Publications by authors named "Yanran Zhu"

Article Synopsis
  • The study addresses the urgent need for new antimicrobial agents to combat antibiotic resistance from Gram-negative pathogens.
  • Researchers utilized deep learning techniques to modify antimicrobial peptides (AMPs) from a prawn species, enhancing their effectiveness against various bacteria.
  • The findings demonstrate the successful application of small dataset learning and evolutionary principles in designing AMPs, showcasing their potential as alternatives to traditional antibiotics.
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This paper introduces multiple state or spatial-diffusion coupled fractional-order reaction-diffusion neural networks, and discusses the outer synchronization and outer H synchronization problems for these coupled fractional-order reaction-diffusion neural networks (CFRNNs). The Lyapunov functional method, Laplace transform and inequality techniques are utilized to obtain some outer synchronization conditions for CFRNNs. Moreover, some criteria are also provided to make sure the outer H synchronization of CFRNNs.

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Fast transport of monovalent ions is imperative in selective monovalent ion separation based on membranes. Here, we report the in situ growth of crown ether@UiO-66 membranes at a mild condition, where dibenzo-18-crown-6 (DB18C6) or dibenzo-15-crown-5 is perfectly confined in the UiO-66 cavity. Crown ether@UiO-66 membranes exhibit enhanced monovalent ion transport rates and mono-/divalent ion selectivity, due to the combination of size sieving and interaction screening effects toward the complete monovalent ion dehydration.

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In the intricate realm of animal biology, a multitude of vital processes heavily rely on precisely orchestrated proteinase cascades, but the potential for havoc makes proteinase inhibitors indispensable, with serine proteinase inhibitors (serpins) at the forefront, serving as custodians of homeostasis and participating in various critical biological processes. Importantly, there are still many unexplored facets of serpin functionality. In this study, we focused on the serpin family proteins from Marsupenaeus japonicus, utilizing a fine-tuned pretrained protein language model.

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Introduction: Antimicrobial peptides (AMPs) are valuable alternatives to traditional antibiotics, possess a variety of potent biological activities and exhibit immunomodulatory effects that alleviate difficult-to-treat infections. Clarifying the structure-activity relationships of AMPs can direct the synthesis of desirable peptide therapeutics.

Objectives: In this study, the lipopolysaccharide-binding domain (LBD) was identified through machine learning-guided directed evolution, which acts as a functional domain of the anti-lipopolysaccharide factor family of AMPs identified from Marsupenaeus japonicus.

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The Chinese sea bass () is an important aquaculture fish, but diseases caused by have led to severe economic losses to the aquaculture industry in recent years. To date, only a few studies have focused on the relationship between the intestinal immune response and changes in intestinal microbes by infection. Here, we report the transcriptome and intestinal changes in infected sea bass.

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Membranes of high ion permselectivity are significant for the separation of ion species at the subnanometer scale. Here, we report porous organic cage (i.e.

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The traditional ion-exchange membranes face the trade-off effect between the ion flux and perm-selectivity, which limits their application for selective ion separation. Herein, we amalgamated various amounts of the ZSM-5 with the polyvinyl alcohol as ions transport pathways to improve the permeability of monovalent cations and exclusively reject the divalent cations. The highest contents of ZSM-5 in the mixed matrix membranes (MMMs) can be extended up to 60 wt% while the MMMs with optimized content (50 wt%) achieved high perm-selectivity of 34.

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