Publications by authors named "Yanxia Chang"
Article Synopsis
- * Two main evolutionary patterns identified in T-ALL are "clonal shift," where new clones emerge, and "clonal drift," where existing clones continue to evolve.
- * The RNA-binding protein MSI2 was found to be significantly upregulated in persistent TCR clonotypes at relapse, suggesting it plays a role in tumor growth and chemotherapy resistance, making it a potential new target for treatment.
Objectives: The aim of this study is to profile the transcriptional landscapes of affected tissues and peripheral blood mononuclear cells (PBMCs) at the single-cell level in IgG4-related disease (IgG4-RD). Identifying the cell populations and crosstalk between immune cells and non-immune cells will assist us in understanding the aetiology of IgG4-RD.
Methods: We performed single-cell RNA sequencing analysis on submandibular glands (SMGs) and PBMCs from patients with IgG4-RD and matched controls.
Acquired aplastic anemia (AA) is recognized as an immune-mediated disorder resulting from active destruction of hematopoietic cells in bone marrow (BM) by effector T lymphocytes. Bulk genomic landscape analysis and transcriptomic profiling have contributed to a better understanding of the recurrent cytogenetic abnormalities and immunologic cues associated with the onset of hematopoietic destruction. However, the functional mechanistic determinants underlying the complexity of heterogeneous T lymphocyte populations as well as their correlation with clinical outcomes remain to be elucidated.
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- Minimal residual disease (MRD) after chemotherapy is a key indicator for predicting outcomes in cancers, but understanding its resistance mechanisms is challenging due to the rarity and variety of these residual cells.
- Researchers conducted a study analyzing over 161,000 single-cell transcriptomes to examine changes in B-cell acute lymphoblastic leukaemia (B-ALL) from diagnosis to relapse and residual states.
- They found that relapse leukaemic cells often became less differentiated, and residual cells activated a hypoxia pathway, which when inhibited, made the leukaemic cells more responsive to chemotherapy, offering new treatment possibilities for B-ALL.
Two phenolic compound parameters (total phenolic and flavonoid contents) and 5 antioxidant parameters (DPPH [2, 2-diphenyl-1-picrylhydrazyl] radical scavenging activity, HRSC (hydroxyl radical scavenging capacity), FRAP (ferric ion reducing antioxidant power), CUPRAC (cupric ion reducing antioxidant capacity), and MCA (metal chelating activity) were measured in bulbs and bolts of 43 garlic cultivars. The bulbs of cultivar '74-x' had the highest phenolic content (total phenolic, flavonoids) and the strongest antioxidant capacity (DPPH, FRAP, and CUPRAC), followed by bulbs of cultivar 'Hanzhong purple'; the bulbs of cultivar 'Gailiang' had the lowest phenolic content and antioxidant capacity (FRAP, CUPRAC, MCA). The bolts of 'Hanzhong purple' also had higher phenolic content.
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