Adhesives That Contains Ionic Liquids Segment: From Synthesis to Applications.

As technology has developed by leaps and bounds over decades, the development of high-performance supramolecular adhesives has become crucial in both scientific and industrial fields. Ionic liquids (ILs)-based adhesives, containing ILs segment, utilizing ILs chemical structure as either the primary adhesive component or key functional group, have materialized as a highly transformative subject matter for cutting-edge and emerging applications. Rational adhesive design strategies, carefully balancing adhesion and cohesion behavior, are also required when constructing ILs-based adhesives.

Immunogenic cell death signature predicts survival and reveals the role of VEGFA + Mast cells in lung adenocarcinoma.

Lung cancer is prevalent worldwide and is a major cause of cancer-related mortality. Despite being the primary model for immunotherapy research, the response rates of lung cancer patients to immunotherapy are unsatisfactory. Furthermore, research on immunogenic cell death (ICD) in lung cancer is limited, which limits the development of strategies that combine ICD-related therapies with immunotherapy.

Real-time warning method for sand plugging in offshore fracturing wells.

Sand plugging during hydraulic fracturing is one of the primary causes of operational failure. Existing methods for identifying sand plugging during fracturing suffer from issues such as time-consuming, low accuracy, and inability to provide real-time warning. Addressing these challenges, this study leverages offshore hydraulic fracturing operational data and reports to propose a novel method for intelligent identification and real-time warning of sand plugging.

In Situ Infared Optical Fiber Sensor Monitoring Reactants and Products Changes during Photocatalytic Reaction.

An in situ monitoring reaction can better obtain the variations during the progression of the photocatalytic reaction. However, the complexity of the apparatus and the limited applicability of substances are the common challenges faced by most in situ monitoring methods. Here, we invented an in situ infrared optical fiber sensor to monitor the reactants and products during photocatalytic reaction.

Size-specific clonidine-loaded liposomes: Advancing melanoma microenvironment suppression with safety and precision.

The immunosuppressive tumor microenvironment (TME) plays a crucial role in the progression and treatment resistance of melanoma. Modulating the TME is thus a key strategy for enhancing therapeutic outcomes. Previousstudies have identified clonidine (CLD), an α2-adrenergic receptor agonist, as a promising agent that enhances T lymphocyte infiltration and reduces myeloid-derived suppressor cells within the TME, thereby promoting antitumor immune responses.

Low-loss nodeless hollow-core anti-resonant soft glass fiber for the 4 µm mid-infrared spectral range.

Infrared soft glass hollow-core anti-resonant fibers (HC-ARF) with low loss, excellent mode purity, and robust high-power transmission capabilities have vast potential in mid-infrared high-power laser transmission and biomedical fields. Despite this, the fabrication of these fibers still faces formidable challenges, coupled with an incomplete understanding of the transmission characteristics, thereby amplifying the value of further exploration. In this paper, we fabricate a six-cell nodeless infrared HC-ARF originating from purified sulfide glass, synthesized using a meticulous "stack-and-draw" method and dual-gas-path pressure control method.

Integrated multiomics revealed adenosine signaling predict immunotherapy response and regulate tumor ecosystem of melanoma.

Extracellular adenosine is extensively involved in regulating the tumor microenvironment. Given the disappointing results of adenosine-targeted therapy trials, personalized treatment might be necessary, tailored to the microenvironment status of individual patients. Here, we introduce the adenosine signaling score (ADO-score) model using non-negative matrix fraction identified patient subtypes using publicly available melanoma dataset, which aimed to profile adenosine signaling-related genes and construct a model to predict prognosis.

Design and fabrication of a tellurite hollow-core anti-resonant fiber for mid-infrared applications.

The hollow core anti-resonant fibers (HC-ARFs) based on soft glass are in high demand for 3-6 µm laser delivery. A HC-ARF based on tellurite glass with 6 touching capillaries as cladding was designed and fabricated for the first time, to the best of our knowledge. A relatively low loss of 3.

Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma.

Purpose: Melanoma is widely utilized as a prominent model for the development of immunotherapy, thought an inadequate immune response can occur. Moreover, the development of apoptosis-related therapies and combinations with other therapeutic strategies is impeded by the limited understanding of apoptosis's role within diverse tumor immune microenvironments (TMEs).

Methods: Here, we constructed an apoptosis-related tumor microenvironment signature (ATM) and employ multi-dimensional analysis to understand the roles of apoptosis in tumor microenvironment.

Low-Frequency Ultrasound Sensitive Piezo1 Channels Regulate Keloid-Related Characteristics of Fibroblasts.

Keloids are benign fibroproliferative tumors that severely diminish the quality of life due to discomfort, dysfunction, and disfigurement. Recently, ultrasound technology as a noninvasive adjuvant therapy is developed to optimize treatment protocols. However, the biophysical mechanisms have not yet been fully elucidated.

Topical antimitotic treatments for plantar warts are more beneficial: A Bayesian network meta-analysis of randomized controlled trials.

Background: Plantar warts are common infectious cutaneous growths causing severe physiological and psychological discomforts in patients and heaving global financial burdens. However, paucity of clear-cut guidelines for plantar warts, selecting appropriate treatments for plantar warts remains challenging. The objective of the study is to evaluate the efficacy and safety of common treatments for plantar warts.

A Simple and Effective Method to Enhance the Mechanical Properties, Dimensional Stability, and Mildew Resistance of Bamboo Scrimber.

Given the increasingly prominent contradiction between the supply of and demand for wood, the abundant resource of bamboo can be a good substitute. Bamboo scrimber can effectively improve the utilization rate of bamboo and has good mechanical properties. However, bamboo scrimber has the problem of poor mildew resistance, and does not meet the requirements for outdoor applications.

