Differential Signal-Amplitude-Modulated Multi-Beam Remote Optical Touch Based on Grating Antenna.

As screen sizes are becoming larger and larger, exceeding human physical limitations for direct interaction via touching, remote control is inevitable. However, among the current solutions, inertial gyroscopes are susceptible to positional inaccuracies, and gesture recognition is limited by cameras' focus depths and viewing angles. Provided that the issue of ghost points can be effectively addressed, grating antenna light-trapping technology is an ideal candidate for multipoint inputs.

GPX4 allosteric activators inhibit ferroptosis and exert myocardial protection in doxorubicin-induced myocardial injury mouse model.

Ferroptosis is a unique type of non-apoptotic form of cell death characterized by increased lipid hydroperoxide levels. It has relevance for a number of pathological conditions including multiple organ injuries and degenerative diseases. GPX4 plays an important role in ferroptosis by repairing lipid hydroperoxides.

Aberrant concordance among dynamics of spontaneous brain activity in patients with migraine without aura: A multivariate pattern analysis study.

Background: Alterations in the static and dynamic characteristics of spontaneous brain activity have been extensively studied to investigate functional brain changes in migraine without aura (MwoA). However, alterations in concordance among the dynamics of spontaneous brain activity in MwoA remain largely unknown. This study aimed to determine the possibilities of diagnosis based on the concordance indices.

Altered effective connectivity from cerebellum to motor cortex in chronic low back pain: A multivariate pattern analysis and spectral dynamic causal modeling study.

To explore the central processing mechanism of pain perception in chronic low back pain (cLBP) using multi-voxel pattern analysis (MVPA) based on the static and dynamic fractional amplitude of low-frequency fluctuations (fALFF) analysis, and spectral dynamic causal modeling (spDCM). Thirty-two patients with cLBP and 29 matched healthy controls (HCs) for the first cohort and 24 patients with cLBP and 22 HCs for the validation cohort underwent resting-state fMRI scan. The alterations in static and dynamic fALFF were as classification features to distinguish patients with cLBP from HCs.

Paleo-Geomorphology Determines Spatial Variability of Geogenic Ammonium Concentration in Quaternary Aquifers.

Naturally occurring (i.e., geogenic) ammonium in groundwater has been widely detected globally, but the major controls on its regional distribution have been poorly characterized.

Enrichment of geogenic phosphorus in a coastal groundwater system: New insights from dissolved organic matter characterization.

High concentrations of geogenic phosphorus (P) in coastal aquifer systems pose a serious and continuous threat to the health of marine ecosystems. A major source for geogenic P enrichment in aquifer systems is the mineralization of P-containing organic matter. However, the mechanisms that drive the enrichment remain unclear.

A true response of the brain network during electroacupuncture stimulation at scalp acupoints: An fMRI with simultaneous EAS study.

Objectives: The aim of this study was to explore simultaneous brain network responses to electroacupuncture stimulation (EAS) at scalp acupoints by accounting for placebo effects.

Materials And Methods: Sixty healthy subjects were recruited and randomly divided into two groups: Group 1 and Group 2. Functional magnetic resonance imaging (fMRI) was performed in Group 1 with sham acupuncture stimulation at acupoints Shenting (GV24) and Touwei (ST8) without EAS.

The cumulative therapeutic effect of acupuncture in patients with migraine without aura: Evidence from dynamic alterations of intrinsic brain activity and effective connectivity.

We explored the dynamic alterations of intrinsic brain activity and effective connectivity after acupuncture treatment to investigate the underlying neurological mechanism of acupuncture treatment in patients with migraine without aura (MwoA). The Functional Magnetic Resonance Imaging (fMRI) scans were separately obtained at baseline, after the first and 12th acupuncture sessions in 40 patients with MwoA. Compared with the healthy controls (HCs), patients with MwoA mostly showed a decreased dynamic amplitude of low-frequency fluctuation (dALFF) variability in the rostral ventromedial medulla (RVM), superior lobe of left cerebellum (Cerebellum_Crus1_L), right precuneus (PCUN.

