Dural metastases in breast cancer: progression pattern, treatment and prognosis-a single center experience.

Background: Dural metastasis (DM) remains one of the most challenging clinical scenarios in breast cancer treatment. To date, no clear standard care of dural metastases has been established. We sought to identify the progression pattern or treatment strategies that could possibly improve prognosis of breast cancer patients with DM.

Removal of hypertoxic Cr(VI) from water by polyaniline-coated ZIF-67-derived nitrogen-doped magnetic carbon.

Heavy metals are highly toxic and nonbiodegradable, posing a serious threat to the water environment and human beings. Therefore, it is crucial to develop a highly efficient adsorbent that is easy to recover and separate for the removal of heavy metals. In this paper, nitrogen-doped magnetic carbon (NC-67) was prepared by carbonization and hydrochloric acid treatment using cobalt-containing MOF (ZIF-67) as precursor.

Dual-mode fluorescence and colorimetric smartphone-based sensing platform with oxidation-induced self-assembled nanoflowers for sarcosine detection.

Background: Early prostatic cancer (PCa) diagnosis significantly improves the chances of successful treatment and enhances patient survival rates. Traditional enzyme cascade-based early cancer detection methods offer efficiency and signal amplification but are limited by cost, complexity, and enzyme dependency, affecting stability and practicality. Meanwhile, sarcosine (Sar) is commonly considered a biomarker for PCa development.

Mechanically Tunable Circularly Polarized Luminescence of Liquid Crystal-Templated Chiral Perovskite Quantum Dots.

Endowing perovskite quantum dots (PQDs) with circularly polarized luminescence (CPL) offers great promise for innovative chiroptical applications, but the existing strategies are inefficient in acquiring stimuli-responsive flexible chiral perovskite films with large, tunable dissymmetry factor (g) and long-term stability. Here, we report a strategy for the design and synthesis of luminescent cholesteric liquid crystal elastomer (Lumin-CLCE) films with mechanically tunable CPL, which is enabled by liquid crystal-templated chiral self-assembly and in situ covalent cross-linking of judiciously designed photopolymerizable CsPbX (X=Cl, Br, I) PQD nanomonomers into the elastic polymer networks. The resulting Lumin-CLCE films showcase circularly polarized structural color in natural light and noticeable CPL with a maximum g value of up to 1.

Closed-loop process for selective leaching and recovery of palladium from spent auto-exhaust catalysts using iodotrihalide ionic liquids.

The recovery of palladium from spent auto-exhaust catalysts (SAE-catalysts) is of great significance for resource sustainability. Herein, we proposed an efficient closed-loop leaching and recovery method for palladium from SAE-catalysts using iodotrihalide ionic liquids (ILs). Recovery design was explored aimed at green leaching and process simplification.

Ceria-Based Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing.

In recent years, there has been a notable increase in interest surrounding nanozymes due to their ability to imitate the functions and address the limitations of natural enzymes. The scientific community has been greatly intrigued by the study of nanoceria, primarily because of their distinctive physicochemical characteristics, which include a variety of enzyme-like activities, affordability, exceptional stability, and the ability to easily modify their surfaces. Consequently, nanoceria have found extensive use in various biosensing applications.

Mechanochromic and ionic conductive cholesteric liquid crystal elastomers for biomechanical monitoring and human-machine interaction.

Cholesteric liquid crystal elastomers (CLCEs) that combine rubbery elasticity with structural colour from self-assembled helical nanostructures are of paramount importance for diverse applications such as biomimetic skins, adaptive optics and soft robotics. Despite great advances, it is challenging to integrate electrical sensing and colour-changing characteristics in a single CLCE system. Here, we report the design and synthesis of an ionic conductive cholesteric liquid crystal elastomer (iCLCE) through Michael addition and free-radical photopolymerization of CLCE precursors on silane-functionalized polymer ionic liquid networks, in which robust covalent chemical bonding was formed at the interface.

Leveraging brassinosteroids towards the next Green Revolution.

The use of gibberellin-related dwarfing genes significantly increased grain yield during the Green Revolution. Brassinosteroids (BRs) play a vital role in regulating agronomic traits and stress resistance. The potential of BR-related genes in crop improvement has been well demonstrated, positioning BRs as crucial targets for the next agricultural biotechnological revolution.

