Reimagining cancer tissue classification: a multi-scale framework based on multi-instance learning for whole slide image classification.

In cancer pathology diagnosis, analyzing Whole Slide Images (WSI) encounters challenges like invalid data, varying tissue features at different magnifications, and numerous hard samples. Multiple Instance Learning (MIL) is a powerful tool for addressing weakly supervised classification in WSI-based pathology diagnosis. However, existing MIL frameworks cannot simultaneously tackle these issues.

Glucose Metabolism and Glucose Transporters in Head and Neck Squamous Cell Carcinoma.

Head and neck squamous cell carcinoma ranks seventh globally in malignancy prevalence, with persistent high mortality rates despite treatment advancements. Glucose, pivotal in cancer metabolism via the Warburg effect, enters cells via glucose transporters, notably GLUT proteins. Glycolysis, aerobic oxidation, and the pentose phosphate pathway in glucose metabolism significantly impact HNSCC progression.

Containment control for fractional-order networked system with intermittent sampled position communication.

This paper investigates containment control for fractional-order networked systems. Two novel intermittent sampled position communication protocols, where controllers only need to keep working during communication width of every sampling period under the past sampled position communication of neighbors' agents. Then, some necessary and sufficient conditions are derived to guarantee containment about the differential order, sampling period, communication width, coupling strengths, and networked structure.

Network meta-analysis of adjuvant treatments for patients with hepatocellular carcinoma after curative resection.

Purpose: The prevention of recurrence for patients with hepatocellular carcinoma after curative resection is still a great challenge in clinical practice. There are numerous studies that trying to search for favorable strategies to decrease the recurrence and prolong life span for these patients, whereas no consensus is reached till now. Herein, we aim to compare the efficacy between different reported treatments by network meta-analysis(NMA).

Glutamine metabolic reprogramming in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming. The components of glutamine metabolism, such as glutamine synthetase, glutamate dehydrogenase, glutaminase, metabolites, and metabolite transporters, are validated to be potential biomarkers of HCC.

Passivity and passification of fractional-order memristive neural networks with time delays.

A class of fractional-order memristive neural networks (FMNNs) with time delays is studied. At first, the original network system is converted to fractional-order uncertain one to simplify the analysis by a variable transformation. Successively, some new LMIs-based passivity criteria are derived by differential inclusions, set-valued maps, inequality techniques and linear matrix inequality approach.

Reduction in right lateralized N2 error response to stroke order violations in poor Chinese word spellers: A study on event-related potential markers for Chinese reading and spelling.

Stroke order knowledge is critical for Chinese reading and spelling acquisition. Previous studies have demonstrated enhancements of the N2 and P3 event-related potential (ERP) components at the Pz electrode to stroke order violations of Chinese characters in younger adults. However, it remained unclear whether similar ERP responses could be found in children.

Effectiveness of parent coaching on the literacy skills of Hong Kong Chinese Children with and without dyslexia.

Literacy skills are important for children's development. The present study explored the effectiveness of a parent coaching approach on the reading and spelling skills and compared cognitive-linguistic skills performances between Chinese children with and without dyslexia. Participants were 33 children with dyslexia and 77 children without dyslexia, as well as their parent, in Hong Kong.

Spelling as a way to classify poor Chinese-English literacy skills in Hong Kong Chinese children.

Previous work has predominantly focused on word reading in studying literacy difficulties; very little work has focused on spelling difficulty instead. The present study adopted spelling (dictation) as the criterion to classify poor literacy skills in Hong Kong Chinese-English bilingual children. We examined the cognitive-linguistic skills profiles across four groups of children with different spelling abilities.

Role of the Long Intergenic Non-Protein-Coding RNA 1278/miR-185-5p/Cystatin SN Axis in Laryngeal Cancer Cells.

Laryngeal cancer accounts for 25%-30% of tumors in the head and neck. Cystatin SN (CST1) was revealed to show upregulated expression in this cancer, while its functions and upstream pathway remain unknown and need investigation. The current study was designed to solve this problem.

Constructing Environmental-Friendly "Oil-Diode" Janus Membrane for Oil/Water Separation.

Oil leakage is a global environmental issue and happens frequently, resulting in a waste of oil resources and even threatening the safety of marine creatures and humans. Because of unidirectional oil transportation performance, "oil-diode" Janus membranes have attracted lots of attention for oil/water separation. However, the hydrophobic side of traditional "oil-diode" Janus membrane is completely hydrophobic, resulting in an easy permeation of oil, which hampers light oil recycling.

SHED-derived exosomes improve the repair capacity and osteogenesis potential of hPDLCs.

Objective: Exosomes secreted by stem cells are recognized as a critical component in tissue regeneration during stem cell-based therapy. Considering the limited sources and bone regeneration efficiency of human periodontal ligament cells (hPDLCs), we explored whether exosomes secreted by stem cells from human exfoliated deciduous teeth (SHED-exo) could improve the pluripotency and regenerative potential of hPDLCs.

Methods And Materials: In hPDLCs, cell proliferation, migration, cell cycle, apoptosis, and osteogenic differentiation were detected after cells were exposed to SHED-exo (SHED-exo group), blank (control group), or control supernatant without exo (Csup group), via CCK-8, scratch analysis, flow cytometric, real-time PCR, and so on.

