Publications by authors named "Yanyan Shi"

Cerebral hemorrhage is a serious cerebrovascular disease with high morbidity and high mortality, for which timely diagnosis and treatment are crucial. Electrical impedance tomography (EIT) is a functional imaging technique which is able to detect abnormal changes of electrical property of the brain tissue at the early stage of the disease. However, irregular multi-layer structure and different conductivity properties of each layer affect image reconstruction of the brain EIT, resulting in low reconstruction quality.

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Unlabelled: Pneumonia is the leading cause of morbidity and mortality in children and needs rapid and accurate pathogenic diagnosis. The aim of this study was to evaluate the diagnostic value of bronchoalveolar lavage fluid (BALF) metagenomic next-generation sequencing (mNGS) and conventional microbiological tests (CMTs) for pathogen detection in children with severe or refractory pneumonia. In this retrospective study, the clinical data of 127 children with severe or refractory pneumonia admitted to the respiratory department from June 2021 to March 2022 were analyzed.

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The Kirsten rat sarcoma viral oncogene homolog (KRAS) protein plays a key pathogenic role in oncogenesis, cancer progression, and metastasis. Numerous studies have explored the role of metabolic alterations in KRAS-driven cancers, providing a scientific rationale for targeting metabolism in cancer treatment. The development of KRAS-specific inhibitors has also garnered considerable attention, partly due to the challenge of acquired treatment resistance.

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Delivery systems play a crucial role in RNA therapy. However, the current RNA delivery system involves complex preparation and transport processes, requiring RNA preassembly , transportation at low temperatures throughout, and possibly multiple injections for improved therapeutic efficacy. To address these challenges, we developed a simple and efficient RNA delivery system.

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Unlabelled: Genotypic methods for detecting antibiotic resistance in infection offer a rapid, convenient, and accurate approach for tailored therapy. However, existing studies predominantly examine single sample types and lack comparative analyses across different samples. This study comprehensively detects and compares genotypic resistance to clarithromycin and levofloxacin in gastric mucosa, gastric fluid, and fecal samples from the same patients.

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Background: Understanding the global burden and risk factors of non-rheumatic valvular heart disease (NRVHD) in older adults is important for effective disease control. We wanted to analyze the prevalence, incidence, disability-adjusted life years (DALY) rate, mortality rate, and risk factors of NRVHD in older adults aged 60-89 years.

Methods: Global Burden of Disease Study (GBD) 2019 was used as the data source.

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Background: Inflammatory bowel diseases (IBD) are chronic inflammation conditions affecting the gastrointestinal tract. Studies point out an association between () infection and IBD. This study aims to visually assess the research trends and hotspots in the field of infection and IBD, review mainstream perspectives in this field, and provide a foundation for future research and treatment.

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Background: Hyperplastic polyps, which represent 30%-93% of all gastric epithelial polyps, are the second most common type of gastric polyps after fundic gland polyps. They were previously considered to have no risk of neoplastic transformation. Recently, an increasing number of cases of gastric hyperplastic polyps (GHPs) combined with neoplastic changes have been reported; however, the specific mechanism underlying their transformation has not been thoroughly explored.

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The goal of the study was to assess the impact of deep inspiration breath hold technique (DIBH), surface-guided radiotherapy (SGRT), and daily kilovoltage cone-beam computed tomography (kV-CBCT) on the dose to organs at risk (OAR) in left-sided breast cancer radiotherapy. Twenty-six consecutive left-sided breast cancer patients treated using Volumetric Intensity Modulated Arc Therapy (VMAT), DIBH, SGRT, and a hypofractionated regimen were retrospectively evaluated in this study. Dose parameters were extracted from dose-volume histograms (DVH).

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Objective: Phenotypes are important for patient classification, disease prognostication, and treatment customization. We aimed to identify distinct clinical phenotypes of children and adolescents hospitalized with SARS-CoV-2 infection, and to evaluate their prognostic differences.

Methods: The German Society of Pediatric Infectious Diseases (DGPI) registry is a nationwide, prospective registry for children and adolescents hospitalized with a SARS-CoV-2 infection in Germany.

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() colonizes the human stomach and many studies have discussed the mechanisms of infection leading to gastric diseases, including gastric cancer. Additionally, increasing data have shown that the infection of may contribute to the development of extra-gastric diseases and tumors. Inflammation, systemic immune responses, microbiome disorders, and hypergastrinemia caused by infection are associated with many extra-gastric malignancies.

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Article Synopsis
  • Uncaria rhynchophylla (UR) has neuroprotective properties and has shown promise in treating Parkinson's disease (PD) due to its active alkaloid components, although more research is needed on its therapeutic effects and mechanisms.
  • The study investigates UR's alkaloid extract (URA) using methods like LC-MS and proteomics to evaluate its chemical composition and anti-PD activity in animal models, along with its effects on dopaminergic neurons.
  • Results indicate that URA significantly improves motor functions in PD models and enhances dopamine levels and related proteins, suggesting it may work through pathways involving oxidative phosphorylation and mitochondrial function.
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Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Current treatments mainly rely on immunosuppressants, which lack specificity and pose challenges during treatment. This study aims to deeply explore the molecular pathogenic mechanism of SLE through gene expression databases (GEO) and bioinformatics analysis methods, combined with Mendelian randomization analysis, to provide key clues for new therapeutic targets.

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Tumor immunotherapy has been widely used in clinical treatment of various cancers. However, some patients of these cancers do not respond to immunotherapy effectively. And infection has been considered to be related to the efficacy of immunotherapy.

