Publications by authors named "Yanni Lu"
[Analysis of fat content and fatty acid composition of aquaculture products in Hainan Province].
Wei Sheng Yan Jiu
November 2023
Objective: To investigate the composition of fat and fatty acid in 12 kinds of aquaculture products in Hainan Province.
Methods: A total of 12 aquatic products were monitored in 8 breeding bases in Hainan Province, the edible parts were tested for fat and fatty acid. The content and composition of fat and fatty acid were analyzed.
Efficacy of Heshouwu () on gut mircobiota in mice with autoimmune encephalomyelitis.
J Tradit Chin Med
August 2023
Article Synopsis
- - The study aimed to explore the effects of Heshouwu, a Traditional Chinese Medicine (TCM), on neuroprotection and gut microbiota changes in a mouse model of multiple sclerosis (EAE).
- - Mice treated with different doses of Heshouwu showed reduced disease severity, improved neuro-pathology, and changes in gut microbiota diversity, alongside altered levels of specific immune cells and cytokines.
- - The results indicate that Heshouwu may benefit the immune response by modulating T cell dynamics and enhancing gut microbiota balance, suggesting its potential role in treating autoimmunity-related disorders.
Background: Thyroid cancer (TC), was the fastest-rising tumor of all malignancies in the world and China, predominantly differentiated thyroid cancer (DTC). However, evidence on TC stage distribution and influencing factors of late-stage were limited in China.
Methods: We carried out a retrospective study and enrolled TC patients who were first diagnosed and hospitalized in 8 hospitals in China in 2017.
Background: Lung cancer is the most common neoplasmas with a poor prognosis and a low 5-year survival rate. Early screening is an important measure for the prevention and treatment of lung cancer. At present, different countries have issued corresponding lung cancer screening guidelines, but China still lacks guidelines based on Chinese population research.
View Article and Find Full Text PDFBackground: Yunnan is a country with a high incidence of lung cancer in China and all over the world, and its morbidity and mortality are still rising. With changes in lifestyle and environment, the clinical epidemiological characteristics of lung cancer are converting. However, the trend of clinical characteristics of lung cancer in Yunnan has not been reported in the past 10 years, and we should start further research.
View Article and Find Full Text PDFThe study was designed to explore the drug-drug interactions mechanisms mediated by OATP1B1 between traditional Chinese medicine Danshensu and rosuvastatin. First, the changes of rosuvastatin pharmacokinetics were investigated in presence of Danshensu in rats. Then, the primary rat hepatocytes model was established to explore the effects of Danshensu on the uptake of rosuvastatin by hepatocytes.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to determine if ursolic acid can inhibit the transport of rosuvastatin by the breast cancer resistance protein (BCRP) in both living organisms and cell cultures.
- Results indicated that ursolic acid significantly influenced the pharmacokinetics of 5-fluorouracil and rosuvastatin in rats, and both ursolic acid and Ko143 effectively inhibited the BCRP-mediated transport of rosuvastatin.
- The findings suggest that ursolic acid may be a strong modulator of BCRP, impacting how rosuvastatin is processed in the body and its transport at the cellular level.
Specific binding and inhibition of 6-benzylaminopurine to catalase: multiple spectroscopic methods combined with molecular docking study.
Spectrochim Acta A Mol Biomol Spectrosc
April 2014
Article Synopsis
- 6-Benzylaminopurine (6-BA) is a plant hormone that affects antioxidant defense and was studied for its effects on beef liver catalase, an enzyme that helps break down hydrogen peroxide.
- The investigation utilized various methods including spectroscopy and molecular modeling, revealing that 6-BA binds to catalase, forming a complex that alters the enzyme's environment and affects its function.
- Results indicated that 6-BA inhibits catalase in a noncompetitive manner, with specific interactions and changes in enzyme structure identified through different spectroscopic techniques and docking studies.