Publications by authors named "Yannick Avila"
Background: Knowledge about lung development or lung disease is mainly derived from data extrapolated from mouse models. This has obvious drawbacks in developmental diseases, particularly due to species differences. Our objective is to describe the development of complementary analysis methods that will allow a better understanding of the molecular mechanisms involved in the pathogenesis of rare congenital diseases.
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- Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally and may be triggered by both genetic and environmental factors, particularly early life nicotine exposure, which this study examines in relation to lung health and emphysema in adulthood.
- A two-hit model was used: mouse pups were exposed to nicotine in utero and during lactation, followed by elastase treatment at 11 weeks, with researchers measuring lung function and analyzing molecular changes over time.
- The study found that nicotine exposure did not adversely affect lung function compared to controls, but elastase treatment caused significant lung damage, inflammation, and alterations in lung mechanics, indicating the complex interplay between early life exposures and adult lung health.
Polyclonal rabbit anti-thymocyte globulin (rATG) is widely used in solid organ transplantation (SOT) as induction therapy or to treat corticosteroid-resistant rejection. In vivo, the effect of rATG on natural killer (NK) cells has not been studied. These cells are of particular relevance after SOT because classical immunosuppressive drugs do not inhibit or even can activate NK cells.
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