Evaluation of systemic medications associated with diabetic retinopathy: a nested case-control study from the UK Biobank.

Aims: This study aims to investigate the associations between commonly used systemic medications and diabetic retinopathy (DR).

Methods: Individuals with linked primary care prescription data from the UK Biobank were included. Cases were defined as individuals with a Hospital Episode Statistics-coded or primary care recorded diagnosis of DR or self-reported DR.

Hotspots and frontiers of genetic research on pediatric cataracts from 2013 to 2022: a scientometric analysis.

Aim: To explore the hotspots and frontiers of genetic research on pediatric cataracts.

Methods: Global publications from 2013 to 2022 related to genes in pediatric cataracts were extracted from the Web of Science Core Collection, and were analyzed in terms of the publication counts, countries, journals, authors, keywords, cited references, subject categories, and the underlying hotspots and frontiers.

Results: Totally 699 publications were included in the final analysis.

Evolution and trends of childhood cataract research in the past 10 years: A scientometric analysis.

Purpose: To present a panoramic review of childhood cataract knowledge networks, hotspots and trends.

Methods: The Web of Science Core Collection was used to retrieve the global literature on childhood cataract published between 2012 and 2021. Scientometric data were analyzed and visualized using VOSviewer and CiteSpace for metrics including publication count, citation count, country, journal, author, cited reference, subject category and their temporal trends.

The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors.

Background: To investigate the prevalence and related influencing factors of subclinical hypothyroidism (SCH) in a pre-diabetes (PreDM) population.

Patients And Methods: A multi-stage stratified cluster random sampling method was used to select the adult Han population in Gansu Province for investigation. General data and related biochemical indices were recorded and SPSS software was used for statistical analyses.

Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis.

Osteoarthritis (OA) is one of the most common chronic joint diseases and is gradually becoming the main cause of disability and joint pain in the elderly worldwide. Pyroptosis is a regulated programmed cell death triggered by inflammasomes. It leads to cell swelling, lysis, and bioactive molecule secretion.

Treatment Effect of Long-Term Antipsychotics on Default-Mode Network Dysfunction in Drug-Naïve Patients With First-Episode Schizophrenia: A Longitudinal Study.

The maintenance of antipsychotic treatment is an efficient way to prevent the relapse of schizophrenia (SCZ). Previous studies have identified beneficial effects of antipsychotics on brain structural and functional abnormalities during mostly the acute phase in SCZ, but seldom is known about the effects of long-term antipsychotics on the brain. The present study focused on the long-term antipsychotic effect on the default mode network (DMN) dysfunction in SCZ.

Introduction of an interface layer on hydroxyapatite whisker/poly(L-lactide) composite and its contribution for improved bioactivity and mechanical properties.

A hydroxyapatite whisker (w-HA) was synthesized via dissolution-precipitation by forming calcium-ethylene diamine tetra acetic acid (Ca-EDTA) complexing. The hydroxyapatite whisker was formed with precipitation of Ca along the c-axis due to the space inhibition of Ca-EDTA complex during refluxing. The op-w-HA (oligomeric poly(lactic acid) modified w-HA), p-w-HA (poly(L-lactide) modified w-HA) and pc-w-HA (poly(L-lactide) and cyclodextrin modified w-HA) were obtained via the surface modification of w-HA.

Association between serum β2-microglobulin levels and frailty in an elderly Chinese population: results from RuLAS.

Objective: To examine the association between serum β2-microglobulin (B2M) levels and frailty in an elderly Chinese population.

Design: A population-based cohort study.

Setting And Participants: We used data on 1,663 elderly participants (aged 70-84 years) from the aging arm of the Rugao Longevity and Ageing study, a population-based observational two-arm cohort study conducted in Rugao, China.

Modified Hyperbranched Polyglycerol as Dispersant for Size Control and Stabilization of Gold Nanoparticles in Hydrocarbons.

Hyperbranched polyglycerol (HPG) is modified with dodecanethiol (DS) via the "thiol-ene" click reaction to obtain an amphiphilic product DSHPG. The molecular structures of DSHPG samples are characterized by NMR, FTIR, and GPC, and the thermal behaviors are characterized by DSC and TGA. Gold nanoparticles (Au NPs) are prepared with DSHPG as the stabilizer and surface-modification reagent.