A Retrospective Data Audit of Outcome of Moderate and Severe Covid-19 Patients Who Had Received MP and Dex: A Single Center Study.

Purpose: To evaluate the necessity of the application of glucocorticoid (GC) in moderate COVID-19 patients, and which is the optimal choice between methylprednisolone (MP) and dexamethasone (DEX) in the clinical use of GC in different types of COVID-19 patients.

Patients And Methods: The study included patients with COVID-19 in Shanxi, China, from December 18, 2022, to March 1, 2023. The main clinical outcomes were 30-day mortality, disease exacerbations, and hospitalization days.

TESMIN is a Prognostic Biomarker Associated with Immunosuppression and Activated Cell Cycle in Lung Adenocarcinoma.

Background: The Testis Expressed Metallothionein Like Protein (TESMIN) gene encodes highly conserved, cysteine-rich, low-molecular proteins that are activated by and have an affinity for heavy metal ions. Previous literature has shown its association with cancer. Nevertheless, no thorough bioinformatics analysis of TESMIN has been done yet in lung adenocarcinoma (LUAD).

CCN1 inhibition affects the function of endothelial progenitor cells under high-glucose condition.

Background: The impact of cysteine-rich angiogenic inducer 61 (Cyr61, also called CCN1) on endothelial progenitor cells (EPCs) from diabetic-rat-derived whole peripheral and bone marrow remains poorly understood. Therefore, the expression levels of CCN1, CCN1-induced C-X-C chemokine receptor type 4 (CXCR4), and stromal-cell-derived factor-1 (SDF-1) were explored under high glucose (HG) conditions.

Objectives: The aim of the study was to explore the effects of high CCN1 levels on EPC activity in diabetic rats through mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway modulation.

Repeated pulmonary nodules as the primary symptom of familial hemophagocytic lymphohistiocytosis in adults: a case report and review.

Pulmonary nodules are usually considered to be associated with malignant tumors and benign lesions, such as granuloma, pulmonary lymph nodes, fibrosis, and inflammatory lesions. Clinical cases of pulmonary nodules associated with hemophagocytic lymphohistiocytosis have rarely been reported. Therefore, when patients develop pulmonary nodules, the possibility of developing hemophagocytic lymphohistiocytosis is often not considered.

Exploration and Validation of Potential Biomarkers and Therapeutic Targets in Ferroptosis of Asthma.

Purpose: Asthma is a chronic inflammatory airway disease involving multiple mechanisms, of which ferroptosis is a form of programmed cell death. Recent studies have shown that ferroptosis may play a crucial role in the pathogenesis of asthma, but no specific ferroptosis gene has been found in asthma, and the exact mechanism is still unclear. The present study aimed to screen ferroptosis genes associated with asthma and find therapeutic targets, in order to contribute a new clue for the diagnosis and therapy of asthma.

Predictors of COVID-19 Severity in Elderly Patients Infected by Omicron in China, 18 December 2022-5 February 2023.

Purpose: To analyze the clinical characteristics and prognosis of patients hospitalized with non-severe, severe pneumonia and death in Omicron COVID-19.

Patients And Methods: We collected clinical data from 118 patients with COVID-19 in China from 18 December, 2022 and 5 February, 2023. According to the outcome, the patients were divided into non-severe group, severe group and death group.

Roles of catalytic ozonation by bimetallic Fe/Ce loading sludge-derived biochar in amelioration of sludge dewaterability: Performance and implementation mechanisms.

In this study, an environmentally friendly alternative was developed using catalytic ozonation by sludge-derived biochar loaded with bimetallic Fe/Ce (O/SBC-FeCe) for enhanced sludge dewatering. The results indicated that the lowest capillary suction time (CST) of 20.9 s and water content of dewatered sludge cake (Wc) of 64.

A novel conditioning approach for amelioration of sludge dewaterability using activated carbon strengthening electrochemical oxidation and realized mechanism.

Sludge dewatering is an essential process for reduction of sludge volume to decrease cost of ultimate disposal. In this study, a novel method using activated carbon (AC) strengthening electrochemical (EC) treatment (EC/AC) was adopted to improve greatly sludge dewaterability. It was shown that capillary suction time (CST) and water content of dewatered sludge cake (Wc) were reduced to 55.

