Prognostic value of platelet combined with serum procalcitonin in patients with sepsis.

Sepsis, a common and life-threatening condition in critically ill patients, is a leading cause of death in intensive care units. Over the past few decades, there has been significant improvement in the understanding and management of sepsis. However, the mortality rate remains unacceptably high, posing a prominent challenge in modern medicine and a significant global disease burden.

Application of Logistic Regression and Artificial Intelligence in the Risk Prediction of Acute Aortic Dissection Rupture.

Logistic regression (LR) and artificial intelligence algorithms were used to analyze the risk factors for the early rupture of acute type A aortic dissection (ATAAD). Data from electronic medical records of 200 patients diagnosed with ATAAD from the Department of Emergency of Guangdong Provincial People’s Hospital from April 2012 to March 2017 were collected. Logistic regression and artificial intelligence algorithms were used to establish prediction models, and the prediction effects of four models were analyzed.

[Role of nicotinamide phosphoribosyltransferase in delaying smooth muscle cell senescence and protecting abdominal aortic aneurysm].

Objective: To investigate the protective effect of nicotinamide phosphoribosyltransferase (NAMPT) on abdominal aortic aneurysm by delaying the senescence of aortic vascular smooth muscle cells (VSMC).

Methods: The primary VSMC cells from normal and patients with abdominal aortic aneurysm were cultured by tissue adherence method. Cells were divided into normal human-derived VSMC group (Ctrl-VSMC group), abdominal aortic aneurysm patient-derived VSMC group (AAA-VSMC group), and angiotensin II (Ang II) in vitro abdominal aortic aneurysm model group (Ang II-VSMC group, 100 nmol/L Ang II treated normal human-derived VSMC for 48 hours), Ang II + P7C3 group and AAA + P7C3 group after NAMPT agonist P7C3 intervention (adding 5 μmol/L P7C3 on the basis of Ang II-VSMC group and AAA-VSMC group, respectively).

Pancreatic cancer: A review of epidemiology, trend, and risk factors.

Despite rapid advances in modern medical technology and significant improvements in survival rates of many cancers, pancreatic cancer is still a highly lethal gastrointestinal cancer with a low 5-year survival rate and difficulty in early detection. At present, the incidence and mortality of pancreatic cancer are increasing year by year worldwide, no matter in the United States, Europe, Japan, or China. Globally, the incidence of pancreatic cancer is projected to increase to 18.