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  • The marbled flounder (Pseudopleuronectes yokohamae) is valued for its nutrition and taste, but lacks extensive transcriptome data which is important for disease research.
  • A study sequenced the skin transcriptome using Nanopore technology, yielding 30,498 transcripts and identifying key immune-related genes and pathways.
  • The research highlighted four families of antimicrobial peptides (AMPs) in the flounder and demonstrated their potential in boosting knowledge about fish immunity and disease prevention.
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  • Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder with varying global prevalence, making an understanding of its epidemiological aspects crucial for effective control and prevention.
  • The objective of this study was to update global estimates on IBD's impact, analyzing its prevalence, incidence, and disability-adjusted life years (DALY) across different regions and socio-economic backgrounds.
  • From 1990 to 2019, IBD maintained high global prevalence and incidence rates, with men experiencing higher DALY rates; North America had the highest rates overall, while Oceania had the lowest.
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  • Hemorrhage is a common complication in gastric cancer patients, potentially leading to worse outcomes, but its effect on chemotherapy effectiveness has not been studied before.
  • This study analyzed advanced or metastatic gastric and gastroesophageal junction cancer patients to see how overt bleeding (OB) impacts survival rates and treatment-related side effects.
  • Results showed similar disease control rates and treatment-related adverse events for patients with and without overt bleeding before treatment, but those with bleeding after treatment had a worse median overall survival than those without bleeding.*
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The study aimed to reveal the function of LXY30 peptide-modified bone marrow mesenchymal stem cell-derived exosomes (LXY30-Exos) in NSCLC. LXY30 peptide is a peptide ligand targeting α3β1 integrin, and LXY30 specifically binds to Exos derived from different cells. We use transmission electron microscopy to identify LXY30-Exos and tracking analysis for particles, and the LXY30-Exos internalized by NSCLC cells in vitro and targeted NSCLC tumours in vivo were verified by multiple molecular technologies.

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In unsupervised domain adaptive object detection, learning target-specific features is pivotal in enhancing detector performance. However, previous methods mostly concentrated on aligning domain-invariant features across domains and neglected integrating the specific features. To tackle this issue, we introduce a novel feature learning method called Joint Feature Differentiation and Interaction (JFDI), which significantly boosts the adaptability of the object detector.

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Background: The intrapapillary capillary loop (IPCL) characteristics, visualized using magnifying endoscopy, are commonly assessed for preoperative evaluation of the infiltration depth of esophageal squamous cell carcinoma (ESCC). Japan Esophageal Society (JES) classification is the most widely used classification. Microvascular structural changes are evaluated by magnifying endoscopy for the presence or absence of each morphological factor: tortuosity, dilatation, irregular caliber, and different shapes.

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Engineered bacteria-based cancer therapy has increasingly been considered to be a promising therapeutic strategy due to the development of synthetic biology. Wherein, engineering bacteria-mediated photodynamic therapy (PDT)-immunotherapy shows greater advantages and potential in treatment efficiency than monotherapy. However, the unsustainable regeneration of photosensitizers (PSs) and weak immune responses limit the therapeutic efficiency.

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CagA, a virulence factor of (), is known to drive inflammation in gastric epithelial cells and is typically degraded through autophagy. However, the molecular mechanism by which CagA evades autophagy-mediated degradation remains elusive. This study found that inhibits autophagic flux by upregulating the expression of AU-rich element RNA-binding factor 1 (AUF1).

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Background: Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease, often leading to neuroinflammation and neuronal damage. Activation of the Nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is closely associated with post-SAH neuroinflammation, while activation of Nicotinamide Adenine Dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1) has neuroprotective effects. This study aimed to investigate the impact of injectable Collagen Binding Domain-Brain Derived Neurotrophic Factor (CBD-BDNF) on neuroinflammation and neuronal damage following SAH.

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Article Synopsis
  • There has been an increase in pregnancies complicated by gestational diabetes mellitus (GDM), linked to glucose intolerance during pregnancy.
  • Analysis of placental tissue from these pregnancies shows that GDM placentas are larger and heavier, suggesting changes in cell growth and death processes.
  • RNA sequencing identified 935 genes increased and 256 decreased in GDM placentas, with findings indicating the involvement of the PI3K/Akt signaling pathway in GDM development, particularly through the regulation of certain matrix metalloproteinases and alternative splicing patterns.
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Etomidate is a general anesthetic that has shown good hemodynamic stability without significant cardiovascular or respiratory depression. Despite several kinds of dosage forms having been reported for this drug, formulation types are very limited in clinical practice, and brain-targeted formulations for this central nervous system (CNS) drug have been rarely reported. Moreover, studies on the biocompatibility, toxicity, and anesthetic effects of the etomidate preparations in vivo were inadequate.

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Synopsis of recent research by authors named "Yanyan Shi"

  • - Yanyan Shi's recent research primarily focuses on the interplay between various infections and diseases, highlighting how infections can lead to the development of extra-gastric tumors and influence the efficacy of cancer immunotherapy.
  • - His studies also explore the therapeutic potentials of natural products and bioinformatics in chronic conditions such as systemic lupus erythematosus and the neuroprotective effects of compounds like Uncaria rhynchophylla against neurodegenerative diseases.
  • - Additionally, Shi investigates the molecular mechanisms underlying various health conditions, including gestational diabetes and gastric cancer, aiming to identify novel therapeutic targets and improve treatment outcomes through innovative approaches like engineered bacteria for cancer therapy.

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