CDC20-Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma.

Polybromo 1 (PBRM1) inactivating mutations are associated with clinical benefit from immune checkpoint inhibitor treatments in clear cell renal cell carcinoma (ccRCC). However, whether targeting PBRM1 has the potential to enhance immunotherapy efficacy in patients with wild-type PBRM1 and the upstream pathways that regulate PBRM1 protein stability remain unclear. Here, it is demonstrated that PBRM1 knockdown induced M1 macrophage polarization and infiltration, which enhanced the efficacy of anti-PD-1 immunotherapy in RCC.

Recycling BC grinding waste to fabricate high-performance ceramics by modification treatments and hot pressing.

BC grinding waste, originated from the fine grinding process of sapphire wafers, is discarded without reutilization, which causes environmental pollution and resource waste. This work proposes new methods on recycling BC grinding waste to fabricate high-performance ceramics by first modification treatments via ball-milling mixing or microwave digestion with sulfuric acid and then hot pressing. The characteristic of BC grinding waste is studied and AlO is the main impurity.

Role of heat shock protein 70 in silibinin-induced apoptosis in bladder cancer.

Hsp70 (heat shock protein 70) plays critical roles in cancer cell proliferation and apoptosis. Recently, accumulating evidences have demonstrated the cancer promoting effects of Hsp70 in bladder cancer. The development of novel therapeutic approaches targeting Hsp70 thus received great attention from researchers.

Leaching kinetic mechanism of iron from the diamond wire saw silicon powder by HCl.

The diamond wire saw silicon powder (DWSSP) is considered to be a harmful to the environment because of finer particles, the large specific surface area and flammability. Removal of Fe impurity is very essential for recovering Si from DWSSP due to the large amount of Fe introduced during the silicon powder generation process. In the study, the thermodynamics of Fe leaching with HCl was analyzed and determined iron was theoretically present as ions in solution.

Efficient recycling of silicon cutting waste for producing high-quality Si-Fe alloys.

A tremendous amount of silicon cutting waste (SCW) is being produced during slicing Si ingots, which leads to a great waste of resources and serious environmental pollution. In this study, a novel method that recycling SCW to produce Si-Fe alloys was proposed, which not only provides a process with low energy consumption, low cost, and short flow for producing high-quality Si-Fe alloys but also achieves a more effective recycling of SCW. The optimal experimental condition is investigated to be a smelting temperature of 1800 °C and a holding time of 10 min.

Sperm-borne proteins improve rabbit cloning efficiency via regulating embryonic cleavage and epigenetics.

Somatic cell nuclear transfer (SCNT) shows great application value in the generation of transgenic animals, protection of endangered species, and therapeutic cloning. However, the cloning efficiency is still very low, which greatly restricts its application. Compared to fertilized embryos, cloned embryos lack the sperm proteins, which are considered to play an important role in embryonic development.

Efficient recycling of silicon cutting waste by AlSi alloying with the assistance of cryolite.

Silicon cutting waste (SCW) generated during Si wafers producing process can be recycled by AlSi alloying process. However, the presence of O in SCW has a detrimental impact on recycling process. In this study, cryolite was introduced to eliminate the hindrance of O.

Preparation of Al-Si alloys with silicon cutting waste from diamond wire sawing process.

Large amounts of silicon cutting waste (SCW) are generated during Si wafers producing process. In this paper, SCW was mixed with Al powder to prepare Al-Si alloys by a one-step smelting process in corundum crucibles. The influences of smelting temperature (1000 °C, 1200 °C and 1500 °C) on the products of each zone (surface layer zone, loose granular zone and blocky products zone) were investigated.

Preparation of reactive sintering SiN-SiNO composites ceramics with diamond-wire saw powder waste as raw material.

In this paper, the reactive sintering SiN-SiNO composites ceramics were fabricated from the diamond-wire saw powder through the reaction-sintering nitridation method. The effects of sintering temperatures, holding time and oxygen contents on the SiN-SiNO composites formation were investigated in detail. The results revealed that the phases of final products consisted of α/β-SiN and SiNO, and the proportion of three phases could be influenced by sintering temperatures and oxygen contents.

Recycling of silicon from silicon cutting waste by Al-Si alloying in cryolite media and its mechanism analysis.

More than 40% of the crystalline silicon has been wasted as silicon cutting waste (SCW) during the wafer production process. This waste not only leads to resource wastage but also causes environmental burden. In this paper, SCW produced by the diamond-wire sawing process was recycled by Al-Si alloying process.

Effect of Annealing on Microstructure and Mechanical Properties of AlCoCrFeMoNi High-Entropy Alloys.

The effect of annealing temperature on the microstructure, phase constituents and mechanical properties of AlCoCrFeMoNi high-entropy complex alloys has been investigated at a fixed annealing time (10 h). The 600 °C-annealing has no obvious effect on their microstructures, while the annealing at 800-1200 °C enhances the precipitation of (Al,Ni)-rich ordered BCC phase or/and (Cr,Mo)-rich σ phase, and thereby greatly affects the microstructure and mechanical properties of the alloys. All the annealed AlCoCrFeNi alloys are composed of FCC and (Al,Ni)-rich ordered BCC phases; the phase constituent of the AlCoCrFeMoNi alloy changes from FCC + BCC (600 °C) to FCC + BCC + σ (800 °C) and then to FCC + BCC (1100 °C); the phase constituents of the AlCoCrFeMoNi and AlCoCrFeMoNi alloys change from FCC + BCC + σ to FCC + BCC with the annealing temperature rising from 600 to 1200 °C; while all the annealed AlCoCrFeMoNi and AlCoCrFeMoNi alloys consist of FCC, BCC and σ phases.