The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation.

Background And Purpose: Psoriasis is a chronic inflammatory skin disease associated with both innate and adaptive immune responses. The stimulator of interferon genes (STING) protein engages in sensing of cytosolic DNA to initiate dsDNA-driven immune responses. In vitro and in vivo anti-psoriasis effects of STING antagonist H-151 were explored.

STING inhibitors target the cyclic dinucleotide binding pocket.

Cytosolic DNA activates cGAS (cytosolic DNA sensor cyclic AMP-GMP synthase)-STING (stimulator of interferon genes) signaling, which triggers interferon and inflammatory responses that help defend against microbial infection and cancer. However, aberrant cytosolic self-DNA in Aicardi-Goutière's syndrome and constituently active gain-of-function mutations in STING in STING-associated vasculopathy with onset in infancy (SAVI) patients lead to excessive type I interferons and proinflammatory cytokines, which cause difficult-to-treat and sometimes fatal autoimmune disease. Here, in silico docking identified a potent STING antagonist SN-011 that binds with higher affinity to the cyclic dinucleotide (CDN)-binding pocket of STING than endogenous 2'3'-cGAMP.

Fabrication, characterization, and application of ternary magnetic recyclable BiWO/BiOI@FeO composite for photodegradation of tetracycline in aqueous solutions.

We aim at fabricating a ternary magnetic recyclable BiWO/BiOI@FeO composite that could be applied for photodegradation of tetracycline (TC) from synthetic wastewater. To identify any changes with respect to the composite's morphology and crystal structure properties, ΧRD, FTIR, FESEM-EDS, PL and VSM analyses are carried out. The effects of FeO loading ratio on the BiWO/BiOI for TC photodegradation are evaluated, while operational parameters such as pH, reaction time, TC concentration, and photocatalyst's dose are optimized.

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I.

Activation of AMPK emerges as a potential therapeutic approach to metabolic diseases. AdipoRon is claimed to be an adiponectin receptor agonist that activates AMPK through adiponectin receptor 1 (AdipoR1). However, AdipoRon also exhibits moderate inhibition of mitochondrial complex I, leading to increased risk of lactic acidosis.

2D Graphene oxide (GO) doped p-n type BiOI/BiWO as a novel composite for photodegradation of bisphenol A (BPA) in aqueous solutions under UV-vis irradiation.

Bisphenol A (BPA) is a refractory pollutant presents in water body that possesses serious threats to living organisms. To deal with it, we investigate and evaluate the effectiveness of GO@BiOI/BiWO composite as a novel photocatalyst for BPA removal from aqueous solutions under UV-vis irradiation. To enhance its removal for BPA, the surface of BiOI/BiWO is modified with graphene oxide (GO).

Co-crystallization of hemimellitic acid with 4,4'-bipyridine forming a pillar-layered hydrogen-bonded network.

Co-crystallization of hemimellitic acid (benzene-1,2,3-tricarboxylic acid) dihydrate (H3HMA.2H2O) with 4,4'-bipyridine (4,4'-bpy) affords the 1:1 co-crystal benzene-1,2,3-tricarboxylic acid-4,4'-bipyridine (1/1), H3HMA.4,4'-bpy or C9H6O6.