥180 mg) of rezivertinib orally once daily were included in full analysis set (FAS), while those with stable, asymptomatic CNS lesions, including measurable and non-measurable ones at baseline were included in CNS full analysis set (cFAS).

Apatinib in the treatment of gastric cancer in Henan Province: a multicenter prospective real-world observational study (Ahead-HAP01).

Background: Apatinib is approved in China for the treatment of advanced gastric adenocarcinoma that had progressed or relapsed after standard systemic chemotherapy treatments. However, the effectiveness of Apatinib under real-world condition has not been evaluated and the drug performance under ideal and controlled circumstances has not been validated. In fact, genetic factors, poor healthcare access, social economic status, comorbidities compliance and other factors play significant role in drug performance under "real-world" conditions.

Tipping Gold Nanobipyramids with Titania for the Use of Plasmonic Hotspots to Drive Amine Coupling.

Designing plasmonic photocatalysts with spatially controlled catalytic sites is an effective strategy to boost the sunlight-driven chemical transformation efficiency through plasmonic enhancement. Herein, we describe a facile method for the synthesis of TiO-tipped Au nanobipyramids (NBPs) to give (Au NBP)/t-TiO nanodumbbells. The surfactant cetyltrimethylammonium bromide concentration is the key factor in the construction of this type of unique nanostructure.

Efficacy and Safety of Rezivertinib (BPI-7711) in Patients With Locally Advanced or Metastatic/Recurrent EGFR T790M-Mutated NSCLC: A Phase 2b Study.

Introduction: Rezivertinib (BPI-7711) is a novel third-generation EGFR tyrosine kinase inhibitor (TKI) targeting both EGFR-sensitizing mutations and EGFR T790M mutation. This study aimed to evaluate the efficacy and safety of rezivertinib in patients with locally advanced or metastatic/recurrent EGFR T790M-mutated NSCLC.

Methods: Patients with locally advanced or metastatic/recurrent NSCLC with confirmed EGFR T790M mutation who progressed after first-/second-generation EGFR TKI therapy or primary EGFR T790M mutation were enrolled.

Efficacy and Safety of a Pegasparaginase-Based Chemotherapy Regimen vs an L-asparaginase-Based Chemotherapy Regimen for Newly Diagnosed Advanced Extranodal Natural Killer/T-Cell Lymphoma: A Randomized Clinical Trial.

Importance: The L-asparaginase-based SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) chemotherapy regimen has shown higher response rates and survival benefit over an anthracycline-containing regimen. However, the safety profile was not satisfied. A well-tolerated regimen with promising efficacy is lacking.

Growth of narrow-bandgap Cl-doped carbon nitride nanofibers on carbon nitride nanosheets for high-efficiency photocatalytic HO generation.

Heterojunction construction has been proved to be an effective way to enhance photocatalysis performance. In this work, Cl-doped carbon nitride nanofibers (Cl-CNF) with broadband light harvesting capacity were grown on carbon nitride nanosheets (CNS) by a facile hydrothermal method to construct a type II heterojunction. Benefiting from the joint effect of the improved charge carriers separation efficiency and a broadened visible light absorption range, the optimal heterostructure of Cl-CNF/CNS exhibits a HO evolution rate of 247.

Camrelizumab plus apatinib as second-line treatment for advanced oesophageal squamous cell carcinoma (CAP 02): a single-arm, open-label, phase 2 trial.

Background: Camrelizumab, an anti-PD-1 antibody, has shown moderate efficacy in oesophageal squamous cell carcinoma. Apatinib, a selective inhibitor of VEGFR2, has a synergistic effect with immunotherapy. We aimed to assess the combination of camrelizumab and apatinib as second-line treatment for advanced oesophageal squamous cell carcinoma.

Bioinspired Synthesis of ZnO@polydopamine/Au for Label-Free Photoelectrochemical Immunoassay of Amyloid-β Protein.

Amyloid-β protein (Aβ) is an important biomarker and plays a key role in the early stage of Alzheimer's disease (AD). Here, an ultrasensitive photoelectrochemical (PEC) sensor based on ZnO@polydopamine/Au nanocomposites was constructed for quantitative detection of Aβ. In this sensing system, the ZnO nanorod array decorated with PDA films and gold nanoparticles (Au NPs) have excellent visible-light activity.

Plasmon-enabled N photofixation on partially reduced TiC MXene.

Benefiting from the superior conductivity, rich surface chemistry and tunable bandgap, TiC MXene has become a frontier cocatalyst material for boosting the efficiency of semiconductor photocatalysts. It has been theoretically predicted to be an ideal material for N fixation. However, the realization of N photofixation with TiC as a host photocatalyst has so far remained experimentally challenging.