Polyhexamethylene biguanidine used as a new type sewage sludge conditioning agent: Effect on sludge dewaterability and mechanism.

Dewatering is the basic procedure of sludge treatment and disposal, and environmentally friendly and efficient sludge conditioning methods are urgently needed. Polyhexamethylene biguanide (PHMB), a broad-spectrum germicide used in daily life and medicine, was proposed as a sludge conditioning reagent in this paper, and its effect on waste activated sludge (WAS) dewaterability was studied for the first time. Results showed that PHMB can improve sludge dewatering performance, and capillary suction time (CST) and water content (Wc) of dewatered sludge cake was reduced by 78.

A comprehensive study on simultaneous enhancement of sludge dewaterability and elimination of polycyclic aromatic hydrocarbons by Fe catalyzing O process.

Simultaneous removal of polycyclic aromatic hydrocarbons (PAHs) in the process of enhancement of sludge dewaterability via oxidation of hydroxyl radicals (•OH) and flocculation of Fe by Fe-catalyzing O were investigated as a novel research focus. The results showed that capillary suction time (CST) and water content of dewatered sludge cake (Wc) were reduced from 57.9 s and 85.

Enhanced waste activated sludge dewaterability by the ozone-peroxymonosulfate oxidation process: Performance, sludge characteristics, and implication.

Dewatering treatment is an essential step to diminish sludge volume, cut down transportation costs, and improve subsequent disposal efficiency. In this study, ozone-peroxymonosulfate (O/PMS) oxidation process was employed to ameliorate sludge dewaterability. Sludge capillary suction time (CST) and water content (Wc) of dewatered sludge cake could reduce from 70.

Insight into the roles of electrolysis-activated persulfate oxidation in the waste activated sludge dewaterability: Effects and mechanism.

Sludge dewatering, as one of the most important steps of sludge treatment, can facilitate transportation and improve disposal efficiency by reducing the volume of sludge. This study investigated the effects of electrolysis-activated persulfate oxidation on improving sludge dewaterability. The results indicated that the sludge capillary suction time (CST) and water content of dewatered sludge cake (Wc) reduced from 93.

C-reactive protein and thyroid-stimulating hormone levels as risk factors for hypothyroidism in patients with subacute thyroiditis.

Objective: This study was designed to explore the relationships between the clinical characteristics and outcomes of patients with subacute thyroiditis (SAT).

Design: This is a single-center retrospective study.

Patients: Eighty-nine patients with SAT who were hospitalized in the Sir Run Run Shaw Hospital in Zhejiang, China, from October 2014 to September 2020 were included.

Insights into the enhancement of waste activated sludge dewaterability using sodium dichloroisocyanurate and dodecyl dimethyl ammonium chloride: Performance, mechanism, and implication.

Sludge dewatering is essential for reduction of sludge volume to cut the cost of transportation and disposal. Combined application of sodium dichloroisocyanurate (DCCNa) and dodecyl dimethyl ammonium chloride (DDAC) was attempted to promote sludge dewatering performance and physicochemical properties for the first time in this work. The results showed that capillary suction time (CST) and moisture content of dewatered sludge cake (Mc) decreased to 15.

Perioperative safety and feasibility outcomes of stage IIIA-N2 non-small cell lung cancer following neoadjuvant immunotherapy or neoadjuvant chemotherapy: a retrospective study.

Background: We sought to determine the perioperative safety and feasibility outcomes of stage IIIA (N2) non-small cell lung cancer (NSCLC) following neoadjuvant immunotherapy or neoadjuvant chemotherapy.

Methods: The clinical details of patients who attended the Affiliated Hospital of Qingdao University between January 2019 and December 2020 were retrospectively evaluated. Eligible patients had pathologically proven stage IIIA (N2) NSCLC and were randomly prescribed neoadjuvant therapy.

circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p.

Background: As a type of non-coding RNA, circular RNAs (circRNAs) are considered to be functional molecules associated with human cancers. An increasing number of circRNAs have been verified in malignant progression in a number of cancers. The circRNA, circFBXW7, has been proven to play an important role in tumor proliferation and metastasis.

