Publications by authors named "Yanpo Si"

Article Synopsis
  • Lung cancer is a major health crisis in China with the highest rates of occurrence and death among cancers, prompting research into treatments like rabdoternin E.
  • The study found that rabdoternin E inhibits lung cancer cell growth by increasing reactive oxygen species (ROS), causing cell cycle arrest, triggering cell death (apoptosis), and activating certain signaling pathways related to cell stress.
  • Animal experiments showed that rabdoternin E significantly reduced tumor size and weight without harming normal cells, indicating its potential as a new therapy for lung cancer.
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Insomnia is the second most prevalent mental illness worldwide. Periostracum cicadae (PC), as an animal traditional Chinese medicine with rich pharmacological effects, has been documented as a treatment for children's night cries, and later extended to treat insomnia. This study aimed to investigate the effects of PC extract and N-acetyldopamine compounds in ameliorating insomnia.

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Lilium brownii (L. brownii) is a plant that can be used for both medicine and food. Its bulbs are commonly used to treat neurological disorders like depression, insomnia, and Parkinson's disease (PD).

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Bulbs of Lilium brownii, commonly known as "Bai-he" in China, serve both edible and medicinal purposes in clinical practice. In this study, two new isospirostanol-type saponins were isolated from L. brownii, and their structures were identified by spectroscopic method, and absolute configurations were elucidated by comprehensive analysis of spectral data obtained from combined acid hydrolysis.

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Purpose: To reveal the potential mechanism of PDA on hepatocellular carcinoma SMMC-7721 cells in vitro.

Methods: The cytotoxic activity, colony formation, cell cycle distribution, apoptosis and their associated protein analysis, intracellular reactive oxygen species (ROS) and Ca levels, proteins in Nrf2 and Ntoch pathways and metabolite profiles of PDA against hepatocellular carcinoma were investigated.

Results: PDA with cytotoxic activity inhibited cell proliferation and migration, increased intracellular ROS, Ca levels and MCUR1 protein expression in a dose-dependent manner, caused cell cycle arrest in the S phase and induced apoptosis via adjusting the levels of Bcl-2, Bax, and Caspase 3 proteins, and inhibited the activation of Notch1, Jagged, Hes1, Nrf2 and HO-1 proteins.

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One new (1) and 11 reported ent-kaurane diterpenoids (2-12) were received from the ethanol extract of the air-dried aerial parts of Rabdosia rubescens collected in Jiyuan. Their structures were determined in accordance with high resolution electrospray ionization mass spectroscopy, one dimensional (1D) and two-dimensional (2D) NMR spectroscopy and the data published in the literature. The cytotoxic activity of these isolated compounds was assessed against SMMC-7721, A-549, H-1299 and SW-480 cancer cell lines.

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One new () and six known cycloartane triterpenoids (), along with seven reported abietane diterpenoids (), were isolated from the bark of the branches of , of which compounds were also received for the first time from the genus of . Structural elucidation of all the compounds was carried out by extensive spectroscopic analyses. Additionally, the antifungal activity of isolated compounds - was evaluated by inhibiting the growth of fungal mycelium.

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Background: Fibrosis is one of the most common pathological features of the aging process of the kidney, and fibrosis in aging kidneys also aggravates the process of chronic kidney disease (CKD). Corallodiscus flabellata B. L.

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Gut microbiota homeostasis in the organism and insomnia have been reported to influence each other. In the study, a method of 16S rRNA gene sequencing combined with ultra-high performance liquid chromatography-mass/mass spectrometry was adopted to evaluate the effects of Lilium brownie (LB) on intestinal flora and metabolic profiles of serum, hypothalamus and hippocampus in insomnia rat induced by p‑chlorophenylalanine (PCPA). It was observed that the imbalance in the diversity and abundance of gut microbiota induced by PCPA was restored after LB intervention.

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Bark of Phellodendron chinense Schneid. (Rutaceae), called "Huang Bai" in China, is one of the 50 most used Chinese medicines in clinical practice. In this paper, a new isoquinoline alkaloid glycoside was isolated from P.

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A UPLC-Q-TOF/MS-based metabolomics study was carried out to explore the intervening mechanism of (Craib) B. L. Burtt (CF) extract on Alzheimer's disease (AD).

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Context: var. Cotton ( genus, Liliaceae) is an edible plant and a herb used in China to alleviate insomnia.

Objective: To investigate the alleviating insomnia mechanism of (LD).

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Many plants in the genus Zanthoxylum, belonging to the Rutaceae family, are used as folk medicines for the treatment of various diseases, which have gained much attention for their phytochemical and pharmacological activity investigations. Alkaloids are the largest secondary metabolites with structurally diverse types found in this genus and they demonstrate a wide range of biological activities. The aim of this review is to provide a summary on the isolation, classification, and biological properties of alkaloids from Zanthoxylum species, which also will bring more attention to other researchers for further biological study on alkaloids for the new drug development.

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Antibiotics have saved hundreds of millions of patient's lives, but there are also many side effects. This paper mainly studies the regulation of Chinese yam on antibiotic-induced gut dysbiosis in rats. Male Wistar rats were divided into three groups, normal control group, antibiotic group, and Chinese yam group.

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