A novel deposition mechanism of Au on Ag nanostructures involving galvanic replacement and reduction reactions.

Combining a galvanic replacement reaction with a reduction reaction can provide more possibility in the synthesis of Au-Ag hollow nanostructures. However, the detailed atomic deposition mechanism involving these two reactions is unclear. Herein, we proposed a novel deposition mechanism of the Au atoms on Ag nanostructures involving simultaneous galvanic replacement and reduction reactions.

Selective Deposition of Catalytic Metals on Plasmonic Au Nanocups for Room-Light-Active Photooxidation of -Phenylenediamine.

Plasmonic hotspots can enhance hot charge carrier generation, offering new opportunities for improving the photocatalytic activity. In this work, eight types of heteronanostructures are synthesized by selectively depositing catalytic metals at the different sites of highly asymmetric Au nanocups for the photocatalytic oxidation of -phenylenediamine. The oxidation of this molecule has so far mainly relied on the use of HO as an oxidizing agent in the presence of an appropriate catalyst.

Metal-free g-CN nanosheets as a highly visible-light-active photocatalyst for thiol-ene reactions.

Thiol-ene click reactions are important for the construction of carbon-sulfur bonds. The use of visible-light photoredox catalysis for the formation of C-S bonds has attracted much attention. In this work, two-dimensional metal-free graphitic carbon nitride (g-CN) nanosheets are prepared through a simple thermal polymerization method and used to catalyze the thiol-ene click reaction under visible light-illumination.

Photodriven Disproportionation of Nitrogen and Its Change to Reductive Nitrogen Photofixation.

Nitrogen fixation is an essential process for sustaining life. Tremendous efforts have been made on the photodriven fixation of nitrogen into ammonia. However, the disproportionation of dinitrogen to ammonia and nitrate under ambient conditions has remained a grand challenge.

Gold nanobipyramid-embedded ultrathin metal nanoframes for monitoring catalytic reactions.

Metal nanoframes, especially ultrathin ones, with excellent plasmonic properties are synthetically interesting and highly attractive. Herein we report on the synthesis of Au nanobipyramid-embedded ultrathin metal nanoframes with one of the plasmon modes very similar to that of the Au nanobipyramids. The synthesis is mediated by silver coating on Au nanobipyramids.

A Z-scheme photocatalyst for enhanced photocatalytic H evolution, constructed by growth of 2D plasmonic MoO nanoplates onto 2D g-CN nanosheets.

Light-harvesting capacity and photoexcited charge carrier separation ability are two crucial requirements for high-efficiency semiconductor photocatalysis. Here, we report a plasmonic Z-scheme nanohybrid by hydrothermally in-situ growing two-dimensional (2D) oxygen-deficient molybdenum oxide (MoO) nanoplates onto 2D graphitic carbon nitride (g-CN) nanosheets. The resultant 2D/2D MoO/g-CN nanohybrids not only construct a unique Z-scheme heterojunction, which improves the photogenerated charge carrier separation efficiency, but also possess numerous oxygen vacancies on the surface of MoO, which could excite its plasmon resonance for extending spectrum adsorption.

MicroRNA-96-5p represses breast cancer proliferation and invasion through Wnt/β-catenin signaling via targeting CTNND1.

Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells.

Pancreatic fistula after pancreaticoduodenectomy: Risk factors and preventive strategies.

Purpose: Postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) is a worrisome and life-threatening complication. This study aimed to investigate the risk factors and preventive strategies for POPF after PD.

Materials And Methods: We retrospectively reviewed 301 consecutive patients who underwent PD at our hospitals between January 2011 and December 2017.

Colloidal porous gold nanoparticles.

Porous Au nanostructures have attracted much attention for their wide uses as catalysts, sensors, actuators and surface-enhanced Raman scattering (SERS) substrates. The synthesis of porous Au nanostructures has mainly relied on dealloying approaches, which generally involve high-temperature treatment to form alloys and subsequent harsh chemical etching. Herein we report on an ambient wet-chemistry method for the synthesis of colloidal porous Au nanoparticles.

Understanding the roles of plasmonic Au nanocrystal size, shape, aspect ratio and loading amount in Au/g-CN hybrid nanostructures for photocatalytic hydrogen generation.

Hybrid photocatalysts containing plasmonic metal and semiconductor building blocks can alleviate charge carrier recombination and broaden the range of light absorption of the semiconductor. In this work, plasmonic Au nanocrystals of different sizes and shapes (spheres and rods) are attached on graphitic carbon nitride (g-C3N4) nanosheets through electrostatic attraction. The effects of the morphology and loading amount of the Au nanocrystals are carefully studied for understanding and optimizing the hybrid photocatalysts.