CTRP13 Protects H9c2 Cells Against Hypoxia/Reoxygenation (H/R)-Induced Injury Via Regulating the AMPK/Nrf2/ARE Signaling Pathway.

Myocardial infarction (MI) is identified as the myocardial necrosis due to myocardial ischemia/reperfusion (I/R) injury and remains a leading cause of mortality. C1q/TNF-related protein 13 (CTRP13) is a member of CTRP family that has been found to be involved in coronary artery disease (CAD). However, the role of CTRP13 in MI remains unclear.

A Model of Chinese Spelling Development in Hong Kong Kindergarteners.

Copying characters presented previously (delayed copying) is an important skill in Chinese literacy acquisition. The relations of delayed copying and a set of literacy-related skills (including vocabulary knowledge, rapid automatized naming, phonological awareness, morphological awareness, and orthographic awareness), visual-orthographic judgment, motor coordination, pure copying of foreign scripts, and delayed copying to Chinese spelling were examined among 294 typically developing Hong Kong kindergarteners. With all other variables statistically controlled, rapid automatized naming, phonological awareness, morphological awareness, orthographic awareness, motor coordination, and delayed copying all uniquely explained Chinese spelling.

SHED-derived conditioned exosomes enhance the osteogenic differentiation of PDLSCs via Wnt and BMP signaling in vitro.

The exosomes from human exfoliated deciduous teeth (SHED-Exos) have exhibited potential therapeutic role in dental and oral disorders. The biological effects of exosomes largely depend on cellular origin and physiological status of donor cell. In the present study, we explored the influence of conditioned exosomes from SHED with osteogenic induction on periodontal ligament stem cells (PDLSCs) in vitro.

Semi-Global Output Consensus for Discrete-Time Switching Networked Systems Subject to Input Saturation and External Disturbances.

The semi-global output consensus problem for multiagent systems depicted by discrete-time dynamics subject to external disturbances and input saturation over switching networks is investigated in this paper. Assume that only a small part of subsystems have directly received the output of the exosystem. The distributed consensus algorithms are proposed by adopting the low-gain state feedback and the modified algebraic Riccati equation.

A Geometric Approach to Second-Order Consensus of Heterogeneous Networked Systems.

This paper investigates second-order consensus of networked systems with heterogeneous intrinsic nonlinear dynamics via a geometrical method, in which the nonlinear dynamics are governed by both velocity and position. First, two necessary conditions are deduced for the existence of consensus solutions by analyzing the inherent nonlinear dynamics of isolated nodes. Then a closed invariant set is constructed via geometrical methods.

Effect of Gratitude on Benign and Malicious Envy: The Mediating Role of Social Support.

Gratitude has been investigated in various areas in psychology. The present research showed that gratitude had some positive effects on some aspects of our life, such as subjective well-being, life satisfaction, and social relationships. It can also help us relieve negative emotions.

Event-triggered Kalman-consensus filter for two-target tracking sensor networks.

This paper is concerned with the problem of event-triggered Kalman-consensus filter for two-target tracking sensor networks. According to the event-triggered protocol and the mean-square analysis, a suboptimal Kalman gain matrix is derived and a suboptimal event-triggered distributed filter is obtained. Based on the Kalman-consensus filter protocol, all sensors which only depend on its neighbors' information can track their corresponding targets.

Working memory operates over the same representations as attention.

A recent study observed a working memory (WM) Stroop effect with a magnitude equivalent to that of the classic Stroop effect, indicating that WM operates over the same representations as attention. However, more research is needed to examine this proposal. One unanswered question is whether the WM Stroop effect occurs when the WM item and the perceptual task do not have an overlapping response set.

The Positivity Bias Phenomenon in Face Perception Given Different Information on Ability.

The negativity bias has been shown in many fields, including in face processing. We assume that this bias stems from the potential threat inlayed in the stimuli (e.g.

Systemically Transplanted Bone Marrow-derived Cells Contribute to Dental Pulp Regeneration in a Chimeric Mouse Model.

Introduction: Migratory cells via blood circulation or cells adjacent to the root apex may potentially participate in dental pulp tissue regeneration or renewal. This study investigated whether systemically transplanted bone marrow cells can contribute to pulp regeneration in a chimeric mouse model.

Methods: A chimeric mouse model was created through the injection of bone marrow cells from green fluorescent protein (GFP) transgenic C57BL/6 mice into the tail veins of recipient wild-type C57BL/6 mice that had been irradiated with a lethal dose of 8.

Prior exposure to imatinib does not impact outcome of allogeneic hematopoietic transplantation for chronic myeloid leukemia patients: a single-center experience in china.

Objective: We conducted a retrospective single-center study of 106 patients to investigate the impact of prior exposure to imatinib before allogeneic hematopoietic stem cell transplantation (allo-HSCT) on outcome of HSCT for chronic myeloid leukemia (CML) in china.

Methods: Patients were divided into imatinib and non-imatinib group according to whether receiving imatinib therapy before transplantation or not. Hematopoietic engraftment, prognosis, congestive heart failure (CHF), hepatic veno-occlusive disease (HVOD), graft versus host disease (GVHD), hemorrhagic cystitis and infections were compared between the two groups in early stage of transplantation (within 100 days after transplantation).