Publications by authors named "Yannick Engole"
Article Synopsis
- Acute kidney injury (AKI) is a serious complication in COVID-19 patients, particularly in a Sub-Saharan African ICU, with an incidence rate of 28.4% among 215 patients studied.
- Key factors linked to AKI include the presence of dyspnea, high SOFA scores, specific blood ratio levels, mechanical ventilation, and the use of Amikacin.
- The mortality rate for patients with AKI in this study was notably high, at 52.5%, indicating a significant impact of kidney damage on overall patient outcomes.
Heparin is widely used in the intensive care unit despite the risk of bleeding it can cause. Although it is rarely reported, hyperkalemia is one of the side effects associated with heparin therapy (unfractionated or fractionated heparin). It would be secondary to hypoaldosteronism by blocking the biosynthesis of aldosterone in the adrenal gland and often appears in context of prolonged heparin therapy or inappropriate renin production in elderly, diabetic, and kidney insufficiency patients.
View Article and Find Full Text PDFBackground: Despite it being a global pandemic, there is little research examining the clinical features of severe COVID-19 in sub-Saharan Africa. This study aims to identify predictors of mortality in COVID-19 patients at Kinshasa Medical Center (KMC).
Methods: In this retrospective, observational, cohort study carried out at the Kinshasa Medical Center (KMC) between March 10, 2020 and July 10, 2020, we included all adult inpatients (≥ 18 years old) with a positive COVID-19 PCR result.
Proteinuria is a marker of severity and poor outcome of patients in intensive care unit (ICU). The objective of this study was to determine the frequency of proteinuria and the risk factors associated with proteinuria in Congolese COVID-19 patients. The present cross sectional study of proteinuria status is a post hoc analysis of data from 80 COVID-19 patients admitted at Kinshasa Medical Center (KMC) from March 10 to July 10, 2020.
View Article and Find Full Text PDFObjective: Early identification of atherosclerosis using a non-invasive tool like ankle-brachial index (ABI) could help reduce the risk for cardiovascular disease among long-term hemodialysis patients. The study objective was to assess the frequency and impact of abnormal ABI as a marker of subclinical peripheral artery disease (PAD) in chronic hemodialysis patients.
Methods: This was a historic cohort study of kidney failure patients on long-term hemodialysis for at least 6 months.
Article Synopsis
- - Valvular calcifications (VCs) are a serious health concern for patients undergoing chronic hemodialysis (HD), leading to higher morbidity and mortality rates.
- - A study involving 60 HD patients in Kinshasa found that VCs were present in 38% of participants, primarily affecting the aortic valve (64%) and to a lesser extent the mitral valve (23%).
- - Key risk factors linked to VCs included hypertension, age over 60, tobacco use, and high phosphorus levels, suggesting that both common and kidney disease-specific factors contribute to this condition.
Prevalence and factors associated with pulmonary arterial hypertension on maintenance hemodialysis patients in Kinshasa, Democratic Republic of Congo: a cross-sectional study.
BMC Nephrol
November 2020
Article Synopsis
- A study was conducted to investigate the prevalence of Pulmonary Arterial Hypertension (PAH) among chronic hemodialysis patients in sub-Saharan Africa, where its impact remains largely unknown.
- The study included 85 patients, finding a prevalence of PAH at 29.4%, with associated factors such as unsecured healthcare funding and cardiovascular complications like arrhythmia and diastolic dysfunction.
- The results suggest that about one third of hemodialysis patients suffer from PAH, highlighting a connection between this condition and socioeconomic challenges as well as cardiovascular health issues.
Background: The number of patients on dialysis has significantly increased worldwide. However, prospective studies estimating the cost of hemodialysis (HD) in sub-Saharan Africa remain scarce. The present study aimed to evaluate the direct cost of treating end stage renal disease.
View Article and Find Full Text PDFContext And Objective: In the estimation of glomerular filtration rate (GFR), ethnicity is an important determinant. However, all existing equations have been built solely from Caucasian and Afro-American populations and they are potentially inaccurate for estimating GFR in African populations. We therefore evaluated the performance of different estimated GFR (eGFR) equations in predicting measured GFR (mGFR).
View Article and Find Full Text PDFBackground: Stroke is the third leading cause of cardiovascular mortality in dialysis patients. The objective of this study was to assess the extent of stroke in chronic hemodialysis patients.
Methods: Historical cohort of patients enrolled in two hemodialysis (HD) centers from January 1, 2010 to December 31, 2011, including 191 patients (mean age 52 years, 68% men).
Background: Oxidative stress is thought to be involved in the pathogenesis of microalbuminuria in Sickle cell anemia (SCA). Antioxidant enzymes such as glutathione peroxidase (GPx) and Cu-Zn superoxide dismutase (SOD) may play an important protective role. This study aimed to evaluate the association between albuminuria and these two antioxidant enzymes.
View Article and Find Full Text PDFAcute kidney injury is a powerful independent predictor of mortality in critically ill patients: a multicenter prospective cohort study from Kinshasa, the Democratic Republic of Congo.
BMC Nephrol
August 2016
Background: Despite the growing incidence of acute kidney injury (AKI) worldwide, there is little data on the burden and outcomes of AKI in intensive care unit (ICU) in low resource settings. The present study assessed the incidence of AKI and its impact on mortality in ICU in Kinshasa (Democratic Republic of Congo).
Methods: In a prospective cohort study, 476 consecutive critically ill patients (mean age 52 years, 57 % male) were screened for the presence of AKI in seven ICU from January 1st to March 30th, 2015.