Exploring plant growth promoting traits and biocontrol potential of new isolated BS-2301 strain in suppressing through various mechanisms.

(Lib.) de Bary is the causative agent of stem white mold disease which severely reduces major crop productivity including soybean and rapeseed worldwide. The current study aimed to explore plant growth-promoting traits and biocontrol of new isolated BS-2301 to suppress through various mechanisms.

A ribonuclease T2 protein FocRnt2 contributes to the virulence of Fusarium oxysporum f. sp. cubense tropical race 4.

Banana Fusarium wilt, caused by Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4), is a major disease of banana plants worldwide.

Sodium Crotonate Alleviates Diabetic Kidney Disease Partially Via the Histone Crotonylation Pathway.

Diabetic kidney disease (DKD) is a common microvascular complication of diabetes, inflammation and fibrosis play an important role in its progression. Histone lysine crotonylation (Kcr) was first identified as a new type of post-translational modification in 2011. In recent years, prominent progress has been made in the study of sodium crotonate (NaCr) and histone Kcr in kidney diseases.

NGEF is a potential prognostic biomarker and could serve as an indicator for immunotherapy and chemotherapy in lung adenocarcinoma.

Background: Neuronal guanine nucleotide exchange factor (NGEF) plays a key role in several cancers; however, its role in lung adenocarcinoma (LUAD) remains unclear. The aim of this study was to evaluate the efficacy of NGEF as a prognostic biomarker and potential therapeutic target for LUAD.

Methods: NGEF expression data for multiple cancers and LUAD were downloaded from multiple databases.

Sodium benzoate induces pancreatic inflammation and β cell apoptosis partially via benzoylation.

Epigenetics, specifically histone post-translational modification (HPTM) induced by environmental factors, plays a crucial role in the development of diabetes. Sodium benzoate (NAB) is a widely used additive, however, its potential contribution to diabetes has been largely overlooked. In 2018, a novel HPTM called benzoylation (Kbz) induced by NAB was discovered.

is a Prognostic Biomarker in Pan-Cancer Analysis and Correlates with Immune Infiltration and Immune Molecules in Non-Small Cell Lung Cancer.

Purpose: Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. Immediate early response 5 like () plays crucial roles in progression and prognosis for several tumors, but its role in NSCLC remains unclear.

Patients And Methods: Gene expression and mutation profiles, DNA methylation data, and clinical information for cancers were downloaded from multiple databases.

Diversity and composition of microbial communities in Jinsha earthen site under different degree of deterioration.

Earthen sites are the important cultural heritage that carriers of human civilization and contains abundant history information. Microorganisms are one of important factors causing the deterioration of cultural heritage. However, little attention has been paid to the role of biological factors on the deterioration of earthen sites at present.

β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications.

Previous studies have found that β-Hydroxybutyrate (BHB), the main component of ketone bodies, is of physiological importance as a backup energy source during starvation or induces diabetic ketoacidosis when insulin deficiency occurs. Ketogenic diets (KD) have been used as metabolic therapy for over a hundred years, it is well known that ketone bodies and BHB not only serve as ancillary fuel substituting for glucose but also induce anti-oxidative, anti-inflammatory, and cardioprotective features via binding to several target proteins, including histone deacetylase (HDAC), or G protein-coupled receptors (GPCRs). Recent advances in epigenetics, especially novel histone post-translational modifications (HPTMs), have continuously updated our understanding of BHB, which also acts as a signal transduction molecule and modification substrate to regulate a series of epigenetic phenomena, such as histone acetylation, histone β-hydroxybutyrylation, histone methylation, DNA methylation, and microRNAs.

Crotonylation and disease: Current progress and future perspectives.

Histone lysine crotonylation was first identified as a new type of post-translational modification in 2011. In recent years, prominent progress has been made in the study of histone and nonhistone crotonylation in reproduction, development, and disease. Although the regulatory enzyme systems and targets of crotonylation partially overlap with those of acetylation, the peculiar CC bond structure of crotonylation suggests that crotonylation may have specific biological functions.

Screening of Candidate Effectors from by In Vitro Secretomic Analysis.

is the causal agent of rice blast, one of the most serious diseases of rice worldwide. Secreted proteins play essential roles during a -rice interaction. Although much progress has been made in recent decades, it is still necessary to systematically explore -secreted proteins and to analyze their functions.

Novel histone post-translational modifications in diabetes and complications of diabetes: The underlying mechanisms and implications.

Diabetes is a group of global epidemic diseases with high prevalence and morbidity. The pathophysiological changes of diabetes can be affected by genes, environmental factors, and several socioeconomic factors. Histone post-translational modification is the central epigenetic mechanism regulated by genetic and environmental factors.

AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial.

Background: Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current study tests whether the early administration of CQCQD will result in improved clinical outcomes in predicted MSAP/SAP patients.

Function and mechanism of histone β-hydroxybutyrylation in health and disease.

