Hook.f. & Thomson (CC) is a traditional medicinal herb with multiple biological activities.
View Article and Find Full Text PDFPlant height is a critical agronomic trait that affects crop yield, plant architecture, and environmental adaptability. Gibberellins (GAs) regulate plant height, with DELLA proteins acting as key repressors in the GA signaling pathway by inhibiting GA-induced growth. While DELLA phosphorylation is essential for regulating plant height, the precise mechanisms underlying this process remain incompletely understood.
View Article and Find Full Text PDFDwarf or semidwarf plant structures are well suited for intensive farming, maximizing yield, and minimizing labor costs. Watermelon (Citrullus lanatus) is classified as an annual vine plant with elongated internodes, yet the mechanism governing watermelon dwarfing remains unclear. In this study, a compact watermelon mutant dwarf, induced by the insertion of transferred DNA (T-DNA), was discovered.
View Article and Find Full Text PDFIntroduction: In light of the public health burden of the COVID-19 pandemic, boosting the safety and immunogenicity of COVID-19 vaccines is of great concern. Numerous Traditional Chinese medicine (TCM) preparations have shown to beneficially modulate immunity. Based on pilot experiments in mice that showed that supplementation with Huoxiang Suling Shuanghua Decoction (HSSD) significantly enhances serum anti-RBD IgG titers after inoculation with recombinant SARS-CoV-2 S-RBD protein, we conducted this randomized, double-blind, placebo-controlled clinical trial aimed to evaluate the potential immunogenicity boosting effect of oral HSSD after a third homologous immunization with Sinovac's CoronaVac SARS-CoV-2 (CVS) inactivated vaccine.
View Article and Find Full Text PDFCucumber (Cucumis sativus, Cs) tendrils are slender vegetative organs that typically require manual removal to ensure orderly growth during greenhouse cultivation. Here, we identified cucumber tendril-less (tl), a Tnt1 retrotransposon-induced insertion mutant lacking tendrils. Map-based cloning identified the mutated gene, CsaV3_3G003590, which we designated as CsTL, which is homologous to Arabidopsis thaliana LATERAL SUPPRESSOR (AtLAS).
View Article and Find Full Text PDFIntroduction: The lack of safe, effective, and simple short-course regimens (SCRs) for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment has significantly impeded TB control efforts in China.
Methods: This phase 4, randomized, open-label, controlled, non-inferiority trial aims to assess the efficacy and safety of a 9-month all-oral SCR containing bedaquiline (BDQ) versus an all-oral SCR without BDQ for adult MDR-TB patients (18-65 years) in China. The trial design mainly mirrors that of the "Evaluation of a Standardized Treatment Regimen of Anti-Tuberculosis Drugs for Patients with MDR-TB" (STREAM) stage 2 study, while also incorporating programmatic data from South Africa and the 2019 consensus recommendations of Chinese MDR/RR-TB treatment experts.
Uranyl cation, as an emerging photocatalyst, has been successfully applied to synthetic chemistry in recent years and displayed remarkable catalytic ability under visible light. However, the molecular-level reaction mechanisms of uranyl photocatalysis are unclear. Here, we explore the mechanism of the stepwise benzylic C-H oxygenation of typical alkyl-substituted aromatics (i.
View Article and Find Full Text PDFPhotocatalytic technology has received increasing attention in recent years. A pivotal facet of photocatalytic technology lies in the development of photocatalysts. Porous metal-organic framework (MOF) materials, distinguished by their unique properties and structural characteristics, have emerged as a focal point of research in the field, finding widespread application in the photo-treatment and conversion of various substances.
View Article and Find Full Text PDFThe grass carp (Ctenopharyngodon idella) is the world's most prolific freshwater fish. Little is known, however, about the functional genes and genetic regulatory networks that govern its growth traits. We created three grass carp families in this study by using two grass carp parents with fast-growing offspring and two grass carp parents with slow-growing offspring, namely the fast-growing × fast-growing family (FF), the slow-growing × slow-growing family (SS), and the fast-growing × slow-growing family (FS).
