Genome-wide screen and multi-omics analysis reveal participate in the biosynthesis of safflower flavonoid glycosides.

Safflower, an economic crop, is renowned for its flowers, which are widely used in medicines for treating cardiovascular and cerebrovascular diseases and in dyes for food and industry. The utility of safflower depends on its flavonoid glycosides. Therefore, the biosynthesis of safflower flavonoid glycosides has been a focus of attention, but the present mechanisms remain poorly understood.

Cytogenetic abnormalities in -mutated acute myeloid leukemia.

acute myeloid leukemia (AML) has been identified as a distinct entity of myeloid neoplasms according to the 2017 European LeukemiaNet (ELN) guidelines. It confers a favorable prognosis regardless of cytogenetic abnormalities. We evaluated 418 newly diagnosed AML patients to test the validity of this hypothesis.

Glutamine synthetase facilitates cancer cells to recover from irradiation-induced G2/M arrest.

Resistance to radiation of cancer cells can be either intrinsic or acquired, leading to treatment failure. In response to DNA damage caused by IR, cancer cells are arrested in cell cycle showing limited proliferation and increased apoptosis. However, radiation-resistant cells are able to overcome the cell cycle block and proceed to proliferation, for which the detailed mechanism remains to be elucidated.

Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair.

Radiation resistance is a critical problem in radiotherapy for cancer. Radiation kills tumor cells mainly through causing DNA damage. Thus, efficiency of DNA damage repair is one of the most important factors that limits radiotherapy efficacy.

Adsorption of Cd(II), Cu(II) and Ni(II) ions by cross-linking chitosan/rectorite nano-hybrid composite microspheres.

Chitosan/rectorie (CTS/REC) nano-hybrid composite microsphere was prepared by changing the proportion of CTS/REC with 2:1, 3:1 and 4:1. Compared with the pure cross-linking chitosan microsphere, the nano-hybrid composite microsphere was proved to have better sorption capacity of Cd(II), Cu(II) and Ni(II), especially 2:1(CTS/REC-1). The adsorption behavior of the microsphere of Cd(II), Cu(II) and Ni(II) was investigated in single and binary metal systems.

Chitosan/organic rectorite composite for the magnetic uptake of methylene blue and methyl orange.

In this study, magnetic particles were prepared using organic rectorite as a carrier, and then a novel magnetic adsorbent named chitosan/organic rectorite-Fe3O4 intercalated composite microspheres (CS/Mt-OREC microspheres) was synthesized. The microspheres were characterized by XRD, FT-IR, TEM, SEM and VSM. The effects of adsorbent dosage, initial pH, contact time, temperatures, initial concentrations of methylene blue (MB) and methyl orange (MO) were studied.