Publications by authors named "Yanuar Setiadi"
Article Synopsis
- The translocator protein 18-kDa (TSPO) is a crucial mitochondrial membrane protein linked to various biological processes, including cancer development and progression.
- Increased expression of TSPO in cancer cells is associated with aggressive cancer types and poor prognosis, highlighting its potential as a target for diagnostic and prognostic tools.
- Recent advancements in hybrid imaging probes that combine radioactive and fluorescent molecules show promise for enhancing the effectiveness of image-guided surgery in cancer treatment, although further development and application are needed.
We synthesised and biologically evaluated two new hybrid probes and which were built from three structural entities: benzothiazole-phenyl, fluorescein isothiocyanate (FITC), and iodine-131. These probes were designed for potential applications in assisting surgical procedures of solid cancers. The cytotoxicity study demonstrated that fluorescent probes (31.
View Article and Find Full Text PDFFluorescence image-guided surgery (FIGS) can serve as a tool to achieve successful resection of tumour tissues during surgery, serving as a surgical navigator for surgeons. FIGS relies on the use of fluorescent molecules that can specifically interact with cancer cells. In this work, we developed a new model of fluorescent probe based on benzothiazole-phenylamide moiety featuring the visible fluorophore nitrobenzoxadiazole (NBD), namely BPN-01.
View Article and Find Full Text PDFArticle Synopsis
- COVID-19 has significantly impacted global health and economies, with over 5.3 million deaths reported by December 2021, highlighting the need for effective treatments beyond vaccines.
- This study explores chicken egg yolk antibodies (IgY) targeting the SARS-CoV-2 spike protein as a potential way to neutralize the virus for passive immunization.
- Preclinical results indicate that IgY can specifically bind to virus-related antigens and safely accumulate in the trachea of mice, suggesting its promise as an intranasal treatment against COVID-19.