High nitrogen content bimolecular co-functionalized graphene nanoflakes for hypertoxic Cr(VI) removal: Insights into adsorption behavior and mechanisms.

The proven high carcinogenicity to humans and high destructive force to the environment determine the extreme urgency of eliminating hypertoxic Cr(VI) in water bodies. Herein, a route of room temperature synthesis and secondary grafting was proposed to fabricate graphene oxide-based nanoadsorbent co-functionalized with polydopamine and branched polyethyleneimine (GOPP) to remove Cr(VI). The flexible decoration of polydopamine and polyethyleneimine on GO flakes could gradually enhance the amount of N-containing functional groups and realize selective removal of Cr(VI) with the maximum experimental adsorption capacity of 564.

Three-dimensional magnetic resonance elastography combining proton-density fat fraction precisely identifies metabolic dysfunction-associated steatohepatitis with significant fibrosis.

Purpose: Patients with metabolic dysfunction-associated steatohepatitis (MASH) and significant fibrosis (fibrosis stage≥2), known as Fibro-MASH, are at increased risk of liver-related outcomes and lower rates of spontaneous disease regression. The aim was to investigate three-dimensional MR elastography (3D-MRE) combining proton-density fat fraction (PDFF) as a means of identifying Fibro-MASH.

Methods: Forty-eight New Zealand rabbits were fed a high-fat/cholesterol or standard diet to obtain different disease activity and fibrosis stages.

Hollow porphyrin-based porous organic polymer with dual enzyme-like activities for ultra-fast colorimetric detection of Cr (VI) in wastewater.

A hollow porphyrin-based porous organic polymer (H-Fe-POP) was prepared for rapid and sensitive colorimetric determination of Cr(VI), which exhibited excellent dual enzyme-like activities, including oxidase-like and peroxidase-like activities. Due to the specific binding of 8-hydroxyquinoline (8-HQ) to Cr(VI), 3,3',5,5'-tetramethylbenzidine (TMB) was liberated, and TMB was oxidized to blue ox-TMB catalyzed by H-Fe-POP. Based on the excellent oxidase-like activity of H-Fe-POP, an ultra-fast colorimetric platform for the detection of Cr(VI) was constructed, allowing the quantification of Cr(VI) in the range 2-130 μM within 30 s with a detection limit of 0.

Mechanochromic and Conductive Chiral Nematic Nanostructured Film for Bioinspired Ionic Skins.

Chameleon skin is naturally adaptive and can sense environmental changes and transform sensing into bioelectrical and optical signals by manipulating ion transduction and photonic nanostructures. The increasing interest in mimicking biological skins has considerably promoted the development of advanced photonic materials with an increasing ionic conductivity. Herein, we report the judicious design and fabrication of a bioinspired mechanochromic chiral nematic nanostructured film with good ionic conductivity by infiltrating fluorine-rich ionic liquids (FILs) into a swollen self-assembled cellulose nanocrystal (CNC) film with helical nanoarchitectures.

Flow diagram of the differential diagnosis and clinical decision making in a rare case of contrast-induced encephalopathy following cardiac catheterization: a case report.

Background: Contrast-induced encephalopathy (CIE) is considered as an uncommon complication following cardiac catheterization. Due to the varied manifestations, CIE has no formal diagnostic criteria. In fact, the incidence of CIE may be greatly underestimated because of the difficulty in its differential diagnosis with other cerebrovascular complications.

Spatiotemporal Characteristics of Food Supply-Demand Balance in Uzbekistan under Different Scenarios.

The food supply-demand balance is a perpetual concern for many countries, especially developing countries, such as Uzbekistan. Using the land resource carrying capacity model, here, food supply and demand for the cereals and calories in Uzbekistan during 1995-2020 were revealed. Despite increased demand for cereals and calories, unstable crop production has led to volatile growth patterns.

Wireless Power Transfer to Electrothermal Liquid Crystal Elastomer Actuators.

Wireless actuation of electrically driven soft actuators is of paramount importance for the development of bioinspired soft robotics without physical connection or on-board batteries. Here, we demonstrate untethered electrothermal liquid crystal elastomer (LCE) actuators based on emerging wireless power transfer (WPT) technology. We first design and fabricate electrothermal LCE-based soft actuators that consist of an active LCE layer, a conductive liquid metal-filled polyacrylic acid (LM-PA) layer, and a passive polyimide layer.

