RUNX1 promotes proliferation and migration in non-small cell lung cancer cell lines via the mTOR pathway.

RUNX1, a member of the RUNX family of metazoan transcription factors, participates in the regulation of differentiation, proliferation, and other processes involved in growth and development. It also functions in the occurrence and development of tumors. However, the role and mechanism of action of RUNX1 in non-small cell lung cancer (NSCLC) are not yet clear.

Phillyrin restores metabolic disorders in mice fed with high-fat diet through inhibition of interleukin-6-mediated basal lipolysis.

The function of white adipose tissue as an energy reservoir is impaired in obesity, leading to lipid spillover and ectopic lipid deposition. Adipose tissue inflammation can reduce the efficacy of lipid storage in adipocytes by augmenting basal lipolysis through producing interleukin-6 (IL-6). Therefore, pharmacological compounds targeting adipose tissue inflammation or IL-6 signaling might have the potential to combat obesity.

Gene-environment interaction between circadian clock gene polymorphisms and job stress on the risk of sleep disturbances.

Rationale: Sleep disturbances was associated with numerous adverse health outcomes. Many studies have reported that long-term exposure to job stress can lead to sleep disturbances, which may be influenced by genetic and environmental factors.

Objectives: This cross-sectional study investigated whether circadian clock gene polymorphisms modulated the influence of job stress on sleep disturbances in a Chinese Han population, which to our best knowledge has not been explored.

Comparative Transcriptomic Analysis on White and Blue Flowers of Platycodon grandiflorus to Elucidate Genes Involved in the Biosynthesis of Anthocyanins.

Background: has long been used in Northeast Asia as a food and folk medicine to treat various diseases. The intense blue color of corolla is its characteristic feature.

Objectives: By comparing deep transcriptomic data of and its white cultivar, we intended to elucidate the molecular mechanisms concerning the biosynthesis of anthocyanins in this plant.

The complete chloroplast genome of medic (Malvaceae).

Medic is a traditional Chinese medicine, which can be seen nearly everywhere in China. In order to study its complete chloroplast genome, we collected leaves and obtained chloroplast genome information through next-generation sequencing. It showed that the genome whole length is 160,331 bp, resulted from 24,578,194 raw reads with 3,669,530,829 bases in total, and the GC contents ratio is 36.

Clinical features and prognostic factors of patients with COVID-19 in Henan Province, China.

Since December 2019, the novel coronavirus SARS-CoV-2 pandemic (COVID-19) outbroke in Wuhan and spread in China. Here we aimed to investigate the clinical and radiological characteristics of COVID-19 cases. We collected and analyzed the clinical data of 172 hospitalized cases of COVID-19 who were diagnosed via qRT-PCR of nasopharyngeal swabs during January 2020 and February 2020.

Pickled Vegetables Intake Impacts the Metabolites for Gastric Cancer.

Purpose: An increased risk of gastric cancer (GC) for pickled vegetables intake has been suggested, but a complete understanding of its pathogenic origin is still lacking, especially from a metabolic viewpoint. We investigated the plasma metabolites and metabolic pathway alteration of GC related to pickled vegetables intake.

Methods: We analyzed plasma samples collected from 365 gastric cancer patients and 347 healthy individuals, and divided them into three subgroups according to the intake of pickled vegetables.

Enhancing the Interface Contact of Stacking Perovskite Solar Cells with Hexamethylenediammonium Diiodide-Modified PEDOT:PSS as an Electrode.

As an indispensable component of perovskite solar cells (PSCs), the commonly used Au and Ag electrodes still have some problems such as high cost and instability issues with regard to being corroded by iodide ions. In this paper, we report stacking perovskite solar cells (S-PSCs), which can avoid the use of precious metal electrodes and reduce the cost of devices and the requirements of equipment compared to conventional PSCs. The S-PSCs are composed of two semicells: a photoanode and a counter electrode (CE).

Hexylammonium Iodide Derived Two-Dimensional Perovskite as Interfacial Passivation Layer in Efficient Two-Dimensional/Three-Dimensional Perovskite Solar Cells.