Ultrafast liquid chromatography-tandem mass spectrometry determination of donepezil in human plasma: application to a bioequivalence study.

A liquid chromatography equipped with tandem mass spectrometric method using multi-stage flow rates was developed for the determination of donepezil in human plasma to support a randomized, crossover bioequivalence (BE) study in which healthy volunteers each received a single oral dose of the reference and test formulations of 10 mg donepezil hydrochloride. This integrated liquid chromatography with tandem mass spectrometry (LC-MS/MS) system with electrospray ionization and a deuterium-labeled internal standard (IS) were employed for the positive multiple-reaction-monitoring (MRM) analyses. The baseline separation using a high-resolution monolithic column under gradient and flexible flowrate conditions between donepezil and multiple interfering peaks from the extracted quality control, calibration standard and study plasma samples following simple protein precipitation extraction procedures was accomplished within 1.

The Changes of Brain Function After Spinal Manipulation Therapy in Patients with Chronic Low Back Pain: A Rest BOLD fMRI Study.

Objective: To investigate the changes of regional homogeneity (Reho) values before and after spinal manipulative therapy (SMT) in patients with chronic low back pain (CLBP) through rest blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI).

Methods: Patients with CLBP (Group 1, n = 20) and healthy control subjects (Group 2, n = 20) were recruited. The fMRI was performed three times in Group 1 before SMT (time point 1, TP1), after the first SMT (time point 2, TP2), after the sixth SMT (time point 3, TP3), and for one time in Group 2, which received no intervention.

2-μm fused-core column ultra-high-performance liquid chromatography/tandem mass spectrometric determination of donepezil in human plasma: Application to a bioequivalence study.

Ultra-high-performance liquid chromatography (UHPLC) hyphenated to tandem mass spectrometric methods using the dimethylpentafluorophenylpropyl stationary phase with polar and nonpolar characteristics of a 2-μm fused-core silica particle packing were evaluated to perform efficient separation for the analysis of donepezil in human plasma. The fused-core silica particle design providing the shorter diffusional mass transfer path for the analytes is less affected in resolving power by increasing mobile-phase velocity for faster chromatographic resolution between the administered compound and multiple interfering peaks from the extracted quality control, calibration standard and study samples following simple protein precipitation extraction procedures. In this work, two UHPLC-MS/MS approaches requiring 1.

Novel Insights into Dissolved Organic Matter Processing Pathways in a Coastal Confined Aquifer System with the Highest Known Concentration of Geogenic Ammonium.

High levels of geogenic ammonium in groundwater is a highly neglected nitrogen pool in coastal aquatic systems. Although organic matter (OM) mineralization is known to significantly influence geogenic ammonium enrichment, the detailed mechanism underlying ammonium enrichment based on dissolved organic matter (DOM) characterization in coastal aquifer systems remains unclear. In this study, we characterized the optical and molecular signatures of DOM coupled with hydrogeochemistry and multiple isotopes (H/O/C/N) to elucidate in detail the mechanisms underlying the anomalously high ammonium in the coastal confined aquifer system of the Pearl River Delta, which exhibits the highest reported geogenic ammonium concentration in groundwater on the Earth.

Electroacupuncture Synergistically Inhibits Proinflammatory Cytokine Production and Improves Cognitive Function in Rats with Cognitive Impairment due to Hepatic Encephalopathy through p38MAPK/STAT3 and TLR4/NF-B Signaling Pathways.

Objective: To investigate the effect of electroacupuncture (EA) on cognitive dysfunction in rats with hepatic encephalopathy and its underlying mechanism.

Methods: Fifty Wistar rats were randomly divided into a normal group ( = 10) and model group ( = 40). Rat models of hepatic encephalopathy were established by administration of carbon tetrachloride and thioacetamide for a total of 12 weeks.

Performance of a Flexible 12-Channel Head Coil in Comparison to Commercial 16- And 24-Channel Rigid Head Coils.

Purpose: To compare the performance of a 12-channel flexible head coil (HFC12) with commercial 16-channel (HRC16) and 24-channel (HRC24) rigid coils.

