Aerobic thiyl radical addition/cyclization of N-methacryloyl benzamides for the synthesis of isoquinoline-1,3(2H,4H)-dione derivatives.

A highly effective oxidative thiyl radical addition/cyclization of N-methacryloylbenzamides was explored using dioxygen as the sole terminal oxidant without the use of precious and/or toxic transition-metal catalysts. This method provides convenient access to a variety of useful sulfide-containing 4,4-disubstituted isoquinoline-1,3-diones by constructing C-S and C-C bonds in one step.

Palladium-catalyzed thiolation of alkanes and ethers with arylsulfonyl hydrazides.

A new method for the preparation of alkyl aryl sulfides through direct oxidative thiolation of alkanes or ethers with arylsulfonyl hydrazides using di-tert-butyl peroxide (DTBP) as an oxidant catalyzed by Pd(OAc)2 has been reported. The C-H bonds in various alkanes or ethers were successfully converted into C-S bonds to yield the corresponding sulfides in moderate to good yields.

Metal-free oxidative C(sp3)-H bond thiolation of ethers with disulfides.

A novel method for the preparation of alkyl aryl sulfides through direct oxidation thiolation of commercial ethers with diaryl disulfides using di-tert-butyl peroxide (DTBP) as the oxidant without a metal catalyst was established. The C(sp(3))-H bond in various ethers was successfully converted into a C-S bond, and the corresponding sulfides were achieved with moderate to high yields.

Treatment of infected soft tissue blast injury in swine by regulated negative pressure wound therapy.

Objective: This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected blast injuries in swine.

Background: Approximately 30% to 80% of blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries.

New swine model of infected soft tissue blast injury.

Background: War injuries, especially blast injuries, have a high risk of infection. However, no animal models of infected war injuries have been built in large animals, which retards both the understanding and the treatment optimization of infected war injuries.

Methods: Soft tissue blast injuries were created by explosion of electric detonators in white domestic pigs.

[Effectiveness evaluation of composite skin grafts in repairing deep burn wounds in functional regions].

Objective: To evaluate the long-term effectiveness of composite grafts of acellular dermal matrix (ADM) and autologous split-thickness skin in repairing deep burn wounds.

Methods: Between June 2002 and December 2008, 30 patients (42 wound) were treated. There were 25 males and 5 females, aged 3-52 years with a median age of 31 years.

Silica sulfuric acid promotes aza-Michael addition reactions under solvent-free condition as a heterogeneous and reusable catalyst.

A highly efficient, inexpensive, recyclable, convenient, and green protocol for chemoselective aza-Michael addition reactions of amines/thiols to alpha,beta-unsaturated compounds using silica sulfuric acid (SSA or SiO(2)-SO(3)H) was developed. This method is simple, convenient and the title compounds are produced in good to excellent yields.

[4-(Methyl-sulfon-yl)phen-yl]acetic acid.

In the crystal structure of the title compound, C(9)H(10)O(4)S, centrosymmetrically related mol-ecules are linked into dimers by inter-molecular O-H⋯O hydrogen bonds. Unconventional C-H⋯O hydrogen-bond inter-actions are also present, connecting dimers into a three-dimensional network.