First principles terahertz spectroscopy of molecular crystals: the crucial role of periodic boundary conditions benchmarked with experimental L-ascorbic acid spectra.

The terahertz (THz) region vibration spectral signatures of molecular crystals can usually be ascribed to the low-frequency vibrational modes related to weak intermolecular interactions, van der Waals (vdW) interactions or hydrogen bonding. These interactions collectively dictate the compositional units deviating from their equilibrium configurations. The collective movements are intrinsically long-range, and hence the boundary conditions used for theoretical calculation can affect the corresponding potential energy gradients and alter the vibrational features.

Coupling of Oxygen Vacancies and Heterostructure on Fe O via an Anion Doping Strategy to Boost Catalytic Activity for Lithium-Sulfur Batteries.

The sluggish reaction kinetics and severe shutting behaviors of sulfur cathodes are the major roadblocks to realizing the practical application of lithium-sulfur (Li-S) batteries and need to be solved through designing/constructing rational sulfur hosts. Herein, an effective alternative material of Fe O /FeP in-situ embedded in N-doped carbon-tube (Fe O /FeP/NCT) is proposed. In this fabricated heterostructure, NCT skeleton works as a sulfur host provides physical barrier for lithium polysulfides (LiPSs), while Fe O /FeP heterostructure with abundant oxygen vacancies provides double active centers to simultaneously accelerate e /Li diffusion/transport kinetics and catalysis for LiPSs.

Does Nepal Have the Agriculture to Feed Its Population with a Sustainable Diet? Evidence from the Perspective of Human-Land Relationship.

Nepal is one of the least developed countries in the world, with more than 80% of the population engaged in agricultural production and more than two-fifths of the population still living below the poverty line. Ensuring food security has always been a key national policy in Nepal. Using a nutrient conversion model and an improved resource carrying capacity model as well as statistical data and household questionnaires, an analysis framework for food supply balance is developed in this study, which quantitatively analyzes the balance of food supply and demand in Nepal from the perspectives of food and calories during the period 2000-2020.

Diagnostic performance of deep learning-based vessel extraction and stenosis detection on coronary computed tomography angiography for coronary artery disease: a multi-reader multi-case study.

Background: Post-processing and interpretation of coronary CT angiography (CCTA) imaging are time-consuming and dependent on the reader's experience. An automated deep learning (DL)-based imaging reconstruction and diagnosis system was developed to improve diagnostic accuracy and efficiency.

Methods: Our study including 374 cases from five sites, inviting 12 radiologists, assessed the DL-based system in diagnosing obstructive coronary disease with regard to diagnostic performance, imaging post-processing and reporting time of radiologists, with invasive coronary angiography as a standard reference.

Pattern changes of ecological product trade in countries along the Belt and Road.

The Belt and Road Initiative (BRI) was designed to promote economic and trade cooperation between countries along the Belt and Road (B&R), specifically by building an international trade network. Ecological resources are the basis for human survival. Countries along the B&R transform ecological resources into ecological products by production activities.

The U-box ubiquitin ligase TUD1 promotes brassinosteroid-induced GSK2 degradation in rice.

Brassinosteroids (BRs) are a class of steroid hormones with great potential for use in crop improvement. De-repression is usually one of the key events in hormone signaling. However, how the stability of GSK2, the central negative regulator of BR signaling in rice (Oryza sativa), is regulated by BRs remains elusive.

Three-Dimensional Electrochromic Soft Photonic Crystals Based on MXene-Integrated Blue Phase Liquid Crystals for Bioinspired Visible and Infrared Camouflage.

Developing bioinspired camouflage materials that can adaptively change color in the visible and infrared (IR) regions is an intriguing but challenging task. Herein, we report an emerging strategy for fabricating dynamic visible and IR camouflage materials by the controlled in situ growth of novel photopolymerizable blue phase liquid crystals with cubic nanoarchitectures onto highly aligned MXene nanostructured thin films. The resulting MXene-integrated 3D soft photonic crystals exhibit vivid structural colors and reversible switching between a bright colored state and a dark black state under a low DC electric field.