Publications by authors named "Yanxia Peng"
Article Synopsis
- Methamphetamine (MA) is a widely abused stimulant that causes neurotoxicity through oxidative stress and apoptosis, particularly affecting dopaminergic neurons.
- The study investigated how MA influences various proteins related to neuroprotection (Nrf2), mitochondrial dynamics (Mfn1, Drp1), and apoptosis (Caspase 3) in brain tissue of MA users and a rat model.
- Results showed that levels of Nrf2 and Mfn1 decreased while levels of Drp1, Cyt-c, and Caspase 3 increased in MA users, suggesting that Nrf2 may be crucial in mediating the harmful effects of MA on neurons through oxidative stress and mitochondrial dysfunction.
Background: Postpartum depression (PPD) is among the most common postpartum complications. Its prevalence is associated with strong regional variability. Women in rural areas of China have a high risk of PPD.
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- Methamphetamine (MA) abuse leads to serious cardiovascular issues, making myocardial injury and oxidative stress key concerns, with the Nrf2 pathway playing a crucial role in these processes.
- In an experiment, MA was administered to mice, resulting in significant increases in markers of cardiac injury and oxidative stress, highlighting the harmful effects of MA on the heart.
- Activation of the Nrf2 pathway reduced the damage caused by MA, while knocking out Nrf2 worsened the injury, indicating that Nrf2 has a protective role against MA-induced heart damage.
Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely abused drugs worldwide. The continuous use of METH eventually leads to neurotoxicity and drug addiction. Studies have shown that neurotoxicity is strongly associated with METH-induced neuroinflammation, and microglia are the key drivers of neuroinflammation.
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- - The study focuses on the combined abuse of methamphetamine (MA) and ketamine (KET), highlighting a lack of research into the mechanisms behind their combined addiction.
- - A rat model was used to assess the roles of various neurotransmitters and receptors (dopamine, serotonin, MAO, GluR1, GluR2) related to MA and KET addiction, using techniques like ELISA and western blotting.
- - Results indicate that both drugs can induce a conditioned place preference (CPP) in rats, with KET enhancing this effect and affecting the levels of specific neurotransmitters, suggesting a complex role of KET in MA addiction that can be both addictive and anti-addictive.
Parkinson's disease occurs due to loss of dopaminergic neurons, which alters the behavioural changes. The present study evaluates the effect of exercise on neurodegeneration against Parkinson's disease (PD) rat model and postulates its effect on novel molecular pathway. Rotenone was administered at 1 mg/kg s.
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- * A survey conducted between September 2021 and June 2022 revealed that anxiety levels, physical activity, and sleep disorders among pregnant women showed no significant differences between those affected by the policy and those who were not.
- * Dietary habits changed, with women under the policy consuming more fruit, but also less protein-rich foods like aquatic products and eggs, indicating overall poor compliance with dietary guidelines for pregnant women.
6-Gingerol, the main active ingredient in ginger, exhibits a variety of biological activities, such as antioxidant, anti-inflammatory, and anticancer activities, and can affect cell development. However, the effects of 6-gingerol on mammalian reproductive processes, especially early embryonic development, are unclear. This study explored whether 6-gingerol can be used to improve the quality of in vitro-cultured porcine embryos.
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- The text mentions a correction to a previously published article identified by the DOI 10.1016/j.jgr.2021.07.005.
- It indicates that there were inaccuracies or errors in that article that needed to be addressed.
- Such corrections are important for maintaining the integrity of scientific literature and ensuring accurate information for future research.
Background: Methamphetamine (MA) abuse is a major global public health problem. However, it is not yet known whether cannabidiol (CBD) has protective effects on MA-induced cardiotoxicity. The present study investigated whether CBD has protective effects on MA-induced cardiac damage in rats via the protein kinase A/cyclic adenosine monophosphate (cAMP)-response element-binding protein (PKA/CREB) pathway.
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- Methamphetamine (METH) abuse has rapidly increased in recent years, leading to severe addiction and neurotoxicity, with no approved treatments currently available.
- Cannabidiol (CBD), a non-psychoactive compound from cannabis, shows promise in protecting against METH's harmful effects by counteracting neurotoxic mechanisms, though its exact action is still unclear.
- Research indicates that CBD and METH may bind to the dopamine receptor D1 (DRD1), with CBD potentially blocking METH's damaging impacts on cell signaling and apoptosis, offering insight into a possible therapeutic strategy for METH use disorders.
Article Synopsis
- This study explores how ginsenoside Rb1 (GsRb1) impacts methamphetamine (METH) toxicity in neuroblastoma cells and METH-related behavior in rats.
- Researchers investigated GsRb1's role in regulating specific signaling pathways (NR2B/ERK/CREB/BDNF) that are affected by METH exposure.
- Findings indicate that GsRb1 improves cell viability, reduces negative METH-induced effects, and may serve as a potential treatment for METH toxicity and addiction.
Article Synopsis
- KRAS is a proto-oncogene that encodes a protein involved in various cellular functions like cytokine secretion and cell survival, but its role in preadipocyte differentiation and lipid accumulation was previously unclear.
- A study analyzed KRAS inhibition in specific cell lines (3T3-L1 and C2C12) and found that it affects key proteins related to cell growth and fat storage, reducing cell proliferation while promoting differentiation into mature fat cells.
- Inhibition of KRAS also decreased the activation of several signaling pathways during differentiation, highlighting its unique role in regulating cell behavior related to fat formation and lipid storage.
