Publications by authors named "Yannick Hoogvliets"
Article Synopsis
- MeCP2 is a protein that regulates gene expression and chromatin structure, with two main forms, E1 and E2, and its mutations are linked to Rett syndrome.
- The study investigates how MeCP2 interacts with LEDGF, a transcription regulator, highlighting that the interaction requires a specific domain in MeCP2.
- Results show that a mutation in MeCP2 (R306C), associated with Rett syndrome, weakens its binding to LEDGF, indicating a complex role in maintaining chromatin organization.
