Bimetallic nanozymes for effectively removing Enterococcus faecalis biofilms in pulp and periapical infection treatment.

Pulpal and periapical infections, primarily caused by the biofilms of Enterococcus faecalis (E. faecalis), pose significant challenges due to their resistance to eradication, making them prevalent oral health concerns. Herein, we synthesized a bimetallic Zn-Fe nanozymes (ZFNs) with enhanced peroxidase-like (POD-like) activity, capable of activating hydrogen peroxide (HO) into highly reactive hydroxyl radicals to combat E.

Endodontic treatment of the mandibular first molar with six root canals: A case report and literature review.

The mandibular first molars normally have three or four root canals and rarely have five or more root canals. The present study reported a rare anatomical configuration with six root canals in the mandibular right first molar diagnosed during endodontic treatment using a dental operating microscope and confirmed with the help of cone-beam computed tomography (CBCT) images. The present case report revealed that there is an increasing possibility of detecting additional canals through the magnification of the microscope and the improvement of CBCT diagnostic technology.

Osteoprotegerin/receptor activator of nuclear factor-κB ligand are involved in periodontitis-promoted vascular calcification.

The present study explored the potential role of osteoprotegerin (OPG)/receptor activator of nuclear factor-κB (RANK)/receptor activator of nuclear factor-κB ligand (RANKL) in promoting vascular calcification by periodontitis. Thirty-six male Wistar rats were randomly assigned to four groups to establish animal models as follows: the sham group (group C), vascular calcification group (group VDN), periodontitis group (group CP), and test group (group CP+VDN). After eight weeks, all the rats were sacrificed.