Publications by authors named "Yanyi Wu"
Unveiling the black box: imperative for explainable AI in cardiovascular disease prevention.
Lancet Reg Health West Pac
July 2024
The development of new antibiotics continues to pose challenges, particularly considering the growing threat of multidrug-resistant Staphylococcus aureus. Structurally diverse natural products provide a promising source of antibiotics. Herein, we outline a concise approach for the collective asymmetric total synthesis of polycyclic xanthene myrtucommulone D and five related congeners.
View Article and Find Full Text PDFDiscovery of a novel, liver-targeted thyroid hormone receptor-β agonist, CS271011, in the treatment of lipid metabolism disorders.
Front Endocrinol (Lausanne)
February 2023
Article Synopsis
- Thyroid hormone receptor β (THR-β) is essential for regulating metabolism, and this study evaluated a new THR-β agonist called CS271011 for its safety and efficiency in comparison to another drug, MGL-3196.
- The methodology included various tests on mice with a high-fat diet, focusing on body weight, liver functions, and gene expression related to lipid metabolism after administering CS271011 and MGL-3196.
- Results indicated that CS271011 had superior activation of THR-β, better pharmacokinetics, and effectively improved fat metabolism and liver health compared to MGL-3196, positioning it as a promising treatment for lipid disorders.
Four pairs of cinnamoyl-β-triketone derivative enantiomers, (+)- and (-)-xanthostones A-D ((+)- and (-)-1-4), were isolated from Xanthostemon chrysanthus. Compounds 1 and 2 feature a new rearranged cinnamoyl-phloroglucinol scaffold fused with a cinnamyl-β-triketone framework. Compounds 1, 3, and 4 are the first examples of natural products with a peculiar phenethyl-pyranone acid unit.
View Article and Find Full Text PDF[Animal model analysis of knee osteoarthritis based on clinical characteristics of Chinese and Western medicine].
Zhongguo Zhong Yao Za Zhi
June 2020
Knee osteoarthritis(KOA) is a common orthopedic disease. Its main symptoms include pain in the medial knee, aggravated knee pain during walking, limited movement, and joint deformity, which seriously affect the daily life of patients. The replication of animal models consistent with clinical symptoms is the premise of KOA-related experimental research.
View Article and Find Full Text PDFStudy the effect of stachydrine hydrochloride to prostatic hyperplasia in mice which made of the urogenital sinus implantation. KM male mices were selected. The group was given the respective drugs for gavage, the group of BG and MG were given the distilled water which the same amount as the drugs group for 21 consecutive days.
View Article and Find Full Text PDFArticle Synopsis
- Desertliving Cistanche herb, recognized in ancient texts as a high-grade herbal medicine, contains phenylethanoid glycosides, which are important for its identification and medicinal properties.
- This study investigates the effects of these glycosides on perimenopausal syndrome using a model of female rats that simulate menopause.
- The research involved surgical removal of ovaries in rats to induce menopause, followed by administration of various doses of phenylethanoid glycosides, with subsequent measurement of hormonal levels and examination of reproductive organ health.
[Study on function evaluation of health food containing Chinese materia medica based on data mining].
Zhongguo Zhong Yao Za Zhi
March 2019
Article Synopsis
- - The relationship between medicine and food in Chinese medicine plays a crucial role in guiding the creation of health foods that incorporate traditional medicinal ingredients, particularly in light of China's National Healthy China 2030 initiative.
- - Current research focuses on extracting functional components and evaluating the effectiveness and safety of health foods that use Chinese herbs, but there are gaps in understanding traditional medicine principles and developing appropriate evaluation systems.
- - New databases and research platforms are being established to better analyze the efficacy, safety, and compatibility of Chinese medicinal ingredients, which will contribute to the development and assessment of health foods containing these materials.
Background: Most reports have indicated the antioxidant capacity of quinoa seeds. However, the leaves of Quinoa (Chenopodium quinoa Willd.) are usually worthless and little known about their biological activities.
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