Histone post-translational modifications (HPTMs) are essential epigenetic mechanisms that affect chromatin-associated nuclear processes without altering the DNA sequence. With the application of mass spectrometry-based proteomics, novel histone lysine acylation, such as propionylation, butyrylation, crotonylation, malonylation, succinylation, glutarylation, and lactoylation have been successively discovered. The emerging diversity of the lysine acylation landscape prompted us to investigate the function and mechanism of these novel HPTMs in health and disease.

The Forms, Channels and Conditions of Regional Agricultural Carbon Emission Reduction Interaction: A Provincial Perspective in China.

Agricultural emission reduction is a key objective associated with sustainable agricultural development and a meaningful way to slow down global warming. Based on the comprehensive estimation of agricultural carbon emissions, this study applied the traditional spatial Durbin model (SDM) to analyze the type of regional emission reduction interaction and explore whether it is a direct or an indirect interaction caused by technology spillovers. Moreover, geographic, economic, and technical weights were used to discuss the channels of emission reduction interactions.

Construction of a redox-related gene signature for overall survival prediction and immune infiltration in non-small-cell lung cancer.

An imbalance in the redox homeostasis has been reported in multiple cancers and is associated with a poor prognosis of disease. However, the prognostic value of redox-related genes in non-small-cell lung cancer (NSCLC) remains unclear. RNA sequencing data, DNA methylation data, mutation, and clinical data of NSCLC patients were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases.

The role and mechanism of butyrate in the prevention and treatment of diabetic kidney disease.

Diabetic kidney disease (DKD) remains the leading cause of the end-stage renal disease and is a major burden on the healthcare system. The current understanding of the mechanisms responsible for the progression of DKD recognizes the involvement of oxidative stress, low-grade inflammation, and fibrosis. Several circulating metabolites that are the end products of the fermentation process, released by the gut microbiota, are known to be associated with systemic immune-inflammatory responses and kidney injury.

Safety and efficacy of intravenous hydromorphone patient-controlled analgesia versus intramuscular pethidine in acute pancreatitis: An open-label, randomized controlled trial.

Hydromorphone patient-controlled analgesia (PCA) provides satisfactory postoperative pain therapy, but its effect has not been assessed in acute pancreatitis (AP). To assess the safety and efficacy of intravenous hydromorphone PCA for pain relief in AP. This open-label trial included AP patients admitted within 72 h of symptom onset, aged 18-70 years old, and with Visual Analog Scale (VAS) for pain intensity ≥5.

Anti-Inflammatory Effects and Molecular Mechanisms of Shenmai Injection in Treating Acute Pancreatitis: Network Pharmacology Analysis and Experimental Verification.

Background: Acute pancreatitis (AP) is an inflammatory disorder of the exocrine pancreas without specific treatment. Shenmai injection (SMI) was reported to eliminate the severity of experimental AP. This study aimed to explore the mechanisms underlying the synergistic protective effects of SMI on AP based on network pharmacology and experimental validation.

Sodium Butyrate Attenuates Diabetic Kidney Disease Partially via Histone Butyrylation Modification.

Inflammation and fibrosis are the important pathophysiologic processes in diabetic kidney disease (DKD), which is induced by epigenetics, especially histone posttranslational modification (HPTMs). Recent reports highlighted that butyrate, one of the short-chain fatty acids (SCFAs) primarily originated from the fermentation of dietary fiber in the gut, attenuates inflammation and fibrosis in the prevention and treatment of DKD; however, the molecular mechanisms are still unclear. Histone lysine butyrylation (Kbu), a novel histone modification marker induced by butyrate, has been found to be involved in the regulation of pathophysiological processes.

In Vitro Secretome Analysis Suggests Differential Pathogenic Mechanisms between f. sp. Race 1 and Race 4.

Banana Fusarium wilt, caused by the fungus pathogen f. sp. (Foc), is a devastating disease that causes tremendous reductions in banana yield worldwide.

Assessment on effects of transplastomic potato plants expressing Colorado potato beetle β-Actin double-stranded RNAs for three non-target pests.

RNA interference has been proved as an efficient technology for pest control through the silencing of essential genes of targeted insects. We had previously shown that the expression of double-stranded RNAs (dsRNAs) in plastids of plants offers a great potential for efficiently controlling Colorado potato beetle (CPB, Leptinotarsa decemlineata) (Coleoptera, Chrysomelidae). However, whether these transplastomic plants have an impact on other non-target pests was not investigated.

Calculation, elasticity and regional differences of agricultural greenhouse gas shadow prices.

Global warming is one of the major threats to human survival and social development. Agriculture, as an important source of greenhouse gas (GHG) emissions, cannot be ignored. China is the world's largest carbon emitter, and if it does not actively participate, other countries in the world will not be able to achieve the 1.

The N-glycan processing enzymes β-D-N-acetylhexosaminidase are involved in ripening-associated softening in strawberry fruit.

Excessive softening of fruits during the ripening process leads to rapid deterioration. N-glycan processing enzymes are reported to play important roles during fruit ripening associated softening. Efforts have been made to identify and purify β-D-N-acetyl hexosaminidase (β-Hex) from strawberry fruit and also to investigate its function during ripening.