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2023
The investigation of high-performance polymer-based electrolytes holds significant importance for advancing the development of next-generation lithium metal batteries (LMBs). In this work, a quasi-solid-state electrolyte (EFA-G) comprising pyrrolidinium type polymeric ionic liquids and fluoropolymers was synthesized through a photoinitiated free radical copolymerization process in the presence of solvate ionic liquids. EFA-G not only exhibited high ionic conductivity (9.
View Article and Find Full Text PDFCorrosion resistant, durable, and lightweight flexible strain sensor with multiple functionalities is an urgent demand for modern flexible wearable devices. However, currently developed wearable devices are still limited by poor environmental adaptability and functional singleness. In this work, a conductive fabric with multifunctionality in addition to sensing was successfully prepared by assembling zero dimensional silver nanoparticles (AgNPs) and one-dimensional carbon nanotubes (CNTs) layer by layer on the surface of the elastic polypropylene nonwoven fabric (named PACS fabric).
View Article and Find Full Text PDFThe lateral organs of watermelon (Citrullus lanatus), including lobed leaves, branches, flowers, and tendrils, together determine plant architecture and yield. However, the genetic controls underlying lateral organ initiation and morphogenesis remain unclear. Here, we found that knocking out the homologous gene of shoot branching regulator LATERAL SUPPRESSOR in watermelon (ClLs) repressed the initiation of branches, flowers, and tendrils and led to developing round leaves, indicating that ClLs undergoes functional expansion compared with its homologs in Arabidopsis (Arabidopsis thaliana), rice (Oryza sativa), and tomato (Solanum lycopersicum).
View Article and Find Full Text PDFSolid-state ionic conductive elastomers (ICEs) can fundamentally overcome the disadvantages of hydrogels and ionogels (their liquid components tend to leak or evaporate), and are considered to be ideal materials for flexible ionic sensors. In this study, a liquid-free ionic polyurethane (PU) type conductive elastomer (ICE-2) was synthesized and studied. The PU type matrix with microphase separation endowed ICE-2 with excellent mechanical versatility.
View Article and Find Full Text PDFLight signals promote photomorphogenesis and photosynthesis, allowing plants to establish photoautotrophic growth. Chloroplasts are organelles responsible for photosynthesis in which light energy is converted into chemical energy and stored as organic matter. However, how light regulates chloroplast photomorphogenesis remains unclear.
View Article and Find Full Text PDFClin Pharmacol Drug Dev
February 2023
JNJ-73763989, composed of the 2 short-interfering RNA triggers JNJ-73763976 and JNJ-73763924, targets all hepatitis B virus messenger RNAs, thereby reducing all viral proteins. In this phase 1, single-site, open-label, parallel-group, randomized study, participants were given 1 subcutaneous injection of JNJ-73763989 (100 or 200 mg) to investigate the pharmacokinetics, safety, and tolerability of JNJ-73763989 in healthy Chinese adult participants. Plasma and urine pharmacokinetic parameters were determined for each trigger up to 48 hours after dosing.
View Article and Find Full Text PDFA high-quality baseline transcriptome is a valuable resource for developmental research as well as a useful reference for other studies. We gathered 41 samples representing 11 tissues/organs from 22 important developmental time points within 197 days of fertilization of grass carp eggs in order to systematically examine the role of lncRNAs and alternative splicing in fish development. We created a high-quality grass carp baseline transcriptome with a completeness of up to 93.
View Article and Find Full Text PDFDeveloping high-performance functional polymer-based electrolytes is important for realizing next generation safe lithium metal batteries. In this study, a new type of quasi-solid polymer network electrolyte (SIPH-x-y%) was prepared by combining synthesized polymer network (SIPH) containing urethane bond linked ionic liquids (ILs), polyethylene glycol (PEG), and disulfide bond moieties, lithium bis(trifluoromethanesulfonyl)imide salt (LiTFSI), and glyme type additive. It was found that SIPH-20-40% was mechanically flexible, self-healable, and showed high ionic conductivity of 2.
