Publications by authors named "Yannicke Sloots"
Article Synopsis
- Epigenetic age acceleration (EAA) in atherosclerotic plaques is linked to future cardiovascular events, showing that older plaque age can predict mortality risk similar to overall epigenetic age estimators.
- In a study involving 485 human carotid plaques, EAA was correlated with clinical indicators, with patients showing higher EAA having conditions like diabetes and obesity.
- Single-cell RNA sequencing identified smooth muscle and endothelial cells as key contributors to plaque EAA, with the endothelial-to-mesenchymal transition process being linked to accelerated aging in those cells.