Defects locating within grain boundaries or on the film surface, especially organic cation vacancies and iodine vacancies, make the fabrication of perovskite solar cells (PSCs) with superior performance a challenge. Organic ammonium iodide is a promising candidate and has been frequently used to passivate these defects by forming two-dimensional (2D) perovskite. In this work, it is found that the chain length of organic ammonium iodide is a crucial factor on the defect passivation effect.

LATS2 promotes apoptosis in non-small cell lung cancer A549 cells via triggering Mff-dependent mitochondrial fission and activating the JNK signaling pathway.

LATS2 is a classical tumor suppressor that affects non-small cell lung cancer proliferation and mobilization. However, its role in lung cancer cell apoptosis is unknown. The aim of our study is to explore whether LATS2 activates mitochondria-related apoptosis in lung cancer cells.

Inhibition of Ep3 attenuates migration and promotes apoptosis of non-small cell lung cancer cells via suppression of TGF-β/Smad signaling.

Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Prostaglandin E2 (PGE2) regulates various biological processes, including invasion, proliferation and apoptosis. E-prostanoid 3 (Ep3) is a PGE2 receptor, and the functional role of Ep3 in the progression of NSCLC remains unresolved.

Bromine Doping as an Efficient Strategy to Reduce the Interfacial Defects in Hybrid Two-Dimensional/Three-Dimensional Stacking Perovskite Solar Cells.

Solar-to-electricity conversion efficiency, power conversion efficiency (PCE), and stability are two important aspects of perovskite solar cells (PSCs). However, both aspects are difficult to simultaneously enhance. In the recent two years, two-dimensional (2D)/three-dimensional (3D) stacking structure, designed by covering the 3D perovskite with a thin 2D perovskite capping layer, was reported to be a promising method to achieve both a higher PCE and improved stability simultaneously.

Silver-Catalyzed Radical Arylphosphorylation of Unactivated Alkenes: Synthesis of 3-Phosphonoalkyl Indolines.

A silver-catalyzed phosphorylation/cyclization cascade of N-allyl anilines was developed, allowing direct access to 3-phosphonoalkyl indolines, which were previously obtainable only via tedious procedures under harsh/toxic conditions. The unactivated double bond serves as the radical acceptor, whereas H-phosphonates or -phosphine oxides act as the radical precursor. This protocol features simple operation, broad substrate scope, and great exo selectivity, and a gram-scale synthesis could be readily carried out.

Pseudohalogen-Based 2D Perovskite: A More Complex Thermal Degradation Mechanism Than 3D Perovskite.

(MA)Pb(SCN)I, a new pseudohalogen-based 2D perovskite material, was reported as a very stable and promising photo-absorber in PSCs previously. However, the later researchers found that MAPb(SCN)I was not as stable as claimed. Thus, it is very critical to clarify the controversy and reveal the degradation mechanism of MAPb(SCN)I.

Interplay between Exciton and Free Carriers in Organolead Perovskite Films.

For highly interested organolead perovskite based solar cells, the exciton and free carriers are the photoproducts in the working layers. In this study, we revealed their two forms of relations depending on heat-annealing condition. In non-annealed films and single crystal, they are in density-dependent dynamical balance (co-existing).

SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.

The phosphoinositide 3-kinase pathway is one of the most commonly altered pathways in human cancers. The serum/glucocorticoid-regulated kinase (SGK) family of serine/threonine kinases consists of three isoforms, SGK1, SGK2, and SGK3. This family of kinases is highly homologous to the AKT kinase family, sharing similar upstream activators and downstream targets.

Knockdown of MDR1 increases the sensitivity to adriamycin in drug resistant gastric cancer cells.

Gastric cancer is one of the most frequently occurring malignancies in the world. Development of multiple drug resistance (MDR) to chemotherapy is known as the major cause of treatment failure for gastric cancer. Multiple drug resistance 1/P-glycoprotein (MDR1/p-gp) contributes to drug resistance via ATP-dependent drug efflux pumps and is overexpressed in many solid tumors including gastric cancer.

Genome-wide analysis of primary auxin-responsive Aux/IAA gene family in maize (Zea mays. L.).

The phytohormone auxin is important in various aspects of organism growth and development. Aux/IAA genes encoding short-lived nuclear proteins are responsive primarily to auxin induction. Despite their physiological importance, systematic analysis of Aux/IAA genes in maize have not yet been reported.