Circ-AASDH functions as the progression of early stage lung adenocarcinoma by targeting miR-140-3p to activate E2F7 expression.

Background: Lung adenocarcinoma (LUAD), which is the most common subtype of non-small cell lung cancer, is a leading course of cancer-related mortality worldwide. Recently, circular RNA (CircRNAs) has become a hot spot in cancer research because of its important role in tumorigenesis and development and its superior stability. This study aims to clarify the role of circ-AASDH in LUAD and explore its competitive endogenous RNA mechanism.

A sodium dichloroisocyanurate-based conditioning process for the improvement of sludge dewaterability and mechanism studies.

Sludge dewatering is necessary to reduce the volume of sludge for cost-effective transport and ultimate disposal. In this study, a novel combined chemical conditioning process was proposed to improve sludge dewatering performance in which sludge flocs were destructed by sodium dichloroisocyanurate (DCCNa) and re-flocculated by Al(SO) and the mechanism was elucidated. The results showed that sludge capillary suction time (CST) dropped to 15.

Enhancement of waste activated sludge dewaterability by ultrasound-activated persulfate oxidation: Operation condition, sludge properties, and mechanisms.

The study proposed the ultrasound-activated persulfate oxidation as a novel approach to enhance sludge dewaterability. The results demonstrated that the reduction of water content of dewatered sludge cake was 16.5% and the capillary suction time was reduced to 39.

Desmoglein 3 and Keratin 14 for Distinguishing Between Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.

Background: Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are the leading major histological phenotypes of all non-small cell lung cancer (NSCLC). In this study, the candidate genes and the potential tumorigenesis distinguishing between LUAD and LUSC were analyzed.

Methods: The present study investigated two microarray datasets (GSE28571 and GSE10245) downloaded from the Gene Expression Omnibus (GEO) database.

First-Line Immune-Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Current Landscape and Future Progress.

Lung cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. Most of these patients with non-small cell lung cancer (NSCLC) present with the advanced stage of the disease at the time of diagnosis, and thus decrease the 5-year survival rate to about 5%. Immune checkpoint inhibitors (ICIs) can act on the inhibitory pathway of cancer immune response, thereby restoring and maintaining anti-tumor immunity.

1α, 25-dihydroxyvitamin D3 inhibits transforming growth factor β1-induced epithelial-mesenchymal transition via β-catenin pathway.

Background: The transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) has been proven associated with the pathogenesis of asthmatic airway remodeling, in which the Wnt/β-catenin pathway plays an important role, notably with regard to TGF-β1. Recent studies have shown that 1α, 25-dihydroxyvitamin D3(1α, 25(OH)2D3) inhibits TGF-β1-induced EMT, although the underlying mechanism have not yet been fully elucidated.

Methods: Alveolar epithelial cells were exposed to 1α, 25(OH)2D3, ICG-001, or a combination of both, followed by stimulation with TGF-β1.

A novel Fe/persulfate/tannic acid process with strengthened efficacy on enhancing waste activated sludge dewaterability and mechanism insight.

As an essential section before final sludge disposal, sludge dewatering has currently been one of the focus issues. In this study, an innovative Fe/persulfate/tannic acid (TA) process was verified to further strengthen systemic efficacy on enhancing sludge dewaterability, compared with the conventional Fe/persulfate process. With the efficient TA/Fe (molar ratio) of 0.

Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects.

Abnormal development of central nervous system (CNS) caused by neural tube defects (NTDs) is not only remained the major contributor in the prevalence of stillbirths and neonatal deaths, but also represents a significant cause of lifelong physical disability in the surviving infants. Ethionine is a non-proteinogenic amino acid and antagonist of methionine. Methionine cycle is essential for the elimination of reactive oxygen species (ROS), while lysosomes are involved in the initiation of autophagy.

Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression.

Background: Circular RNAs (circRNAs) belong to a new type of endogenous non-coding RNA and plays a key role in carcinogenesis. Circ-ZKSCAN1 (hsa_circ_0001727) has been proven to be a tumor-dependent circRNA. However, its role in non-small cell lung cancer (NSCLC) has been underreported.