View Article and Find Full Text PDFIn triploid watermelon (Citrullus lanatus), the homologous chromosomes of germ cells are disorder during meiosis, resulting in the failure of seeds formation and producing seedless fruit. Therefore, mutating the genes specifically functioning in meiosis may be an alternative way to achieve seedless watermelon. REC8, as a key component of the cohesin complex in meiosis, is dramatically essential for sister chromatid cohesion and chromosome segregation.
View Article and Find Full Text PDFHerein, the synthesis of ()-α,β-unsaturated nitriles by a sequential hydroformylation/Knoevenagel reaction has been first developed. A variety of crude α-olefins from Fischer-Tropsch synthesis, internal and special olefins, as well as alkynes could be transformed into value-added alkenyl nitriles (39 examples) up to 90% yield. Remarkably, compared with commonly used tedious multistep reactions, the one-pot protocol features cheap and easily available raw materials, excellent chemo-, regio-, and stereoselectivity, very mild reaction conditions, and easy scale-up production.
View Article and Find Full Text PDFGrass carp is an important commercial fish widely cultivated in China. A wide range of temperatures, particularly extremely low temperatures, have dramatic effects on the aquaculture of this teleost. However, relatively few studies have characterized the molecular responses of grass carp exposed to acute cooling in natural environment.
View Article and Find Full Text PDFTreatment of CoCl·6HO and tris(pyrazolyl-1-yl)borate tricyanoiron(III) anions at 55 °C afforded a series of new Fe-Co polynuclear clusters: {CoCl(DMF)[(Tp)Fe(CN)]} (; Tp = hydridotris(4-methylpyrazol-1-yl)borate), (HO)@{CoCl[(Tp)Fe(CN)]} (), (MePhP){CoCl[(Tp)Fe(CN)]}·15CHCN·3CHOH·2HO (), and (BnEtN){CoCl[(Tp*)Fe(CN)]}·4CHCN·2HO (; Tp*= hydridotris(3,5-dimethylpyrazol-1-yl)borate). They feature an asymmetric [FeCo(CN)] square, a pseudocubic [FeCo(CN)] cluster, a distorted-hexagonal-prism-shaped [FeCo(CN)] cage, and a bis(trigonal-bipyramidal) cluster of [FeCo(CN)] fused at one cobalt center, respectively. The Co(II) ions adopt a four-coordinate tetrahedral geometry except for half of in an octahedral geometry.
View Article and Find Full Text PDFBackground: Grass carp (Ctenopharyngodon idellus) are important species in Asian aquaculture. A draft genome for grass carp has already been published in 2015. However, there is still a requirement for a suitable genetic linkage map to arrange scaffolds on chromosomal frameworks.
View Article and Find Full Text PDFBackground: Serum human chorionic gonadotrophin (hCG) is higher in twin than that in singleton pregnancies. As hCG stimulates the thyroid to produce more free thyroxine (FT4), which may lead to decreased thyroid-stimulating hormone (TSH) levels, the reference ranges of thyroid-related indicators may differ between singleton and twin pregnancies in the first trimester. This study aimed to establish reference ranges for thyroid-related indicators in early twin pregnancies and to compare them with singleton pregnancies.
View Article and Find Full Text PDFIntroduction: There is an unmet need for effective methods for conducting dementia prevention trials.
Methods: Home-based assessment study compared feasibility and efficiency, ability to capture change over time using in-home instruments, and ability to predict cognitive conversion using predefined triggers in a randomized clinical trial in (1) mail-in questionnaire/live telephone interviews, (2) automated telephone/interactive voice recognition, and (3) internet-based computer Kiosk technologies. Primary endpoint was defined as cognitive conversion.
A defective chemokine motif in the HIV-1 Tat protein has been hypothesized to alter central nervous system cellular trafficking and inflammation, rendering HIV-1 subtype C less neuropathogenic than B. To evaluate this hypothesis, we compared biomarkers of cellular chemotaxis and inflammation in cerebrospinal fluid (CSF) and serum in individuals infected with HIV-1 subtypes B (n = 27) and C (n = 25) from Curitiba, Brazil. None had opportunistic infections.
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