Numerical and experimental investigations on the propagation property of a mid-infrared 7 × 1 multimode fiber combiner.

Mid-infrared fiber combiners have great potential in power and spectral combination. However, studies on mid-infrared transmission optical field distributions using these combiners are limited. In this study, we designed and fabricated a 7 × 1 multimode fiber combiner based on sulfur-based glass fibers and observed approximately 80% per-port transmission efficiency at 4.

Design and fabrication of a chalcogenide hollow-core anti-resonant fiber for mid-infrared applications.

Chalcogenide hollow-core anti-resonant fibers (HC-ARFs) are a promising propagation medium for high-power mid-infrared (3-5 µm) laser delivery, while their properties have not been well understood and their fabrications remain challenging. In this paper, we design a seven-hole chalcogenide HC-ARF with touching cladding capillaries, which was then fabricated from purified AsS glass by combining the "stack-and-draw" method with a dual gas path pressure control technique. In particular, we predict theoretically and confirm experimentally that such medium exhibits higher-order mode suppression properties and several low-loss transmission bands in the mid-infrared spectrum, with the measured fiber loss being as low as 1.

Wider indications and more efficient drug delivery: A bibliometric analysis and visualization of photodynamic therapy in skin cancer.

Background: Photodynamic therapy (PDT) has been widely accepted in keratocyte carcinoma and an increasing number of literatures concerning PDT in skin cancer is published. But a detailed examination of publication patterns of PDT in skin cancer has not yet been carried out.

Methods: Bibliographies were retrieved from Web of Science Core Collection restricted the publication date from January 1, 1985 to December 31, 2021.

Research Trends in Immune Checkpoint Blockade for Melanoma: Visualization and Bibliometric Analysis.

Background: Melanoma is one of the most life-threatening skin cancers; immune checkpoint blockade is widely used in the treatment of melanoma because of its remarkable efficacy.

Objective: This study aimed to conduct a comprehensive bibliometric analysis of research conducted in recent decades on immune checkpoint blockade for melanoma, while exploring research trends and public interest in this topic.

Methods: We summarized the articles in the Web of Science Core Collection on immune checkpoint blockade for melanoma in each year from 1999 to 2020.

PDA modified NIR-II NaErYbFnanoparticles with high photothermal effect.

Polydopamine (PDA)-modified NaErYbnanoparticles were synthesized, with strong NIR-II emission, quantum yield of 29.63%, and excellent photothermal performance. Crystal phases and microstructures are characterized.

qPCR-Based Antibiotics Resistance Assay (ACQUIRE) Reveals Widespread Macrolide Resistance in Acne Patients and Can Eliminate Macrolide Misuse in Acne Treatment.

Background: Macrolides have been widely used to treat moderate-to-severe acne for more than 50 years. However, the prevalent antibiotic resistance of Propionibacterium acnes, along with the absence of clinically available resistance tests, has made macrolide misuse a frequent occurrence around the globe, with serious consequences.

Objective: We developed (qPCR)-based antibiotics resistance assay (ACQUIRE) to enable fast and accurate detection of macrolide resistance in clinical settings, representing an opportunity to administer antibiotics more wisely and improve the quality of care.

MITOGENOME ANNOUNCEMENTSCharacterization of the complete chloroplast genome of the Chinese endangered species D. Don.

D. Don 1852 is a Class I endangered species in China having important ornamental and breeding values. This study used Illumina high-throughput sequencing technology to sequence the complete chloroplast genome of The genome features of and its phylogenetic relationships were determined.

Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota Perspective.

Since the 1950s, gradual changes in the gut microbiota of patients with hepatic encephalopathy have been observed. Previous research has indicated potential associations between the gut and brain, and the gut microbiota is becoming a hot topic in research on diseases of the nervous system. However, for the past few decades, studies of hepatic encephalopathy have been restricted to controlling the gut microbiota during macroscopic manipulation, such as probiotic intervention, while its clinical use remains controversial, and the cellular mechanisms underlying this condition are still poorly understood.

Association of previous treatment with anti-tumour necrosis factor inhibitors with the effectiveness of secukinumab in the treatment of psoriatic arthritis: systematic review and meta-analysis.

Objectives: We sought to systematically investigate the effectiveness of secukinumab in psoriatic arthritis (PsA) patients who previously received TNFs inhibitor (TNFi) treatment and those who were TNFi naïve.

Methods: Databases (PubMed, EMBase and Cochrane library) and ClinicalTrials.gov were searched from inception to 22 May 2020 for randomized control trails and observational studies of secukinumab, with or without a history of previous anti-TNFi treatment, in PsA.

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment.

Rare earth-doped nanoparticles have been widely used in disease diagnosis, drug delivery, tumor therapy, and bioimaging. Among various bioimaging methods, the fluorescence imaging technology based on the rare earth-doped nanoparticles can visually display the cell activity and lesion evolution in living animals, which is a powerful tool in biological technology and has being widely applied in medical and biological fields. Especially in the band of near infrared (700-1700 nm), the emissions show the characteristics of deep penetration due to low absorption, low photon scattering, and low autofluorescence interference.

A novel photostable near-infrared-to-near-infrared fluorescent nanoparticle for in vivo imaging.

Water-soluble K HoLi F (KHLF) nanoprobes with the excitation and emission both in the near-infrared (NIR) region were developed and first demonstrated for in vivo imaging of living mice. The PEG coating endows the nanoprobes with good water solubility and biocompatibility. Doping with Ho ions is capable of emitting NIR fluorescence with two peaks centered, respectively, at 887 and 1,180 nm once excited by a 808 nm laser; meanwhile, it also possess good photothermal conversion performance.