Article Synopsis
- Schisanhenol (SAL), derived from Schisandra plants, has shown various biological activities but its effects on the female reproductive system are not well understood.
- Previous research indicated SAL has antioxidant properties, leading to the hypothesis that it could enhance porcine embryo development by reducing oxidative stress.
- The study found that 10 μM SAL improved blastocyst formation rates and mitochondrial activity while decreasing reactive oxygen species (ROS) and apoptosis, alongside downregulating MAPK pathway phosphorylation levels.
Carnosic acid (CA), a natural catechol rosin diterpene, is used as an additive in animal feeds and human foods. However, the effects of CA on mammalian reproductive processes, especially early embryonic development, are unclear. In this study, we added CA to parthenogenetically activated porcine embryos in an in vitro culture medium to explore the influence of CA on apoptosis, proliferation, blastocyst formation, reactive oxygen species (ROS) levels, glutathione (GSH) levels, mitochondrial membrane potential, and embryonic development-related gene expression.
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- * Significant findings include higher frequencies of certain B-cell subsets, such as hematopoietic stem cells and naïve B-cells, in SLE patients compared to controls, along with specific correlations with factors like serum cholesterol and disease severity (SLEDAI score).
- * The research suggests that understanding the variations in B-cell subsets can enhance our knowledge of SLE's mechanisms and potentially inform future treatment strategies.
Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is a member of the Cytoplasmic polyadenylation element-binding family, which has been found to regulate the translation of dormant and masked mRNA in Xenopus oocytes and plays potential roles in regulating biological functions in cells and tissues. However, its role in cumulus cells is not clear. In this study, the mRNA expression of CPEB3 in bovine cumulus cells was inhibited with small interfering RNA.
View Article and Find Full Text PDFObjective: To observe the effect of electroacupuncture (EA) on diaphragmatic function based on conventional treatment in patients with poststroke tracheotomy tube.
Methods: A total of 70 patients were randomized into an observation group (35 cases) and a control group (34 cases, 1 case dropped off). Internal medical basic treatment and breathing training were given in both groups.
Article Synopsis
- Imperatorin (IMP) is a furanocoumarin with various pharmacological benefits, and this study investigates its impact on early pig embryo development and underlying mechanisms.* -
- Results indicated that adding 40 μM IMP to the culture medium improved blastocyst rates, total cell numbers, and reduced apoptosis in embryos, alongside encouraging gene expression related to pluripotency.* -
- IMP also decreased reactive oxygen species (ROS), enhanced mitochondrial activity, and inhibited autophagy, suggesting it helps promote healthy preimplantation embryo development by minimizing oxidative stress.*
Article Synopsis
- The study aimed to evaluate the effects of "Tongyuan" acupuncture on cough reflex, pulmonary infections, and swallowing function in stroke patients who had undergone tracheotomy.
- Seventy-four patients were split into two groups: one receiving Tongyuan acupuncture and the other receiving scalp acupuncture, alongside standard treatments over a four-week period.
- Results showed significant improvements in cough reflex and pulmonary infection scores for both groups, indicating that acupuncture treatments could enhance recovery in these areas.
Article Synopsis
- The study investigates the role of collagen type I alpha 1 chain (COL1A1) in bovine cumulus cells, focusing on its effects on cell behavior and function.
- After inhibiting COL1A1 using siRNA, researchers observed significant reductions in cell proliferation, cholesterol synthesis, and increases in apoptosis, along with altered cell cycle dynamics.
- The findings suggest that COL1A1 is crucial for maintaining normal function in bovine cumulus cells, as its inhibition leads to heightened reactive oxygen species levels and disrupted cellular processes.
Objective: An experiment was conducted to determine the effects of L-arginine (L-Arg) and N-carbamoylglutamic acid (NCG) on the growth, metabolism, immunity and community of cecal bacterial flora of weanling and young rabbits.
Methods: Eighteen normal-grade male weanling Japanese White Rabbits (JWR) were selected and randomly divided into 6 groups with or without L-Arg and NCG supplementation. The whole feeding process was divided into weanling stage (Day 37 to 65) and young stage (Day 66 to 85).
Article Synopsis
- Recent research indicates that SNPs in miRNA promoters can affect disease susceptibility, specifically breast cancer.
- The study focused on two SNPs, rs10877887 and rs13293512, assessing their association with breast cancer risk using DNA samples from 301 patients and 310 controls.
- Findings revealed that the rs13293512 CC genotype is linked to a higher breast cancer risk, particularly in patients with negative hormone receptors and early-stage cancer, suggesting it may serve as a potential biomarker for breast cancer in Chinese women.
Article Synopsis
- * Involving 205 women, the researchers computed multiple features from breast lesions and used a novel classification model for analysis, resulting in malignant lesions showing lower mean apparent diffusion coefficient (ADC) values.
- * The incorporation of these combined features into a multivariate model significantly improved diagnostic accuracy, achieving an average accuracy of 0.90 when ADC values were included alongside morphology and kinetic features.
Article Synopsis
- - The study developed a new test strip method for detecting Norovirus GI and GII using fluorescent particles and specific antibodies, improving the detection process.
- - The tested method demonstrated significantly higher sensitivity (4 to 8 times) compared to a reference method while effectively avoiding cross-reactivity with rotavirus.
- - Follow-up testing confirmed that most specimens initially categorized differently by the two methods aligned with the tested method's results, indicating its strong performance in detecting Norovirus infections.