A novel clinical data management platform for acute pancreatitis.

This study presents a multi-center clinical data management platform that facilitates unified and structured management of real-world data and serves as an ideal tool to enhance the quality and progress of clinical research related to severe acute pancreatitis (SAP). The use of the platform enables clinical teams to obtain safe, accurate, structurally unified, traceable, scene-clear, and fully functional real-world medical data in the diagnosis, treatment, and research of acute pancreatitis (AP).

Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and Study.

Background: Cadmium (Cd) is a highly toxic and widespread environmental oxidative stressor that causes a myriad of health problems, including osteoporosis and bone damage. Although nuclear factor erythroid 2-related factor 2 (NRF2) and its Cap 'n' Collar and basic region Leucine Zipper (CNC-bZIP) family member nuclear factor erythroid 2-related factor 1 (NRF1) coordinate various stress responses by regulating the transcription of a variety of antioxidant and cytoprotective genes, they play distinct roles in bone metabolism and remodeling. However, the precise roles of both transcription factors in bone loss induced by prolonged Cd exposure remain unclear.

Data fusion of near-infrared and mid-infrared spectroscopy for rapid origin identification and quality evaluation of Lonicerae japonicae flos.

A data fusion strategy based on near-infrared (NIR) and mid-infrared (MIR) spectroscopy techniques were developed for rapid origin identification and quality evaluation of Lonicerae japonicae flos (LJF). A high-level data fusion for origin identification was formed using the soft voting method. This data fusion model achieved accuracy, log-loss value and Kappa value of 95.

The mechanism of fluidity improvement of cement slurry by graphene oxide: a study on nanofriction.

Graphene oxide (GO) as a nano-reinforcing material has received extensive attention in cement composite materials. This paper employed molecular dynamics to simulate the friction process of calcium silicate hydrate (CSH) particles in the presence of double-sided and single-sided GCOOH (graphene oxide with a -COOH functional group, covering 10% of the surface). The investigation uncovered the lubricating effects of bifacial and unifacial GCOOH on the CSH interface.

Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms.

Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet been established. We examined the precise roles of Nrf2 in regulating antioxidants and reactive oxygen species (ROS) levels, especially the cytoplasmic and mitochondrial ROS during osteoclastogenesis in vitro. In the current study, we found that the absence of promotes osteoclast differentiation in bone-marrow-derived macrophages (BMMs) and RAW 264.

Retrorectal mucinous adenocarcinoma arising from a tailgut cyst: A case report and review of literature.

Background: Tailgut cysts are defined as congenital cysts that develop in the rectosacral space from the residue of the primitive tail. As a congenital disease, caudal cysts are very rare, and their canceration is even rarer, which makes the disease prone to misdiagnosis and delayed treatment. We describe a case of caudal cyst with adenocarcinogenesis and summarize in detail the characteristics of cases with analytical value reported since 1990.

Cyanidin-3--glucoside extracted from the Chinese bayberry ( Sieb. et Zucc.) alleviates antibiotic-associated diarrhea by regulating gut microbiota and down-regulating inflammatory factors in NF-κB pathway.

Chinese bayberry has been used to treat diarrhea in China for more than 2,000 years, but the mechanism is not clear. Due to the extensive use of antibiotics, antibiotic-associated diarrhea (AAD) is becoming more and more common in clinic, but there is no effective drug for the treatment. The present study aimed to explore the therapeutic effect of Chinese bayberry on AAD for the first time, and explained the underlying mechanism from different aspects.

Valorization of municipal solid waste incineration bottom ash (MSWIBA) into cold-bonded aggregates (CBAs): Feasibility and influence of curing methods.

The municipal solid waste incineration bottom ash (MSWIBA) contains amounts of hazardous elements or composition, and its disposal to landfills may pose a serious threat to the ground water and soil. To reduce the environmental impact of MSWIBA, a novelty application into the utilization of MSWIBA for the manufacture of cold-bonded aggregates (CBAs) was investigated in this study. This study explored the impacts of curing systems on the comprehensive properties of CBAs.

In situ growth of corrosion resistant Mg-Fe layered double hydroxide film on Q235 steel.

Hypothesis: In situ grown layered double hydroxide (LDH) is commonly used one of the anticorrosion ways for metal materials; Due to the dense growth of LDH on the metal surface, its special layered structure can effectively delay the corrosion rate of metal.

Methods: In this study, we use a hydrothermal method to successfully grow Mg-Fe LDH film on steel substrates based on self-supplied Fe ions. The films were characterized by X-ray diffraction, scanning electron microscopy, and X-ray energy dispersive spectrometry.

Stabilisation/solidification of municipal solid waste incineration fly ash by phosphate-enhanced calcium aluminate cement.

Landfill disposal of municipal solid waste incineration fly ash (MIFA) presents significant environmental and economic burden. This study proposed a novel and high-efficiency approach for stabilisation/solidification (S/S) of MIFA by phosphate-modified calcium aluminate cement (CAC). Experimental results showed that the presence of Pb (the most leachable metal contaminant in the MIFA) retarded the early-stage reaction of CAC, resulting in an extension of setting time and a significant decline of compressive strength of CAC pastes.

Influence of lead on stabilization/solidification by ordinary Portland cement and magnesium phosphate cement.

Inorganic binder-based stabilization/solidification (S/S) of Pb-contaminated soil is a commonly used remediation approach. This paper investigates the influences of soluble Pb species on the hydration process of two types of inorganic binders: ordinary Portland cement (OPC) and magnesium potassium phosphate cement (MKPC). The environmental leachability, compressive strength, and setting time of the cement products are assessed as the primary performance indicators.

Self-immunity microcapsules for corrosion protection of steel bar in reinforced concrete.

A novel microcapsule-based self-immunity system for reinforced concrete is proposed. Its feasibility for hindering the corrosion of steel rebar by means of lifting the threshold value of [Cl(-)]/[OH(-)] is discussed. Precisely controlled release behavior enables corrosion protection in the case of depassivation.