Methods: The phantom study was performed on a 1.5 T MR scanner with HFC12, HRC16, and HRC24.

Dissolved organic matter characterization in high and low ammonium groundwater of Dongting Plain, central China.

High levels of ammonium in groundwater is a potential threat to drinking water security and ecological status. The role of dissolved organic matter (DOM) in mobilization of natural ammonium in groundwater is crucial but the intrinsic link between them has still been poorly understood. This study used high-pressure size exclusion chromatography (HPSEC) and fluorescence excitataion-emission-matrix spectra (EEMs) with parallel factor analysis (PARAFAC) to elucidate the influence of DOM characteristics in groundwater systems having contrastive ammonium levels in Dongting Plain, central Yangtze River.

Spinal Manipulative Therapy Alters Brain Activity in Patients With Chronic Low Back Pain: A Longitudinal Brain fMRI Study.

Spinal manipulative therapy (SMT) helps to reduce chronic low back pain (cLBP). However, the underlying mechanism of pain relief and the neurological response to SMT remains unclear. We utilized brain functional magnetic resonance imaging (fMRI) upon the application of a real-time spot pressure mechanical stimulus to assess the effects of SMT on patients with cLBP.

Enrichment of Geogenic Ammonium in Quaternary Alluvial-Lacustrine Aquifer Systems: Evidence from Carbon Isotopes and DOM Characteristics.

Geogenic ammonium in groundwater owing to mineralization of natural organic matter (NOM) has been reported in different geologic settings, but detailed mechanisms responsible for high ammonium concentration levels are poorly understood. To this end, we chose Quaternary high ammonium aquifer systems in central Yangtze River basins and used carbon isotopes in both dissolved organic carbon and inorganic carbon together with characterization of dissolved organic matter (DOM) and groundwater chemistry to reveal mechanisms related to the genesis of ammonium. The results indicate that high levels of geogenic ammonium (up to 33.

Prediction of nodal involvement in primary rectal carcinoma without invasion to pelvic structures: accuracy of preoperative CT, MR, and DWIBS assessments relative to histopathologic findings.

Objective: To investigate the accuracy of preoperative computed tomography (CT), magnetic resonance (MR) imaging and diffusion-weighted imaging with background body signal suppression (DWIBS) in the prediction of nodal involvement in primary rectal carcinoma patients in the absence of tumor invasion into pelvic structures.

Methods And Materials: Fifty-two subjects with primary rectal cancer were preoperatively assessed by CT and MRI at 1.5 T with a phased-array coil.

[Chlorophyll content nondestructive measurement method based on Vis/NIR spectroscopy].

In the present paper a method based on Vis/NIR spectral analysis technology was applied to the nondestructive measurement of plant chlorophyll content. Firstly, the Vis/NIR spectra in the wavelength range from 500 to 900 nm of the plant leaves were acquired from 35 samples by transmittance and reflectance method, and then three different mathematical treatments were used in original spectra data pretreatment to decrease the noise: moving average smoothing with the segment size 5, first Savitzky-Golay derivative, and wavelet transform (WT) way. Secondly, a total of 35 samples were examined in the test, in which 23 samples were selected randomly for model building and the other 12 for model prediction, then partial least squares (PLS) method was used to develop the quantitative analysis model for chlorophyll content with absorbance spectroscopy, and 7 principal components (PCs) were selected.

Spontaneous formation of Ag nanoparticles in dimethylacetamide solution of poly(ethylene glycol).

The spontaneous formation of Ag nanoparticles in a dimethylacetamide (DMAC) solution of poly(ethylene glycol) (PEG) was studied. FTIR analysis showed the formation of carbonyl groups, revealing that PEG acted as not only a protective agent but also a reducing agent in the formation of Ag nanoparticles. Since no significant reactions were observed when poly(tetramethylene glycol) (PTMG) was used to replace PEG or acetonitrile was used to replace DMAC, it was suggested that PEG molecules might be coiled to form pseudo-crown ether cavities, in which Ag complexes were bound to the oxyethylene groups and reduced, and that the use of a solvent which might appropriately solvate the Ag salt was important for the formation of Ag nanoparticles.